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🗞️Our September issue is live!✨Read about trained immunity driving inflammaging; senomorphic potential of CDK4/6 inhibitors; muscle grafts mimic exercise benefits; mtDNA drives ovarian inflammation; aging diseases dominate global health & much more!
nature.com/nataging/volumes/…
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Online now!✨@kezhang2021 @xingjchen7 @f_monticolo @Salvato88775199 et al pair Raman imaging with spatial and single cell transcriptomics in aging and repair, and identify a lipid-linked Raman signature of p21+ cells @JianShuLab nature.com/articles/s43587-0…
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📎 And read the News & Views written by Shuai Ma & Jing Qu nature.com/articles/s43587-0…
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📎And now read the associated Research Briefing: nature.com/articles/s43587-0…
Online now! @EnriqueGab, @gsotoheredero et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice @MMittelbrunn nature.com/articles/s43587-0…
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Could molecular diagnostics advance our understanding of Alzheimer's? Applications are now open for the 2026 MDx Impact Grants, supporting research on molecular markers of neurodegeneration using Seegene's high-multiplex PCR technology. go.nature.com/4r6o6KG
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Online now! Cerrato et al propose a consensus roadmap towards precision senescence medicine, emerging from the SENESCENCE2030 meeting in Coimbra, Portugal earlier this year @marc_dema nature.com/articles/s43587-0…
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Online now!✨@anamikaa_yadav et al develop a framework to quantify tissue structural aging, without training on chronological age, using GTEx histology image data, finding distinct and coordinated organ aging trajectories @Sanjusinha7 @sbpdiscovery nature.com/articles/s43587-0…
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📎And now read the associated Research Briefing nature.com/articles/s43587-0…
Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan nature.com/articles/s43587-0…
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Online now! @EnriqueGab, @gsotoheredero et al identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. Blocking this axis improves healthspan in aged mice @MMittelbrunn nature.com/articles/s43587-0…
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Online now! In a World View, primary care physician Dean Ariel reflects on how conversations about geroscience unfold in his clinic, amidst the evolving landscape of public engagement with aging research nature.com/articles/s43587-0…
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Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan nature.com/articles/s43587-0…
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Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice @Marc_dema nature.com/articles/s43587-0…
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✨Rajesh et al also report an unexpected role for the cell cycle regulators cyclin D1 – CDK6, as regulators of SASP via DNA damage and cGAS-STING. Blocking this pathway with palbociclib improves motor function and frailty in aged mice @AdamsBioAging nature.com/articles/s43587-0…
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📎Liqin Wang & Rene Bernards discuss both studies in a News & Views nature.com/articles/s43587-0…
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Register now for Reframing Precision Medicine: Innovation to Implementation, a flagship Nature Conference in London from 13–15 Oct 2026. Learn more at go.nature.com/471AdQb?utm_so…
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🗞️Our August issue is live!✨Read about fructose drives metastasis from senescent ovarian cancer cells; dietary valine restriction improves mouse healthspan, 5 blood proteins predict MASLD up to 16 years before onset & much more
nature.com/nataging/volumes/…
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📎Now read the associated News & Views from Maz Divangahi & Katherine King nature.com/articles/s43587-0…
Online now!✨Mu, Barthez, Feng, Chen, Wang et al report that trained immunity links hematopoietic stem cell aging to age-associated inflammation nature.com/articles/s43587-0…
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Online now!✨Cole et al identify fructose as a component of the therapy-induced SASP in senescent ovarian cancer cells and show that it reprograms cancer cells in paracrine, promoting detachment and metastasis @airdlab nature.com/articles/s43587-0…
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✨SenNet Collection✨Browse all the papers from the SenNet project across the Nature Portfolio mapping senotypes, developing tools, and discovering biological & translational insights nature.com/collections/ffadj…
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