With the rapidly growing interests in microbiome research, we are here to facilitate discussions and post-publication reviews. PM if you have a story to share.
One should also consider that many of the health benefits claimed by these prebiotics/probiotics products in the supermarkets have limited scientific evidence of support.
Review combining 26 papers on gut microbiota changes in children with autism spectrum disorder:
"These results were inadequate to confirm a global microbiome change in children with ASD and causality could not be inferred"
link.springer.com/article/10…
The risk of fecal transplantation needs better assessment!
Patient dies from fecal transplant containing drug-resistant bacteria. nbcnews.com/health/health-ne… via @nbcnews
What this study (goo.gl/kk9DDL ) found: Infants with higher BMI tended to be associated with more household disinfectant use, and the relative abundance of particular bacterial FAMILIES appeared different.
News: Disinfectants make your baby fat through the microbiome!
We are skeptical about exaggerated benefits of probiotics, but where in hell does this paper (goo.gl/qz8GLh) show probiotics are "useless and can actually hurt you"?!?!??! 1/3
"The outcome was striking...the microbes found in faeces were not representative of those that had colonised the gut".
This is known for a long time. Why is it striking that fecal microbiome is distinguishable from the gut when you know some microbes colonize some dont? 2/3.
Eep, watch out for this press release -- the microbiome hype factor is super high. And it concerns a vulnerable group. Not cool.
To set the record straight:
- This was a mouse study only
- No, preventing autism is clearly not as simple as altering diet...
newswise.com/articles/view/6…
A caveat with OTU that wasn't discussed much is the use of a uniform %identify threshold across all taxa (say, 97%). Variation shall be considered species-by-species.
Our research group still mainly uses on OTU's , but it does seem that many are moving to ASV's. Here's a nice article from nature that describes some of the pros and cons of OTU's vs ASV's. nature.com/articles/ismej201…
Instead of generalizing that "fibers are good for your microbiome". We need more meta-analyses and consider the genotype difference! academic.oup.com/ajcn/articl…