We are a neuroscience laboratory interested in neural mechanisms of social communication.
Princeton, NJ
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We discover an oscillatory circuit in the fly’s nerve cord that is under inhibition from the brain in the far condition - strong sensory input when males are close to females relieves inhibition and simultaneously drives the oscillatory circuit, generating rich, complex song.
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We show that male flies switch between two types of song throughout courtship (complex vs simple), dependent on context - whether they are near vs far from the female. And, we uncover the circuit mechanisms underlying this amazing flexibility.
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Proud to announce that the incomparable Talmo is now Dr. Talmo Pereira. Join his new lab @salkinstitute to apply deep learning in a wide variety of biological contexts. Congrats Dr.!
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We had already mapped the connectome of early auditory circuits -biorxiv.org/content/10.1101/… – we now extend this to the new intermediate neurons and connect the map to a few known higher-order feature detectors. 4/6
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Fly song consists of switches between 2 modes (or syllables). In collab with Dickson lab @HHMIJanelia, we generated genetic lines to label ~50 types of intermediate neurons. We then recorded from these and found they have diverse preferences for song mode. 2/6
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Go to FlyWire.ai to try out proofreading - piped.video/watch?v=LH4iovmb…. 5/n
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FlyWire has already been used by @DudiFly et al. to reconstruct circuits underlying a persistent internal state: biorxiv.org/content/10.1101/…. 3/n
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Drosophila neuroscientists, join the new community at FlyWire.ai to trace your brain circuits! Together with @SebastianSeung and the amazing FlyWire research team, we segmented all the cells in a whole-brain EM stack by AI. 1/n
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Please contact us if you want to use sleap.ai for your research - we are happy to help you get started! We also welcome feedback as we continue to improve the software! 3/3
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Here are some of our clinical grade COVID test swabs coming off the line that @talmop printed. These are headed for the local hospital. 2/2
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We're piloting an effort to print COVID test swabs for local hospitals! Get in touch if you are doing the same. We want to swap info on IRB, scale-up, and coordination with hospitals. H/t to @USF for their awesome open design and to @physbiofunc for contributing funds. 1/2
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Excited to announce our latest paper linking song feature detection to sex-specific behaviors in flies in @CurrentBiology: cell.com/current-biology/ful…. Congrats to @DudiFly + Jan, Stephan, and Georgia!
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Thanks to our speakers for fabulous talks on innate behaviors and sensorimotor pathways at the BRAIN Initiative 2019 meeting. @MishaAhrens @AndrewLeifer
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