McAfee Professor of Engineering @MIT; Co-Founder & CTO at Unreasonable Labs; AI-Driven Scientific Discovery

Cambridge, MA
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate. Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in. The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material. The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms. A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts! A few lessons we learned: ▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument. ▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition. ▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
AI for science is one of the greatest positive forces we have, and I cannot think of anything more human than to understand nature and to use the power to create new technologies that improve our lives, civilization and allow us to reach beyond.
Article

Recursive Meta-Intelligence

We built a recursive AI that creates its own scientific instruments, turns them into a world inhabited by a massive agent ecology, which then reasons across vast, nonlinear spaces of possible physical

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Markus J. Buehler retweeted
Incredibile. AI swarms spontaneously grow scale-free topologies with a few dominant hubs, the Barabási–Albert physics of preferential attachment! Local interactions + rich-get-richer produce the long-tailed degree distribution and information brokers with no central planner. This self-organization without a central planner is the same class of emergent phenomenon seen in many physical systems like phase transitions, self-organized criticality, and spontaneous symmetry breaking where purely local rules generate global structure, information brokers, and efficient long-range integration.
Fascinating AI swarm dynamics: a few agents spontaneously emerge as highly connected hubs, while most remain locally connected. The swarm develops a strongly heterogeneous interaction topology with a long-tailed degree distribution - an emergent organizational structure arising from initially decentralized local interactions. There is no central planner assigning roles; the swarm builds its own coordination architecture, with information brokers and increasingly global integration emerging from local behavior.
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This is a first! The beginning of some very interesting possibilities - your self-driving robot (Tesla) integrated with your team of agents that work with other parts of your ecosystem
Grok @Bot now in your Tesla!
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U.S. News just ranked MIT #1 among National Universities for the first time, after several years at #2. A great testament to the amazing students, staff, and faculty who make this place so special. It’s a magical place, and we are fortunate to call it home and share our work with the world.
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Markus J. Buehler retweeted
incredible, the future is most certainly here.
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate. Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in. The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material. The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms. A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts! A few lessons we learned: ▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument. ▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition. ▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
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Markus J. Buehler retweeted
Two fascinating studies. As a biologist, I get goosebumps thinking about this, even though I had anticipated something of the sort. Especially stigmergy, the division of labor, and an environment that preserves the traces and results of past activities strongly remind me of certain biological systems found in ecosystems. One agent creates something; another encounters it, modifies it, and thereby opens up new possibilities for those who follow. The environment becomes part of the collective memory. 1 / 2
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate. Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in. The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material. The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms. A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts! A few lessons we learned: ▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument. ▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition. ▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
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The day matter learned to hear
I made a vinyl record from some of my music - taking compositions that had mostly existed as digital recordings and turning them into a physical object. Incredible to hear the music encoded in grooves and played back mechanically in analog form. If you want to listen, the playlist is linked below. About the music: ▶️ The pieces move between piano, electronic and experimental composition. ▶️ The compositions draw on ideas ranging from proteins and biology to topology, fracture and more abstract sound worlds. Pieces include: Deep Aria - Protein Antibody in E minor - Koto of Topology - Counterpoint Through Fracture, and others
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Fascinating AI swarm dynamics: a few agents spontaneously emerge as highly connected hubs, while most remain locally connected. The swarm develops a strongly heterogeneous interaction topology with a long-tailed degree distribution - an emergent organizational structure arising from initially decentralized local interactions. There is no central planner assigning roles; the swarm builds its own coordination architecture, with information brokers and increasingly global integration emerging from local behavior.
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate. Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in. The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material. The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms. A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts! A few lessons we learned: ▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument. ▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition. ▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
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Markus J. Buehler retweeted
If you work at the intersection of AI and materials discovery, come join us at the ScienceClaw Hackathon at MIT Media Lab! 🚀 We’ll build connected AI-agent systems that combine models, tools, data, simulations, and experiments to tackle hard scientific problems.🤖
