ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/BindCra…

If you work with node trees in #b3d - I've saved you a lot of frustration. My talk for BCON2026 about my `nobdepy` python package has been posted to YT. Python code <--> Node trees Fixes collaboration and versioning of node assets #GeometryNodes

I’m a scientist. I need to say this because the AI hype is getting ridiculous. AI can design a molecule in seconds. That doesn’t mean it discovered a drug. It discovered something we scientists have never been short of: Something to test. Someone still has to make it. Run the experiment. Measure whether it works. Check whether it’s toxic. And ultimately prove it works in the real world. AI hype tells us: “Prediction is discovery.” “Simulation is experimentation.” “Generating a molecule is developing a drug.” It isn’t. AI is making ideas incredibly cheap. But every new idea creates something AI cannot generate: Evidence. And the more hypotheses AI produces, the more experiments we’re going to need. That’s the irony nobody seems to be talking about. AI may not make laboratories obsolete. It may make them more valuable than ever. You can speedrun the thinking. You can’t speedrun reality.

I was honestly hoping for BindCraft: FoldWar, before a fully fledged BindCraft2.

Design cheaper binders with BindCraft2 ❤️

BindCraft 2 reports ~22x lower GPU time per 100 passing designs. I was curious where that speedup actually comes from so I gave both repos to Astra. The result was NOT what I expected 🤯 JK, it kind of was. Here is what changed:

I found my new favourite painting

Bindcraft2 🤝 Claude 🤝 Adaptyv apply for our protein design competition and solve all the challenges docs.google.com/forms/d/e/1F…

It's amazing to see BindCraft2 out and I'm even more excited to see what the community can do with it! We've found that Claude excels most when provided with a complex search space to navigate. BindCraft2 expands the search space of molecule design by enabling more modalities and targets, and it's faster. See what you and Claude can do with BindCraft2 in our competition co-sponsored with @adaptyvbio! Sign up here: docs.google.com/forms/d/e/1F… Learn more here: proteinbase.com/competitions…

Sign-up to the Anthropic x Adaptyv protein design competition here: proteinbase.com/competitions…

Huge congrats to @MartinPacesa and team for the first big release from his lab. BindCraft2 is absolutely 🔥. The speedups are amazing and there are so many added features. Plus it's completely free for academic and commercial use. 🐐

Very excited for BindCraft 2! It's incredible to me that it feels like binder design took off like crazy over the past 18 mo, but BindCraft came out Oct 2024, and it's somehow still competitive with the best (see the Ant paper). Also a testament to the strength of AF2!

Target cross reactivity in the Adaptyv competition is a perfect use case for BindCraft2 natively. Try it out here: Overview + modalities: pacesalab.com/bindcraft Code: github.com/PacesaLab/BindCra… BindCraft1 variant by Lennart Nickel and Paul Kittner github.com/martinpacesa/Bind…

And ʙɪɴᴅᴄʀᴀꜰᴛ2 is for everyone: we've teamed up with @adaptyvbio, @AriaxBio & @tamarindbio to host it, so anyone can run it without a GPU. Built by Erik Mäeots, @eliza_chernova , Leonardo Tredese & Jan Dernic. Special thanks to @sokrypton & Lennart Nickel. 🚀

Design modalities galore!

BindCraft2 is out, ready to use on Tamarind on day one. The workflow expands on the original BindCraft substantially. Most notably, now supporting VHH, scFv, Fab, and seven other binder modalities, supporting multi-state targets, and multiple targets at once.

Back in 2024, BindCraft1 emerged as one of the strongest methods in our protein design benchmarks, winning our first EGFR competition and becoming one of the most widely used approaches in the following round. We’re happy to see BindCraft2 released just in time for our new protein design competition with Anthropic, where more than 5,000 designs will be experimentally tested in our lab. Show us what you can do with BindCraft2!

Seeing the BC2 "leak" performing so well in the RBX1 competition felt a lot like seeing the recent Opus 5.5 leaks. Congrats to @MartinPacesa and the team for pretty much defining the current paradigm in de novo binder design!

BindCraft2 from the @MartinPacesa lab is here and available now on Ariax! We called BindCraft a “DeepSeek moment” in protein design. BC2 builds on that proven foundation with major speed improvements and a much broader range of therapeutic formats. ariax.bio/resources/bindcraf…