Researching how exercise, nutrition and aging alter musculoskeletal function
California
Based in United States
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- Followers 32,460
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After six days of loading, we measure the size and strength of the ligaments by loading them into the 3D printed grips that we designed for our @instron material tester.
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Our pre-clinical studies are still going strong too. If you ever wonder how we exercise our 3D engineered human ligaments, here my student Jared Ong is loading them into their gym (bioreactor) and placing them in the incubator.
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I'm super excited to start playing with our new @KangaTech_ KT360 RFD. We are hoping that this will help us develop the next generation of training plans to reverse tendinopathy. Studies on PHT, PT, AT, shoulder, and elbow programs are all in the works.
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Check out our latest paper. This one is on training the tendons of the fingers.
rdcu.be/d1zMi
If you want a synopsis of the paper, check out this YouTube video.
youtu.be/XXrDQ8PCAmI?si=qBZ_…
Comments always welcome
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25 years ago today, I got into my baggy pants and married the woman of my dreams. Happy anniversary @BarbMiltner1
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The argument for a Kelpie is strong. I love watching our beautiful Roxy in this video
youtu.be/DZmASddJ0Co?si=teGN…
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EHL update #7 to engineer ligaments we fill out culture plates with Sylgard rubber. Here I am putting 1.5ml into over 500 plates.
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EHL #6 for the first 48+ hours, the cells we isolate are rounded but attached. If everything I knew was just destroyed, I would stay rolled in the fetal position until I knew I was safe too.
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EHL update #5 if you haven't over-digested the tendon you see these: cells held together like beads on a string within the fibrillin matrix that isolated them from the collagen matrix.
Now we wait and see how the cells grow.
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EHL update#4. This is something very few people have ever seen. If you grab the corner of the collagen, all those pieces stick together (even though they were out together just 20 second before)! Collagen is super sticky. This is why you never see any free ends of collagen.
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Engineered human ligament (EHL) update. After digesting overnight, this is what we are left with. Remember, I chopped the tendon up into about 8 pieces. I took everything out of the two tubes and this is what is left. The collagen that wasn't broken down (we want the cells).
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The first thing we have to do is get the cells out of all that collagen. For this, we put the ligaments into collagenase and let it slowly break down the matrix overnight.
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Thanks to the generous person who donated their ruptured ACL and the remaining healthy tendon great to our research. From this one donation, we will be able to make more than 1000 engineered human ligaments.
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Congratulations to my outstanding undergraduate student Ariana Banerjee for winning a presentation award @ABRCMS. This is always one of the best science meetings of the year.
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Last, she shows where you find you favorite tendon genes.
This is a truly beautiful paper that we hope you enjoy.
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In this paper, @SteffenDanielle shows that there are two DISTINCT populations of fibroblasts in tendons: one in the middle (making Col1) and the other on the outside (making Col3).
If there is Col3 in the middle of your tendon, it is regenerating.
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Heading back to Davis for Alec to defend his thesis. If you are interested in how inflammation affects tendons/ligaments this is a can't miss seminar
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The coolest thing is that she identified JAK/STAT signaling as preventing increases in tendon CSA and mechanics. Using our human engineered ligaments we then show that inhibiting JAK1 increases tendon collagen and mechanical strength.
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Congratulations to these outstanding new doctors @SteffenDanielle @surajjpathak and Alec Avey. I could not be prouder. Keep your eye out for their upcoming papers.
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Another great year of EXB124. This group brilliantly applied what they learned in the classroom to make themselves faster and stronger.
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We've been running our @opentrons robot ragged doing high throughout screens. Hope to have some really interesting data soon
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Not really a midterm in the "Physiology of Maximal Human Performance" without reference to @ThatBigRon. How would you do on this question? Key available soon.
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Loving the @Finnair customer service here in Helsinki. Stuck here for 7 hours with no one to help
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From the amazing Kent Monkman exhibit today in Toronto 🇨🇦. Well wishes from those of us who appreciate Miss Chief
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I come home for a couple of days and who is in the newspaper but one of my high school classmates Dean Barnes making news with his hockey card collection featuring incredible players of color.
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Hey @mf_navedo, if anyone says that you weren't your usual charming self today I might know why!
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Congratulations to @OrthochickMD on being honored with the Keynote Lecture at the 2023 @ORSsociety national meeting.
She is a legend and this is an apt honor for all that she has done as a mentor.
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Nice talk from Theo Bellefroid from @louvainlaneuve and the lab of @LDeldicque on his work here @ucdavisbiology on how eIF2a affects muscle protein synthesis.
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If it takes you 2s to do a repetition, you move from the peak to the red arrow in the healthy part of the tendon. The result of that there is less stress shielding and more load goes through the scarred region.
