Professor, Salk Institute for Biological Studies
La Jolla, CA
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These two papers are a great example of coordination across labs. It was amazing to work alongside @LabJorgeCasal @BeluBorniego and @Ezequie50862853.
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Together, our two papers converge on a unified model:
Temperature simultaneously:
1- increases ARF abundance
2- increases ARF solubility
3- shifts ARF subcellular localization
All driving higher nuclear, active ARF pools.
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In back-to-back papers, our lab and the Casal lab tackle the question: How does temperature reshape auxin-driven growth?
Together, we reveal that temperature directly rewires ARF behavior.
nature.com/articles/s41467-0…
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The lab is moving from Duke to the Salk Institute! We are thrilled to join an inspiring community where we will continue to explore plant growth and development.
Deep gratitude for the years of support and collaboration at Duke/NCSU/UNC.
Big news! World-renowned plant biologist Lucia Strader, previously at Duke University, will join the Salk faculty this October. 🌿
Strader’s work will advance our understanding of plant growth signaling and help Salk’s Harnessing Plants Initiative design more resilient crops that can thrive in changing environments. 🌽
Professor Strader will be supported by the Howard H. and Maryam R. Newman Chair in Plant Biology, previously held by the late Professor Joanne Chory.
“Salk has something that can’t be found in other places,” says Strader. “The Institute has a uniquely focused mission that allows its faculty to move science forward with fewer distractions. I’m excited to work with colleagues who share a genuine interest and dedication to pushing the boundaries of knowledge and making a real-world impact.”
Join us in welcoming Professor Lucia Strader! Read more: salk.edu/news-release/plant-…
#SalkScience #HarnessingPlantsInitiative #PlantScience #PlantBiology #SustainableAgriculture #WelcomeToSalk
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Big implications:
Explains size and shape of cytoplasmic condensates
May underlie condensate aging, mechanical sensing, and compartmentalization
Opens door to targeting motility to regulate phase separation—e.g., in viral replication or synthetic biology
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Biomolecular condensates organize cellular contents.
Most studies focus on passive phase separation, driven by salt, pH, or temperature.
But what if intracellular movement also matters?
science.org/doi/10.1126/scia…
Here, we explore motility-induced condensation in a cellular context.
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Cool new multi-target CRISPR strategy for overcoming genetic redundancy from Yuqin Zhang and Eilon Shani.
nature.com/articles/s41467-0…
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Suresh deserves all the credit for this - his keen observational skills really opened this new line of inquiry. A rare two-author publication!
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What regulates plant de novo organogenesis? Led by postdoc Suresh Damodaran, we discover that not all hypocotyl cells are equally competent to create a new root meristem after excision of the primary root.
authors.elsevier.com/a/1jTSe…
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And valuable help from @RClayWright to help examine ARF7 ADs in yeast. This work took a village.
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Our approach provides a roadmap for other groups studying IDR features and their relationship to function. We believe this comprehensive methodology will have a far-reaching impact on the characterization of IDRs, enabling significant advancements in this field.
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We developed an analytical framework for unsupervised learning with coarse-grained sequence features, rather than linear sequence, to predict activities of intrinsically disordered regions (IDRs), which presents a major advance in how we correlate sequence features to function.
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Our data has allowed for deeper insight into sequence features that are required for recruitment of the transcriptional machinery and our unsupervised subtyping of ADs uncovers new future areas of exploration.
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We provide a community resource that allows for Arabidopsis researchers to determine whether their TF of interest carries an activation domain. Data for each TF is provided in manuscript and also viewable on the AGRIS TF database (agris-knowledgebase.org/AtTF…).
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We expanded our study to identify ADs within the ancient AUXIN RESPONSE FACTOR (ARF) family of TFs, uncovering conservation of AD positioning, but not sequence, in distinct clades. This conservation is invisible in traditional sequence alignments.
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