Before you diagnose CIDP:
✅ Make sure to check if the motor conduction velocity is truly in the demyelinating range. Upper limb CV should be slower than 35 m/s and lower limb less than 25 m/s. Be careful with amplitude-dependent slowing.
✅ Consider whether it's a variant — if so, be aware that these cases are more prone to misdiagnosis.
✅ Exercise caution with elevated CSF protein levels, as this finding is non-specific and should not be solely relied upon for diagnosis.
✅ Look for the presence of monoclonal gammopathy, which could indicate POEMS syndrome, AL amyloid, or IgM/Anti-MAG neuropathy.
✅ If any of these are present consider an auto-immune nodopathy: markedly elevated CSF protein (>200 Mg/dl), distal predominant weakness, CNS demyelination, nephrotic syndrome, marked hypertrophy of nerve roots and plexi, respiratory failure, or cranial neuropathy
✅ Finally, verify your diagnosis against the EAN/PNS guidelines to ensure accuracy here:
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