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I really love what we've built here @ucdavisbiology. Not many tissue culture facilities look like this. A @LonzaGroup electroporator, a @Lumedicaimaging OCT, and our amazing @instron tensile tester with 3D printed grips. Everything you need to engineer strong ligaments.
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Collected muscles from 24-month-old move this morning with @surajjpathak. Which genre do you think we overexpressed in the 2nd, 4th, and 6th muscles?
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Why do sports continue to hide behind "we can't quantify concussion" when @corticalmetrics can and does exactly that?
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7 Pendulum weight machines by @rogersathletic +
1750lbs of steel from @RepFitnessEquip =
1 very happy lab.
First IRB is already submitted.
ALT Functional molecular biology gym
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2. The improvement in brain function corresponds with the metabolism of a potential neurotoxin.
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Another wonderful talk from @mackinprof. Great to see scientists who are willing to change their minds as data develops
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Best in the world @LouiseMBurke talking about low CHO versus other diets on elite endurance performance
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Within 7 days without acetyltransferases, muscle force goes to zero. Acetylation is essential to muscle function
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Wonderful talk on how muscle grows in response to load by @HornbergerLab. Beautiful work that is changing how we think muscle grows
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It's that time of year here in Northern California. First batch (3kg) of figs from our tree! Recipe suggestions are always welcome.
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Congratulations @Nkechi_ChidiO! Wonderful to have you in the lab. It won't be the same without you in the lab.
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Wonderful to have @runcamille and @ConorHolt3 in the lab today. Super cool to hear how her injuries drove her to science and how she now uses that science to minimize injuries while running ultras better than anyone else. Good luck in the @wser!
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Here's to the latest version of the lab and to all the former lab members around the world. Thank you for choosing to be a part of my family.
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Great job by Ezequiel Ponce, an undergrad in my lab, presenting his work on how the post-transcriptional regulation of dystrophin is modified by a ketogenic diet. 💯
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Keeping with @ucdavis tradition, the newly minted Dr. @Nkechi_ChidiO celebrated by banging the gong. Congratulations Nkechi! We are immensely proud of you.
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One week from today I get to do the best part of my job. I get to sit and watch an incredible student become a doctor. Interested in hormone effects on tendon/ligament function? You will really enjoy this. ucdavis.zoom.us/j/9522678424…
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.The guys in the clear rain coat at the back is my grandpa (Tim Baar). This was the last movie he worked on (special effects). His first was the Wizard of Oz. Split in the middle with an Oscar for the Time Machine. Amazing career.
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Nice to come home to my first shipment of @KetoKind. I am biased as a Scientific Advisor, but really impressed by the quality of this organic, vegan, high protein, keto meal replacement.
ALT Keto Kind Protein Drink
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Testing human engineered ligaments today. The new @instron Is working beautifully.
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Hey @AltraRunning, I have a #sciencenerd question for you. Am I the only person who runs in these shoes who has shown that running is a TOR INhibitor?. Never a more aptly named shoe. ncbi.nlm.nih.gov/pmc/article…
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Working in the office, so I have to make do with what's at hand, but this is the isometric we do for the UCL. Depending on your strength, you can work up to a cast iron fry pan (what I use at home). High tech rehab here.
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It is great to be able to host lab parties again. This one to thank @agata_moss and @HenningLanger for 3 wonderful years and to welcome Dr. El Essawy back from Egypt.
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Twelve years ago, I carried this little girl into our lives and she took over our hearts like nothing we had ever known. Yesterday, I carried her to her last sleep. Thank you @ucdavisvetmed for helping us give our lovely girl a quite and gentle sendoff.
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Please RT & help me get the word out. I am actively looking for a postdoctoral fellow interested in working from humans to cell culture to understand how varying nutrition affects muscle growth and function. Come join a diverse group of scientists in a beautiful part of the world
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Looking for a postdoctoral position? Great opportunity to come to Davis to work in a leading bioengineering lab with @kentleach5. Wonderful mentor and person to help you get your own lab moving forward.
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We @ucdavisbiology are saddened by the loss of Edmund Bernauer youtu.be/j1YOWUcnmJs. Joined the faculty in 1962 and played a essential role in the development of Exercise Biology here.
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Running stress-relaxation tests on patellar tendons in the lab today. Beautiful curves. Note that 80% of the relaxation happens in the first thirty seconds. That is why we hold isometrics for thirty seconds to try to fix an injured tendon.
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Congratulations to all @ucdavisbiology graduates and an extra special thank you to the wonderful undergraduates who have done such incredible work in the lab these past few years: Nicole Baker, Jed Obra, and Ryan Lin!
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I don't know if the hangboard in the lab has the super small ledges, but @SteffenDanielle, @HenningLanger, @surajjpathak and @KarineSchaal I sense a good summer competition here.
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