GLP-1 metabolic adaptation: I have patients at a normal BMI: 23-25 on maximum GLP-1 after 5 years, who are no longer responding ie starting to regain weight, food noise has returned, and have no side effects. Semaglutide 7.2 mg. Anyone else seeing this?

What happens when you stop GLP-1….you regain the weight

As a BIG fan of both…. Bariatric Surgery is more cost effective than GLP-1 gut hormone anti-obesity based medications

The lasting effects of GLP-1 medications and gastric bypass surgery, when comparing independent studies, reveal that 60% of weight is regained after 1 year when medication is stopped but it takes surgery patients 20 years to regain only 7% of their BMI on average.

The “Wild West” of GLP-1 medication usage abuse. Self-prescribed meds due to in appropriate accessibility open the door to over-usage type complications. “The medical system has lost control” share.google/EbDnlnXKmYO2Wiu…

Bariatric Surgery and GLP-1 based anti-obesity medications work together to achieve the most benefits for bothe weight loss and long term control.

Come join the @YaleSurgery Bariatric Surgery Team and all the bariatric programs as we raise awareness for #obesity as a disease and raise funds to support research and education - Come walk and meet the dedicated doctors surgeons medical team members and patients.

Presenting the impact of bariatric surgery on MASH at the 12th Paris MASH Meeting at the historic Institut Pasteur. Bariatric surgery as a powerful treatment for advanced metabolic #liver disease.

Cardiovascular benefits of obesity therapies: an overview of obesity medicines and metabolic bariatric surgery Metabolic bariatric surgery vs GLP-1 receptor agonists: what about cardiovascular outcomes? ❤️ The evidence is increasingly compelling: 🔹 Metabolic bariatric surgery (MBS) shows a strong and durable association with fewer MACE, HF events and deaths, with observational HRs often around 0.4–0.6 vs non-surgical care. 🔹 GLP-1 RAs have the strongest randomized evidence: ↓ 3-point MACE, including in obesity without diabetes (SELECT), with additional benefits in HFpEF symptoms and function. 🔹 Direct real-world comparisons often favor MBS for MACE/mortality, but residual confounding remains a major limitation. 👉 The key unanswered question is no longer “Does weight loss improve CV outcomes?” but rather: Which strategy, for which patient, and with what long-term durability? We urgently need contemporary head-to-head randomized trials: MBS vs modern incretin-based therapies. #Cardiology #Obesity #GLP1RA #BariatricSurgery #HeartFailure #MACE #CardiometabolicHealth #CKM heart.bmj.com/content/early/…

Retatrutide, an investigational triple hormone receptor agonist that shows promise for weight loss in ongoing phase-3 clinical trials, is being sold openly across the internet and prescribed by licensed physicians online and in diverse clinical settings across the US, investigations have found. The phenomenon of such easy access to a drug that's not approved anywhere for any indication is arguably without precedent. Patients are discovering the drug — a GLP-1, glucose-dependent insulinotropic polypeptide, and glucagon agonist — through social media, purchasing it from vendors online, and arriving at clinic appointments either asking about it or disclosing they are already using it. News reports state that everyone from “shadowy online vendors” to physicians and nurses is illegally promoting the drug before it receives the FDA approval. Tap the link to read the full story. mdsc.pe/4akBi7z

RT @DrJesseMorse: 🚨 A Michigan man sentenced to prison after selling “research-use only“ peptides online. This should serve as a warning t…

Cool pre-clinical weight loss drug from Korea. It hits 4 receptors: GLP1 - GIP - human growth hormone (hGH) - activin type II receptor (ActRII). It ~matches tirzepatide for weight loss, with more fat loss and less lean mass loss. 99.5% of weight loss was fat:

Dave- You and your colleagues have produced outstanding research in the past. Always honored to lend any support.

Everyone alive at the time knows where they were what they did and ho they felt when the towers fell on 9/11. It was the saddest of days. There was fear. …but we united as a people. Tragedy and crisis bring good people together. Out of this horrible loss, we need to reach deep for the goodness we have gained and hold onto the ideals of freedom and justice that unite ALL Americans who love America 🇺🇸

I posted this in 2006 when people believed that diet nd exercise were an effective treatment for #obesity. Despite life-changing Bariatric Surgery results it took the acceptance of GLP-1 medications to convince the public otherwise.

Why do people with type 2 diabetes often lose less weight with GLP-1–based therapies? My first paper as an @AstraZeneca employee uses mathematical modeling to suggest that GLP-1 induced glycemic improvements may reduce urinary glucose excretion and energy expenditure, partially offsetting negative energy balance—particularly with background SGLT2 inhibitor therapy. Preprint: biorxiv.org/content/10.64898…