Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.
Boston, MA
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Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum.
Xia B, Han M, Park I, Perrimon N. Proc Natl Acad Sci U S A. 2026 Sep 22;123(38):e2616684123. doi: 10.1073/pnas.2616684123. Epub 2026 Sep 17. PMID: 42752232
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The Drosophila Secretome
Yanhui Hu1, Nahid Ausrafuggaman, Jenna Kalina, Austin Veal, Mujeeb Qadiri, Ah-Ram Kim, Norbert Perrimon
doi: doi.org/10.64898/2026.08.24.…
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Yanagawa K, Perrimon N. Extracellular vesicles in Drosophila and mammals: Conserved mechanisms and emerging functional roles. EXO. 2026;1(3):202615. doi: 10.70401/EXO.2026.0014. PMID: 42598228
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Lee, et al. (2026). Antigen presentation by CD40+ MHC-II+ astrocytes promotes CNS autoimmunity. Nature. doi: 10.1038/s41586-026-10860-6. PMID: 42557325
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In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila.
Marques et al. Elife. 2026 Aug 18;14:RP109422. doi: 10.7554/eLife.109422.
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A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor
Anja C. M. de Bruin et al.
bioRxiv 2026.07.31.742019; doi: doi.org/10.64898/2026.07.31.…
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Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses
Plung et al.
bioRxiv 2026.07.28.741058; doi: doi.org/10.64898/2026.07.28.…
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Hu, Y., Comjean, A., Gao, C., Veal, A., Yamamoto, S., Mohr, S.E. and Perrimon, N. (2026) DIOPT: the DRSC Integrative Ortholog Prediction Tool, 2026 update. Genetics. doi: 10.1093/genetics/iyag194. PMID: 42504133
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New paper: Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila. Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N. Nat Commun. 2026 Jul 3. doi: 10.1038 s41467-026-75074-w.
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New paper:
Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.
Xu et al.Nat Microbiol. 2026 Apr 30. doi: 10.1038/s41564-026-02315-5. Online ahead of print. PMID: 42062574
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New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678
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Miao, T., Liu, Y., Qadiri, M., Dasseux, A., Asara, J. M., Hu, Y., Sun, X., Pliego-Alcántara, LDC., Dibble, C. and Perrimon, N. (2026) Renal coenzyme A (CoA) production from Vitamin B5 fuels stem cell proliferation and tumor growth. Nat Commun. doi: 10.1038/s41467-026-71716-1.
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Han. M., Xia, B., Kim, A-R., Filine, E., Stoneburner, E., Miao, T., Liu, Y., Zirin, J. and Perrimon, N. (2026) Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila. PNAS. 14;123(15):e2531777123. doi: 10.1073/pnas.2531777123. PMID: 41941621
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Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134
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Lane, E., Petsakou, A., Liu, Y., Chen, W., Qadiri, M., Hu, Y. and Perrimon, N. (2026) Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis. PloS Genetics. 22(2):e1012048. doi: 10.1371/journal.pgen.1012048. PMID: 41701793
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Ewen-Campen, B., Chen, W., Tattikota, S. G., Liu, Y., Hu, Y. and Perrimon, N. (2026) The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth. doi: doi.org/10.1101/2025.06.27.6…. Nat Comm. PMID: 41593082
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Moon, Hu, Dzieciatkowska, Kim, Asara, D'Alessandro and Perrimon (2026) Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels. Nat Comm. doi: 10.1038/s41467-026-68395-3.
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Marques et al. (2025) In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila. eLife14:RP109422https://doi.org/10.7554/eLife.109422.1
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