Curious about the latest brain breakthroughs in tech and biotech? Check out Longevity Global's Brain Optimization Summit during SF #TechWeek. Sunday Oct 11 10a- 5p MBC BioLabs 135 Mississippi St, SF Register: longevitygl.org/brain-optimi…

Looking forward to the #Younger contest webinar on gut microbiome with guest Speaker Dr. Momo Vuyisich, PhD Co-founder & Chief Science Officer of @MyViome. luma.com/3p3rb8vh

Are longevity drugs hiding in plain sight? A new study by Insilico Medicine illustrates what adding aging clocks to clinical trials could reveal Most drug trials draw blood at several visits and measure whether a treatment helped one disease. Very few check whether the drug also changed how fast people are aging. Adding aging clocks to trials that are already happening could reveal drugs that slow aging across many diseases. Two recent studies show what that could look like. 💉 Semaglutide slowed epigenetic aging in a randomized trial of people with HIV. The treated group measured about 4.9 years younger on PhenoAge, with a pace of aging about 9% slower on DunedinPACE. Aging was never an outcome in the original trial. 🫁 Rentosertib, an AI-designed lung fibrosis drug from Insilico Medicine, lowered predicted biological age on six independent proteomic clocks, by roughly three to four years at week 4. 🧬 Its target, TNIK, was picked partly for its links to aging. In cell studies, blocking it reduced senescence through TGF-β signaling. 🧪 Both analyses used stored blood from trials that had already ended. There is nuance the headlines miss. Rentosertib was tested only in people with lung fibrosis, so part of the clock drop could reflect a lung that is healing. Giving it to healthy people would answer that question. The clock signal also leveled off after week 4, and the reason is still unknown. I think stored samples from completed trials are one of the faster routes to finding candidate longevity drugs. The next longevity drug may come out of a kidney or liver trial where nobody thought to run a clock. Link to full post: drglorioso.substack.com/p/ar…

We are excited for Longevity Global's 2nd annual Brain Optimization Summit during SF TECH WEEK by a16z. Sun Oct. 11 10 a- 5pm RSVP: partiful.com/e/PILcXc8bpt6Aw… We have some great speakers: @RonjonNag, Blake Gurfein, Brian Tsui, @Natalise Kalea Robinson, Mike Olson, @alcaide_ramses, Laura Hix Glickman, PhD, @PaolaTelfer, Antonio Forenza, PhD, John Forrest, Salah Mahmoudi, Tom Zuber.

Why You Should Be Skeptical of Health Skeptics Wellness influencers are selling you miracles. But professional health skeptics could be selling you something, too. I particularly enjoyed this Substack from Time Magazine writer, Matt Fuchs. I have found that people tend to share/interact with the few "debunking posts" I have made more than a balanced take on the murky state of science of a topic. And this gain from debunking resonates a lot RE:aging clocks "In a lecture transcript I recently saw, a scientist poked fun at media outlets for covering research in ways that suggest regular coffee-drinking bestows longevity. He pointed to the proclaimed links between three cups of coffee per day and longer life, expressing sincere doubt that his one cup that morning would make him live longer. The gist was that there’s no truth to any of this. But there’s some truth to it. Large observational studies consistently find that drinking coffee is associated with better odds of enjoying a longer life. Associations don’t prove causation, but it’s also true that absence of evidence isn’t evidence of absence. This post isn’t about coffee. It’s about the hype / hyper-skepticism cycle that takes up too much real estate in the health journalism landscape... We tend to mistake skepticism for neutrality because it sounds like restraint and rigor. But there’s reason for caution on both sides of the hype / anti-hype cycle. Skeptics can cherry-pick and overstate certainty just as much as the people making the original health claim... But these trends also create a market for debunking. A growing segment of doctors, researchers and science communicators are now devoted to dispelling health claims. Just like anyone else in the media ecosystem, skeptics have careers, public platforms and egos. Even if they’re not hawking pills, detox foot pads or grounding sheets, they have something to sell you: their brand of skepticism. Such skeptics may be just as invested as their wellness-hyping counterparts." Full Substack: fuchsm.substack.com/p/why-yo…

RT @DrGlorioso: On November 7 I will be at The Armory in NYC with about 960 other people competing in the first Super Age Games. 8 trials,…

RT @DrGlorioso: 🥇 Excited to announce we were awarded a $500k SBIR grant today for our Alzheimer's therapeutic program. 🎉 Most people pro…

This Thursday (Sep 17) I dive into the controversial world of longevity diets via free webinar! Come wade into the keto, protein, and fat wars. See why I have chosen the diet I have to win the Younger Biological Age Contest. RSVP: luma.com/zufyhb37

Free Yoga Sculpt class in SF Oct 21st as part of the #Younger biological age contest programming. Anyone is welcome. Yoga Sculpt is one of my favorite workouts for turning back the aging clocks. It's a hot yoga class (95 degrees) with weights and a cardio burst in the middle. It counts for balance, flexibility, resistance training, HIIT, sauna, community, and meditation, checking multiple boxes at once for your training. Tomi will be teaching who is one of my favorite instructors. RSVP: luma.com/b2iekbrk

Curious about the latest brain breakthroughs in tech and biotech? Check out Longevity Global's Brain Optimization Summit during SF #TechWeek. Sunday Oct 11 10a- 5p MBC BioLabs 135 Mississippi St, SF Register: longevitygl.org/brain-optimi…

