Neuroscientist 🧠👩🏽💻 I use MRI to study multiple sclerosis, improve its diagnosis and predict the future course of the disease ✨
Nottingham, England
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I’m so happy to share the results from our small but very exciting 7T study - my first paper as a senior author! 🤓 🧠 We explore the prevalence and dynamics of T1 dark rims in new and established lesions, including PRLs, and propose the origin of the dark signal on T1 MRI👇🏼
T1‐Dark Rim as a Marker of New and Chronic Active Multiple Sclerosis Lesions: A Serial Study With Frequent 7T MRI
onlinelibrary.wiley.com/doi/…
#neuroimaging #neurology #neurorad #radres @WileyNeuro @asneuroimaging #multiplesclerosis #chronicactivelesions #7T #MRI
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Megi Clarke retweeted
Our MS Frontiers conference is the UK's largest biennial conference for MS research professionals. 🧡
Ahead of this year’s conference, we’re inviting researchers to submit their abstracts before the deadline of Wednesday 4 February.
Find out more: mssoc.uk/4sEOo72
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🔬 New Resource for MS Diagnosis: Central Vein Sign Website centralvein.com
We are excited to announce a new website dedicated to supporting neurologists, radiologists, and radiographers in the use of the CVS as a diagnostic marker in suspected multiple sclerosis
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👉 What the website offers:
• Guidance on how you can easily access SWI sequences on all major MRI scanners (GE, Philips, Siemens)
• Step‑by‑step recommendations to simplify implementation
• A central hub for clinicians who have been asking how to obtain these sequences
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10 years ago, I attended my 1st ECTRIMS in Barcelona presenting results on the central vein sign in MS! A decade later, the CVS is in the new MS diagnostic criteria and our team just presented results of a new proposed diagnostic marker: T1-dark rims! Love to see the progress!💪🏼
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Megi Clarke retweeted
1/ Very exciting work by @MegiClarke, M. Marshall, and team on the T1 dark rim on 7T! Congratulations!
onlinelibrary.wiley.com/doi/…
ALT images from: https://onlinelibrary.wiley.com/doi/full/10.1111/jon.70044
I’m so happy to share the results from our small but very exciting 7T study - my first paper as a senior author! 🤓 🧠 We explore the prevalence and dynamics of T1 dark rims in new and established lesions, including PRLs, and propose the origin of the dark signal on T1 MRI👇🏼
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Megi Clarke retweeted
An 8 minute MRI scan could replace painful spinal taps in diagnosing multiple sclerosis, a study led by @nikosevangelou3 @MedicineUoN @UoNFacultyMHS #MS #MultipleSclerosis
Read more @DailyMail ▶️ow.ly/H3Vp50VZV7R
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Megi Clarke retweeted
J Neuroimag: "T1-dark #rims were more common than QSM rims, w/ greater prev in newly formed #lesions. We propose they represent edema & inflammation assoc w/ early stages of chronic active lesion formation visible despite, not bcse of, #iron accumulation." doi.org/10.1111/jon.70044
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Can the central vein sign offer an alternative to lumbar punctures?#MS
Check out our latest results from a multi-centre, prospective study of 99 ppl presenting with typical CIS. We report not only sensitivity analyses but also discuss patient preferences.
neurology.org/doi/10.1212/WN…
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Megi Clarke retweeted
Incredible 7T MRI images in multiple sclerosis showing perivenular lesions with T1-dark rims on magnetization prepared 2 rapid gradient-echo onlinelibrary.wiley.com/doi/…
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Megi Clarke retweeted
The Spring 2025 issue of our Nottingham MS Research Group's newsletter is now available to read online. Discover more about some of our ongoing research studies in #MultipleSclerosis
🔗 neuroms.org/images/Newslette…
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Proud to be presenting at #ABN2025 in Liverpool. We show that the NAIMS CVS assessment criteria are needed to maintain diagnostic performance of a simplified CVS rule (finding 6 CVS+ lesions). Finding more CVS+ lesions further increased specificity while maintaining sensitivity.
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Exciting opportunity for a postdoc with skills in neuroimaging and MS! I spent a year with this fantastic team in ☀️ Barcelona a few years ago and it was one of the highlights of my career so far! 🧠
Postdoctoral Fellow (Neuroradiology) - VHIR jobs.vhir.org/jobs/internal/…
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Many thanks to @ECTRIMS for organising a fantastic workshop on the upcoming revisions to the McDonald diagnostic criteria for MS! It’s amazing to see how years of accumulating research evidence is now going to change clinical practice across the world!
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Megi Clarke retweeted
We want to improve how we diagnose people with MS! We're trying to avoid lumbar punctures. If you've been diagnosed with MS in the last 10 years, or know someone who has, get in touch! Let's improve care together! @BlancaDios @nikosevangelou3 @MegiClarke @chloechiengg
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Another great @ECTRIMS meeting is over! The highlight for me was seeing the CVS and PRLs added to the latest McDonald diagnostic criteria for MS - at last! See you all again next year in Barcelona! #ECTRIMS2024
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Paramagnetic rim lesions have now been incorporated into the revised McDonald criteria for MS. But there is even more we can see on susceptibility imaging! The appearance of PRLs is heterogeneous and might be related to their long-term evolution. Find out more P695 #ECTRIMS2024
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