Plasmid-mediated antibiotic resistance. Microbiologist and bioinformatician 🧬🖥️
Community of Madrid, Spain
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📢 New preprint!! Combining transcriptomics, genetic engineering and CRISPRi silencing, we unveiled a plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria - 1/10 🧵👇
biorxiv.org/content/10.1101/…
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🔔 Check out our new opinion article published at @TrendsMicrobiol!!
cell.com/trends/microbiology…
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What a way to end the year, with our latest paper finally out in @NatureComms!! 🎉🍾
nature.com/articles/s41467-0…
📢 New preprint!! Combining transcriptomics, genetic engineering and CRISPRi silencing, we unveiled a plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria - 1/10 🧵👇
biorxiv.org/content/10.1101/…
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Laura Toribio-Celestino retweeted
Finally out after peer review. The first SuperIntegron-less Vibrio cholerae... and it is virtually identical to the WT! doi.org/10.1093/nar/gkae866
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Laura Toribio-Celestino retweeted
How do plasmids interact with their bacterial hosts? 🧬🦠
New research from @AlvSanMillan & @LauraToribioC uncovers fascinating crosstalk between plasmids and chromosomes. Really cool!💡
biorxiv.org/content/10.1101/…
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📢 New preprint!! Combining transcriptomics, genetic engineering and CRISPRi silencing, we unveiled a plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria - 1/10 🧵👇
biorxiv.org/content/10.1101/…
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Finally, by expressing the pOXA-48-encoded lysR in trans and by silencing the pfp-ifp operon using CRISPRi technology, we demonstrated that the overexpression of the pfp-ifp operon is beneficial for pOXA-48-carrying Klebsiella pneumoniae - 9/10 (10/10 👇)
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Laura Toribio-Celestino retweeted
Another great retreat at my grandfather's farm! This year with @asanchez_lab @AlvSanMillan @Jero_RB @TMcoque @jaegc and @aneperezcobas labs. What a lineup! La Cerca '24.
A scientific meeting in my grandfather's farm. I cannot be happier and prouder. La cerca '22.
Thanks to @AlvSanMillan @jaegc et al.
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Laura Toribio-Celestino retweeted
And its out!
New paper for #integron aficionados. We found gene-less cassettes in superintegrons that express/silence other cassettes in the array.
Here is a 🧵
Identification of promoter activity in gene-less cassettes from Vibrionaceae superintegrons academic.oup.com/nar/advance…
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Laura Toribio-Celestino retweeted
🚨 Preprint alert 🚨
The first work from my lab where we expose the Achilles’ heel of beta-lactamase-producing enterobacteria is now out!!
Great effort led by @Cris_Herencias & @Lauralvllo in close collaboration with my friend @AlvSanMillan!!
Check the details below!! 👇
Our new preprint on collateral sensitivity in E. coli is now available! We combined classic experimental approaches with high-throughput analyses of AMR surveillance databases to unravel new CS responses to one of the most relevant mobile AMR mechanisms: β-lactamases🧵👇
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Laura Toribio-Celestino retweeted
Our new preprint on collateral sensitivity in E. coli is now available! We combined classic experimental approaches with high-throughput analyses of AMR surveillance databases to unravel new CS responses to one of the most relevant mobile AMR mechanisms: β-lactamases🧵👇
β-lactamase expression induces collateral sensitivity in Escherichia coli biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Laura Toribio-Celestino retweeted
Check out our last work with @CelineLoot, @amazeld, @AlvSanMillan and @SkovgaardOle We have deleted the Superintegron from V. cholerae! A long-awaited feat in the field!! Despite losing 3% of the genome, the strain remains identical!! 😵 biorxiv.org/content/10.1101/…
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