Two New Studies Point to Positive Benefits of HRT for Dementia Prevention Does hormone therapy protect the brain? This has been hotly debated over the last 20 years. Two large studies published this August point in the positive direction, adding to our knowledge but not settling the question. 🧠 Stanford looked at autopsied brains. Women who used estrogen-only therapy had 35% lower odds of the amyloid plaques and tau tangles that define Alzheimer's. 📊 UK Biobank followed 183,450 women for 13 years. Hormone therapy was linked to 10% lower dementia risk overall and 26% lower after surgical menopause. APOE4 carriers saw a 13% reduction. ⏱️ The benefit was concentrated in women who started between 46 and 56. 🔬 These are observational studies, and the randomized trial with modern hormones has not been done. The harm seen with late starts came from older formulations in older women. My Take I take hormone therapy for several reasons, idementia prevention and my APOE4 allele amongst them. It also resolved a sleep problem that had not responded to anything else, lifted my mood, and gave me the energy to exercise consistently, and each of those supports the brain on its own. HRT is not for everyone, breast cancer or clotting history changes the calculus. If you are contemplating start HRT, make sure you have a physician who is familiar with the 2026 data and not just spouting headlines from 20 years ago. Full article: drglorioso.substack.com/p/tw…

One of the best longevity tests is time for 5X sit-to-stand. Here I show how to do it. This is one of my best baseline results in the Younger contest- my time is average for an 18 yo. Sit-to-stand benefits: ⏱️ Faster five-times sit-to-stand times in middle and older age are associated with roughly half the all-cause mortality over the following decade compared with the slowest performers, in pooled data from several cohorts. 🧑‍🦼 Completing the five repetitions in under about 15 seconds is associated with a substantially lower risk of falls and of developing mobility disability in older adults. 🧠 Faster times also predict a lower risk of frailty, hospitalization, cognitive decline, and incident dementia over the following 5 to 10 years, independent of age and education. 🧠 The test measures leg power, balance, and executive function together, since standing repeatedly requires motor planning as well as strength, which is why good performance reflects brain health better than grip strength alone. 🧠 Better leg power is associated with more preserved gray matter and hippocampal volume and fewer white matter lesions on MRI, and in a 10-year twin study it was one of the strongest predictors of healthy cognitive aging even after accounting for shared genetics. 📈 Resistance and power training can shorten sit-to-stand time within 8 to 12 weeks, and randomized trials show this kind of training improves executive function and reduces fall risk. Best training exercises: -box jumps -squat jumps -leg press -hamstring curl

RT @DrGlorioso: A habit I'm instilling for the #Younger Biological Aging Competition- 4 glasses of green tea/day. I brew the tea in batch…

Free Yoga Sculpt Class for #Younger Training from our Community partner, CorePower Yoga Oct 21 , 5:45pm in San Francisco. This was me this morning with one of my favorite instructors who will also be teaching the class, Tomi. RSVP: luma.com/b2iekbrk

RT @DrGlorioso: Ozempic extends lifespan in mice according to a new paper in Nature out of Danica Chen's lab at Berkeley. 🐭 They treated o…

Today in #Younger Contest training Jogged to Mountain Lake park. 11k steps, zone 2 and 3 (base for VO2 max). There was a "parcourse" there, which had stations relevant for the Super Age games I'm competing in in November. I was wondering where I would find "crawling across a net" practice. Turns out about a mile from my house. Unfortunately it was a little rainy for the pull up bar and the balance beam but I'll definitely be back for all the stations. @RonjonNag in case you want to practice

The #Younger Biological Aging Competition is excited to have @Vero_Bioscience as an official testing partner for the Ultra Tier. Vero is a proteomics organ-age company spun out from the lab of and co-founded by Stanford Professor, @wysscoray. You may have seen their organ ages on the cover of Nature. Their proteomics clock is not yet on the market so its a special opportunity to have this cutting edge diagnostic ahead of commercial availability. We are also excited to have Vero's CEO, Paul Coletta, competing in Younger. I'm looking forward to seeing his protocol and what he recommends for winning. Learn more about Younger: neuroagetx.com/events/younge…

I spoke with Ronjon Nag on the R42 Group podcast! Thanks to Steve Sprich and Ally Koh for helping make this a reality. Here's what we discussed: • What “brain age” actually means and how it can be measured • Alzheimer’s risk and the importance of earlier detection • Exercise, diet, sleep and cognitive activity for brain health • The Younger Competition and what may change over six months • Personalized approaches to longevity and healthy aging • Peptides, supplements and the limits of current evidence • Creatine, nootropics and potential cognitive benefits • Where the science of brain aging may be headed next Take a listen on Spotify: open.spotify.com/episode/26Y…

The duckweed smoothie behind the best longevity diet, green mediterranean (new study) I will be eating Green Mediterranean to try and win the Younger Biological Age Contest and will be recommending it to contest participants. That’s because it has the most evidence for health benefits and moving aging clocks according to a new paper in Nature Medicine co-authored by Raghav Sehgal, PhD. A center piece of that diet is Mankai, a little green floating plant also known as duckweed. Duckweed facts: -It has been eaten for generations in parts of Southeast Asia, where it is sometimes called a vegetable meatball because it has an exceptionally high protein content and a complete amino acid profile. -one serving has 25% of your daily omega-3 -A duckweed /green med diet RCT showed it reduced waist size, reduced fatty liver, cut age-related decline in brain volume by 50% and this was vs. regular med diet, which already does these things. -green med turned the most clocks back in the new Nature Med paper Full post and duckweed smoothie recipe: drglorioso.substack.com/p/th… The recipe is also part of the Younger Cookbook that participants will be receiving.

Today at the Younger Competition longevity group exercise class! Thanks to Ian White for instructing us.