Lynn Megeney@MegeneyLab

We study the fascinating non-lethal biology of caspase/metacaspase proteases ☠️. We are also interested in the molecular cues that manage cardiac remodeling🫀

 Ottawa Hospital Research Inst.
ohri.ca/profile/lmegeney/pro…
Joined March 2023
49 Photos and videos
Lynn Megeney retweeted
Terry Hébert@THebertMcGill
Sep 11
Eight years of work! So proud of the whole team! nature.com/articles/s44385-0…

Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients...

npj Biomedical Innovations - Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy

nature.com
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New @ScienceAdvances paper: Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy. #DMD tinyurl.com/36crszy6

Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin....

science.org
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Lynn Megeney retweeted
Peter MacKay@PeterMacKay
Jul 24
In his 90th yr our beloved father Elmer was called home. His was an extraordinary life, collecting legions of friends leaving a legacy of hard work & public service. He loved the forest, poetry, sport, law & good debate, the Yankees & especially his family. Deeply missed & alive in our hearts. Sleep well Pop, you earned your rest.
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Ben Weaver@WeaverScience
May 5
Just published!! Congrat's to my post-doc Wang for getting featured on the cover of Science Signaling. So proud!! So much more to learn about phenotypic plasticity. science.org/eprint/XZZZRR72V…

A Caenorhabditis elegans spatiotemporal proximity atlas reveals the MAPK p38 as a generator of...

Proximity labeling identifies factors that contribute to p38-driven phenotypic plasticity in C. elegans.

science.org
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Lynn Megeney retweeted
Ben Weaver@WeaverScience
May 14
Excited to share the news!! So proud of my postdoc Wang now promoted to Research Scientist!! Protein coordinates responses to environmental stress: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/…

Protein coordinates responses to environmental stress

UT Southwestern Medical Center researchers have discovered a key molecular mechanism that allows animals to adapt to changing environmental conditions without altering their genes – an ability known...

utsouthwestern.edu
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Dr Sharma is the 23rd graduate student to conquer the Megeney Lab training gauntlet!🤓🍺👍🏻
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Congratulations to Dr. Anupam Sharma (the latest Megeney lab grad) on the successful defence of his PhD, on July 7th!!!! Fantastic examining committee which included (left to right) Drs. Kim, McKinsey, Tuana, the newly minted Dr. Sharma, Dr. Stanford and myself. Well done!!!!
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Science News
@ScienceNews
Jan 6
Lung cancer patients who received an mRNA COVID-19 vaccine within a few months of immunotherapy lived nearly twice as long as unvaccinated patients. sciencenews.org/article/canc…

Cancer treatments may get a boost from mRNA COVID vaccines

Cancer patients who got an mRNA COVID vaccine within a few months of their immunotherapy lived longer than those who did not, health records show.

sciencenews.org
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Book signing with Dr Tony Sanfilippo, and his amazing wife Michelle. Tony is the author of “The doctors we need” ⁦@QueensuDOM⁩ ⁦@KingstonHSC⁩ ⁦@queensutime⁩ -a great read on how Canada can solve its doctor shortage problem-a must read!
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Interesting work from @Rudnicki_Lab in @NatureComms : Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis. tinyurl.com/4byakujj
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Lynn Megeney retweeted
David Picketts@DPicketts
10 Nov 2025
Excited to share our paper with Ghayda Mirzaa describing the novel SMARCA1-related NDD. Out today in Nature Communications. rdcu.be/ePaDp
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We’re proud to celebrate @CincyKidsHeart's Jeff Molkentin, PhD, for receiving @UCincyMedicine's 2025 Daniel Drake Medal—college's highest honor! His groundbreaking work in cardiovascular biology continues to advance science & inspire next-gen researchers: scienceblog.cincinnatichildr…

Molkentin Honored with 2025 Drake Medal - Research Horizons

Jeffery Molkentin, Heart Institute co-director, receives UC's highest honor recognizing his career of pioneering cardiovascular research.

scienceblog.cincinnatichildrens.org
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New @NatureComms paper: Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction. tinyurl.com/4knhr7mh

Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction

Nature Communications - The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive...

nature.com
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Lynn Megeney retweeted
Joe Gordon@josephwgordon
11 Nov 2025
embopress.org/doi/full/10.10…
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Celebrating an amazing trip up Mount Kilimanjaro with daughter Elizabeth, supported by team Ultimate Kilimanjaro ⁦@UltimateKili⁩ @QueensuDOM⁩ ⁦@queensutime⁩ ⁦@KingstonHSC⁩ -19341 feet of challenging, hypoxic beauty. One of the hardest things I’ve ever done!
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New @NatureComms paper: Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy. #DMD tinyurl.com/34nufjed

Large-scale serum protein biomarkers discovery associated with function and clinical milestones in...

Nature Communications - Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. In this study, the authors identified proteins in blood that correlate with disease progression,...

nature.com
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Congrats to @LorsonLab and colleagues for their new @hmg_journal paper: Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present early and chronic axonal neuropathy. tinyurl.com/y9x94c8z

Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present...

Abstract. Charcot–Marie-Tooth (CMT) is the most common hereditary peripheral neuropathy with an incidence of 1:2500. CMT2 clinical symptoms include distal

academic.oup.com
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one of the most interesting papers on muscle biology in decades....a challenge to the satellite cell hypothesis!!!! Muscle growth by sarcomere divisions | Science Advances science.org/doi/10.1126/scia…

Muscle growth by sarcomere divisions

When muscle cells enlarge during developmental growth, they divide their contractile sarcomeres into daughter sarcomeres.

science.org
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New @NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD tinyurl.com/bdhwrkka
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Interesting new #JACC paper: Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation. tinyurl.com/2t5rv79t

Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation:

jacc.org
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