In all the discussion about colonising Mars, I don't see much about how the soil is poisonous to us. This was only discovered in 2008. It contains perchlorates, which are environmental toxins here on Earth. Any human contact with Mars dust? Bad news in the long run. 1/
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That's basically *the entire surface of the planet* being poisonous - not just to us, but plant life too. Even if the temperature, pressure, radiation and various other human biology problems are solved, this alone will be a super-hard thing to fix: sciencedirect.com/science/ar… 2/

Sep 22, 2026 · 9:46 PM UTC

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But as that paper says - not impossible! Organisms could be tweaked or engineered to convert (ie. eat) perchlorates into harmless chemicals. Many toxin eaters exist - like the life recently discovered in fog that eats poisonous formaldehyde: everythingisamazing.substack… 3/
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So, CAN it be done? Maybe - but it'd take time. Maybe a lot of time. Maybe centuries of biological action? We're not just instantly rocking up and getting building like a good city-builder game. It's going to be one hell of a challenge for (distant?) future colonists.
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Anyway, there's more than enough stuff in the real world (and universe beyond it) that's absolutely real AND mind-blowingly cool. If you think so too, you might find my newsletter mostly tolerable*. It's free to sign up: everythingisamazing.substack… *Yes, I'm British.
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Update - a useful link from NASA here!
Replying to @Mikeachim
NASA Ames Research Center (ARC) nasa.gov/general/detoxifying…
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And a helpful deep-dive into the effects of perchlorates on human biology...
Replying to @Mikeachim
I go into this in this thread. Basically as long as humans pack a pretty decent quantity of hypothyroidism meds even a bad exposure will be fine.
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Since this blew up and I'm getting a fair amount of assumptions flung my way: - I'm not saying a Mars colony is impossible. I don't know that, & as a space enthusiast, I wouldn't want to believe it. - I don't think it should be Fix Earth vs Explore Space. Doing both is possible!
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Also, if anyone wants to read about those formaldehyde-guzzling fog microbes without having to click through to my newsletter, this might help:
I don't want to alarm you, but it turns out John Carpenter was right: THERE'S SOMETHING IN THE FOG. But it turns out it's here to help us! Welcome to the fascinating new science of smog-chomping bacteria, fog harvesting and hyper-quick ecosystems. 1/
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Sort replies: Relevant Recent Liked
Replying to @Mikeachim
Isn’t this a pretty basic engineering problem to solve? Cover with engineered topsoil suitable to life. We’ll be expanding slowly anyway, biodome by biodome.
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Replying to @Mikeachim
My favorite fact about this problem: perchlorates are an oxidizer resource if you crack them. Same chemistry that makes the dust toxic gives you oxygen and propellant feedstock. Still a huge remediation challenge, but it cuts both ways.
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Replying to @Mikeachim
That can’t be true: Matt Daemon grew potatoes there!
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I KNOW, RIGHT. From the little I know, that's still possible based on how the story went - Andy Weir knows his stuff! The perchlorates are just a nasty complication to it.
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Replying to @Mikeachim
Going to Mars is a pipedream unless the technology vastly improves that means speedier communication and travel that's before we think about sending humans
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Replying to @Mikeachim
Mars' lack of nitrogen is another major problem overlooked by fantasists. Tho oxygen is abundant on Mars, N is not*, and for earth-like air you need 4X more N than O. *Highly reactive O2 bound readily into minerals; nearly inert N2 did not, so most of Mars' N escaped into space.
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Replying to @Mikeachim
the absurdity of trying to fix this versus not even trying to fix the environmental problems we are having on Earth.
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Replying to @Mikeachim
Depend on the concentration
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Replying to @Mikeachim
Don't forget it doesn't have enough gravity to maintain bone and muscle. If you want to live somewhere else, fusion powered superstructures are possible. Colonizing Mars isn't.
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Replying to @Mikeachim
@grok what’s perchlorate
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Replying to @Mikeachim
Ni en 100 años estaremos allí.
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