Patrick McClure@PostdocPat

*now AssProfPat - Virologist at the University of Nottingham. Interested in detecting and sequencing viruses known and unknown in people and animals.

 Nottingham, England
tinyurl.com/Postdocpat
Joined November 2018
32 Photos and videos
When determining EVD68 cases in late 2018, we noticed CVA6 was the second most prevalent enteroviral type and thus worthy of its own study! Finally published last week, comparing cases spanning the emergence of SARS-CoV-2 @OneVirology mdpi.com/2076-0817/13/11/102…

Coxsackievirus A6 U.K. Genetic and Clinical Epidemiology Pre- and Post-SARS-CoV-2 Emergence

Coxsackievirus A6 (CVA6) has become increasingly clinically relevant as a cause of Hand, Foot and Mouth Disease (HFMD) globally since 2008. However, most laboratories do not routinely determine the...

mdpi.com
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Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018 @OneVirology @UoNLifeSci @UVRIug sciencedirect.com/science/ar…
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Highlights 1/2: 'The first West Nile virus genome from a human infection since 1937 was discovered in Uganda' 'Pan-genus polymerase chain reaction screening retrospectively detected the West Nile virus genome in immunoglobulin M-negative serum'
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Highlights 2/2: 'A novel 1200bp amplicon whole-genome sequencing scheme is presented' 'Lineage 2d genome is closely related to a contemporary local vector-derived sequence' 'Rural adult case with fever, headache, rash, vomiting, nausea, fatigue, and joint pain'
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Opening a 60-year time capsule: sequences of historical poliovirus cold variants shed a new light on a contemporary strain academic.oup.com/ve/article/…

Opening a 60-year time capsule: sequences of historical poliovirus cold variants shed a new light...

Abstract. Polioviruses (PVs) are positive strand RNA viruses responsible for poliomyelitis. Many PVs have been isolated and phenotypically characterized in

academic.oup.com
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Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in China sciencedirect.com/science/ar…
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Poliovirus that infected a Chinese child in 2014 may have leaked from a lab science.org/content/article/…

Poliovirus that infected a Chinese child in 2014 may have leaked from a lab

Samples destined for destruction at a Paris institute trigger a virological “detective story”

science.org
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A salute to the fellow clinical wombles making good use of the things they find here: 'Community-based mpox and sexually transmitted disease surveillance using discarded condoms in the global south' thelancet.com/journals/lanin…

Community-based mpox and sexually transmitted disease surveillance using discarded condoms in the...

As COVID-19 restrictions have eased, the resumption of international travel and sexual interactions at large gatherings have fueled the continued spread of human mpox beyond its endemic regions.1–3...

thelancet.com
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Patrick McClure retweeted
Neil Oldfield@NjOldfield
27 Aug 2024
Students urged to top up vaccines before term time bbc.com/news/articles/cx2n3l…

Students urged to top up vaccines before term time

Students should be vaccinated against meningitis, HPV and measles, a health authority says.

bbc.com
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Patrick McClure retweeted
Dr Emma Hodcroft@firefoxx66
27 Aug 2024
One of the reasons I've been quiet on Twitter for a few months is because I've been working on something big - something I'm really happy to share now! Pathoplexus.org A new, open-source database for pathogen sequence sharing. 👐🧬🌎 1/12

Pathoplexus | Home

Pathoplexus is a new, open-source database dedicated to the efficient sharing of human viral pathogen genomic data, fostering global collaboration and public health response.

pathoplexus.org
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Viral Olympics! 'Experts choose target pathogens for Olympic wastewater monitoring' cidrap.umn.edu/polio/experts…

Experts choose target pathogens for Olympic wastewater monitoring

cidrap.umn.edu
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Out last week, a look into some virological time capsules with @Simmonds_Lab - unused contaminated Factor VIII and IX preps from the 1970s - 90s onlinelibrary.wiley.com/doi/…

Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor...

Factor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To...

onlinelibrary.wiley.com
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some summary and extra photographs here: wcgvr.org/publications.html
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Somewhat overdue, but at last, here’s our preprint on amplicon whole genome sequencing for the four seasonal coronaviruses: Vivaldi! #seasonalcoronavirus #amplicon #OC43 #NL63 #229E #HKU1 medrxiv.org/content/10.1101/…

‘Vivaldi’: An amplicon-based whole genome sequencing method for the four seasonal human coronavir...

Prior to the emergence of SARS-CoV-2 in 2019, Alphacoronaviruses 229E and NL63 and Betacoronaviruses OC43 and HKU1 were already established endemic ‘common cold’ viral infections. Despite their...

medrxiv.org
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Many thanks as always to some great colleagues for helping bring this together, in particular Stuart Astbury, Nadine Holmes, @mattloose @Theo_Tsoleridis! @OneVirology @UoNLifeSci @DeepSeqNotts
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And huge thanks to @CovidGenomicsUK for funding this work!
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