curated by the members of the MSauerLab at Wuerzburg
Würzburg
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🚀 We’re moving to Bluesky! 🌟 From now on, you’ll find all our updates, insights, and discoveries there. We’re no longer posting on X.
🔗 Find us here: bsky.app/profile/sauer-lab.b…
📷 Or scan the QR code in the picture!
Let’s stay connected! 💡
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NEW📰🚨:"Protein-based PicoRulers set new standards for the verification of sub-10 nm super-resolution microscopy methods under cellular conditions."
▶️onlinelibrary.wiley.com/doi/…
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📢New Paper: "Expansion microscopy enables 4-color fluorescence imaging of synaptic protein organization with 20 nm spatial resolution."
➡️Here´s the link: doi.org/10.1117/1.NPh.10.4.0…
#FluorescenceFriday
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🚨New preprint: “Two-dye imager (TDI)-DNA-PAINT allows up to 15-fold faster imaging at higher resolution and whole cell imaging in 4 hours.”
▶️Link: biorxiv.org/content/10.1101/…
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Interested in how primary CD4+ and CD8+ CAR-T cells interact with tumor cells?
Check out our new manuscript: "CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites"❗️
Link:▶️biorxiv.org/content/10.1101/…
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➡️The secret of the 10 nm resolution barrier is revealed. Read all details how to bypass this barrier successfully in go.nature.com/3BBXIAz!
Ever wonder why nm localization precisions often don't translate to similar resolution below 10 nm? A paper from @LabSauer points to RET between fluorophores as a major factor. go.nature.com/3BBXIAz and see the accompanying N&V from @LMoeckl go.nature.com/3oMzwE4
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We are happy to share a new intriguingly easy way to perform high quality and fast DNA-PAINT using photoconversion of cyanine dyes. 🔬
Great collaboration with @SchnermannLab and Greer lab!
➡️PDF: chemrxiv.org/s/427482276392e…
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Have you ever dreamed of expanding membranes and visualize bacteria in infected cells with super-resolution? 🦠🔬
Here it is: Sphingolipid Expansion Microscopy❗️
(nature.com/articles/s41467-0…)
Great cooperation with the RudelLab and SeibelLab at @Uni_WUE !
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Synergy Grant ULTRARESOLUTION 🍾🔬
Thanks to @ERC_Research and my colleagues Silvio Rizzoli @uniGoettingen and Edward S. Boyden(@eboyden3) @MIT
Looking forward to see the brain at molecular resolution!
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Expansion-dSTORM realized: post-expansion labeling reduces the immunolabeling linkage error to ~ 5 nm and increases the labeling efficiency thus paving the way for true molecular resolution imaging 🔬 doi.org/10.1038/s41467-020-1…
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Happy to share our latest results on 3D multicolor super-resolution imaging of multiprotein complexes with 20-30 nm spatial resolution made possible by post-expansion labeling and SIM!🔬
nature.com/articles/s41467-0…
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Expansion microscopy enables visualization of synaptonemal complexes (1), bacterial infections (2) and dSTORM with molecular resolution (3)!🔬
All 3⃣ approaches are now available on bioRxiv!
❗️👉Find all links to the full-texts in the comments.
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Our 3D lattice light-sheet dSTORM paper is out today!🔬
"Whole-cell imaging of plasma membrane receptors by 3D-LLS-dSTORM!" nature.com/articles/s41467-0…
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Happy to host the Nikon Road Show @NikonInst 2019! 🔬 Visit us on 8th October to see the new confocal A1R HD25 in action (microscope.healthcare.nikon.…)
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We developed a tool (line-profiler.readthedocs.io…), to efficiently evaluate fibre like structures as #Microtubule and Synaptonemal Complex #SNC data. An easy to operate user interface is available on Zenodo. @Fabian_Zwettler @SebastianReinh6 #SuperResolution #Microscopy #dSTORM #SIM
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Check out our new manuscript: universal manual for super-resolution microscopy with tetrazine-dyes nature.com/articles/s42003-0…
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Check out our new manuscript! Super-resolution dSTORM of CD19/CD20 expression on primary tumor cells! nature.com/articles/s41467-0…
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