Our lab investigates the molecular mechanisms that underpin the antibody-based cellular immune response to viral infection.
Scripps Research, La Jolla, CA
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Why do some antibodies get NK cells to kill HIV-infected cells and others don't? We think it's geometry: nanometer-scale spacing of Env and bound antibody.
New 5-yr NIAID R01 to measure it with MINFLUX, then design antibodies to spec.
Hiring. Details 🧵
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Full story from @SanDiegoBiomed: sdbri.org/news-entry/the-mur…
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We're hiring:
• Postdoc or staff scientist to lead the MINFLUX/super-resolution imaging
• Technician for cell culture, cell assays, microscopy support — ideal for a recent or soon-to-be grad
Interested or have leads? dmurin@sdbri.org. Institute ads posting soon.
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Funded by a five-year, $4.7M R01 from NIAID/NIH (R01AI198054). This is our lab's second grant ever and by far the largest — a real milestone for a young group.
With co-PI @ Daniel Montiel Garcia and co-Is Lars Hangartner & Andrew Ward at Scripps Research.
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Then the inverse of how antibody discovery usually works: feed those measurements into ML models that predict which configurations drive the strongest ADCC, and use them to design synthetic nanobodies computationally. A blueprint instead of a lucky find.
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Those distances are far below the resolution of conventional microscopy. To see them we'll use MINFLUX nanoscopy, which localizes single molecules to within a few nanometers.
Direct follow-up to our recent work showing a key NK cell antibody receptor sits in pairs.
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1/ Why do some antibodies get NK cells to kill HIV-infected cells while others barely work? Nobody's been able to predict it.
Our hypothesis: geometry. The nanometer-scale arrangement of HIV Env and the antibodies bound to it on an infected cell's surface.
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The Murin Lab posts its first paper! Congrats to Dr. Ross on completing this fantastic and impactful work detailing the spatial location of CD16a within the NK cell ADCC immune synapse using MINFLUX nanoscopy.
@Abberior @scrippsresearch @SanDiegoBiomed
biorxiv.org/content/10.1101/…
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The Murin Lab is in Oslo, Norway! At the gorgeous Scandic Holmenkollen Park Hotel. Excited to meet new friends in the @nkcell field and share what we’ve been working on.
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TheMurinLab retweeted
Here at SDBRI, the Milner lab focuses on the design of new therapeutic approaches aimed at fighting multiple sclerosis!
Read more at @sd_biomedical instagram.com/p/CvN8hIyvdbg/…
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TheMurinLab retweeted
Have you ever heard of cachexia?
Here at San Diego BioMed scientists are working to understand the complexities of cachexia with the aim to develop new therapies and treatments.
Read more at @sd_biomedical instagram.com/p/CvdYpzOP5ti/…
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TheMurinLab retweeted
San Diego BioMed Journal Club season has started!
Read more about this week's session at @sd_biomedical instagram.com/p/Cv0kTTivTLw/…
Link to this week's read jamanetwork.com/journals/jam…
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TheMurinLab retweeted
Meet Dr. Cecilia Marcondes!
Cecilia is an Associate Professor here at San Diego BioMed.
Read more about Cecilia at @sd_biomedical instagram.com/p/Cu5Q9wlv11v/…
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TheMurinLab retweeted
SDBRI’s environment is designed to promote collaboration across disciplines encouraging innovation and teamwork.
Read more at @sd_biomedical instagram.com/p/CuaUbINSZGD/…
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TheMurinLab retweeted
Following policies, procedures, and the law – is it enough?
Read more at @sd_biomedical instagram.com/p/CuAnZQiy8ue/…
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TheMurinLab retweeted
June is Alzheimer's Disease Awareness Month!
Read more at @sd_biomedical instagram.com/p/CtZqve_vL1e/…
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TheMurinLab retweeted
Here at SDBRI the Davies lab’s aim is to understand how the immune system prevents T1D in some people, and why some people have defects in their immune system that lead to T1D.
Read more at @sd_biomedical instagram.com/p/CtxN76WvDoZ/…
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TheMurinLab retweeted
Meet and welcome Dr. Daniel Murin!
Daniel is an Assistant Professor here at @SanDiegoBiomed and an Adjunct Assistant Professor at @scrippsresearch!
Read more about Daniel at @sd_biomedical instagram.com/p/CtMyqFdPOe_/…
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TheMurinLab retweeted
Patrick working in the @MurinLab analyzing Natural Killer cell activation!
#sandiegobiomed #research #nkcells #lab #biomedicine
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TheMurinLab retweeted
San Diego BioMed Intern appreciation!
Read more about Albert and his work in the Binley Lab at @sd_biomedical instagram.com/p/Csou4uQPBw3/…
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