Join us at the MIT Media Lab for the ScienceClaw Hackathon, building the internet of agents for science. AI is becoming a collaborator in the real world - designing materials, creating instruments, running experiments, and connecting its capabilities with those of other agents. AI adapts as a problem unfolds - revising its reasoning, learning how to collaborate, and assembling scattered pieces of knowledge, evidence, and raw capability into solutions to some of the hardest challenges in science, technology, and innovation. Teams will connect AI agents, models, simulations, robots, cloud labs, and scientific tools into functioning systems to tackle problems in protein design, robotics, materials, manufacturing, experimental science, and beyond. The challenge is to turn ideas into tested results - and demonstrate how agents collaborating across teams and disciplines can accomplish more together. Explore how agents can specialize, challenge one another’s assumptions, learn from failed experiments, and combine their expertise to solve harder problems. Show how collaboration changes what your system can discover, design, or build. One agent's discovery becomes another's starting point. A tool built by one team enables an experiment by another. Connect your team of AIs, share a capability someone else needs, and build on what others have learned, produced, built. The ambition is an internet of agents through which scientific knowledge, tools, and capabilities can grow, evolve and be utilized across teams and institutions. 🗓️ When: October 30-November 1, 2026 📍 Where: MIT Media Lab Bring your expertise, your tools, and a problem worth solving - or find one. Help build AI that can contribute to science through what it can discover, create, and make work.
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Markus J. Buehler retweeted
Very cool Science AI agent hackathon at MIT Media lab! “The ambition is an internet of agents through which scientific knowledge, tools, and capabilities can grow, evolve and be utilized across teams and institutions.” 🗓️ When: October 30-November 1, 2026 📍 Where: MIT Media Lab
Join us at the MIT Media Lab for the ScienceClaw Hackathon, building the internet of agents for science. AI is becoming a collaborator in the real world - designing materials, creating instruments, running experiments, and connecting its capabilities with those of other agents. AI adapts as a problem unfolds - revising its reasoning, learning how to collaborate, and assembling scattered pieces of knowledge, evidence, and raw capability into solutions to some of the hardest challenges in science, technology, and innovation. Teams will connect AI agents, models, simulations, robots, cloud labs, and scientific tools into functioning systems to tackle problems in protein design, robotics, materials, manufacturing, experimental science, and beyond. The challenge is to turn ideas into tested results - and demonstrate how agents collaborating across teams and disciplines can accomplish more together. Explore how agents can specialize, challenge one another’s assumptions, learn from failed experiments, and combine their expertise to solve harder problems. Show how collaboration changes what your system can discover, design, or build. One agent's discovery becomes another's starting point. A tool built by one team enables an experiment by another. Connect your team of AIs, share a capability someone else needs, and build on what others have learned, produced, built. The ambition is an internet of agents through which scientific knowledge, tools, and capabilities can grow, evolve and be utilized across teams and institutions. 🗓️ When: October 30-November 1, 2026 📍 Where: MIT Media Lab Bring your expertise, your tools, and a problem worth solving - or find one. Help build AI that can contribute to science through what it can discover, create, and make work.
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Markus J. Buehler retweeted
Our lab is organizing a hackathon at MIT - please check it out and join
Join us at the MIT Media Lab for the ScienceClaw Hackathon, building the internet of agents for science. AI is becoming a collaborator in the real world - designing materials, creating instruments, running experiments, and connecting its capabilities with those of other agents. AI adapts as a problem unfolds - revising its reasoning, learning how to collaborate, and assembling scattered pieces of knowledge, evidence, and raw capability into solutions to some of the hardest challenges in science, technology, and innovation. Teams will connect AI agents, models, simulations, robots, cloud labs, and scientific tools into functioning systems to tackle problems in protein design, robotics, materials, manufacturing, experimental science, and beyond. The challenge is to turn ideas into tested results - and demonstrate how agents collaborating across teams and disciplines can accomplish more together. Explore how agents can specialize, challenge one another’s assumptions, learn from failed experiments, and combine their expertise to solve harder problems. Show how collaboration changes what your system can discover, design, or build. One agent's discovery becomes another's starting point. A tool built by one team enables an experiment by another. Connect your team of AIs, share a capability someone else needs, and build on what others have learned, produced, built. The ambition is an internet of agents through which scientific knowledge, tools, and capabilities can grow, evolve and be utilized across teams and institutions. 🗓️ When: October 30-November 1, 2026 📍 Where: MIT Media Lab Bring your expertise, your tools, and a problem worth solving - or find one. Help build AI that can contribute to science through what it can discover, create, and make work.
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Join us at the MIT Media Lab for the ScienceClaw Hackathon, building the internet of agents for science. AI is becoming a collaborator in the real world - designing materials, creating instruments, running experiments, and connecting its capabilities with those of other agents. AI adapts as a problem unfolds - revising its reasoning, learning how to collaborate, and assembling scattered pieces of knowledge, evidence, and raw capability into solutions to some of the hardest challenges in science, technology, and innovation. Teams will connect AI agents, models, simulations, robots, cloud labs, and scientific tools into functioning systems to tackle problems in protein design, robotics, materials, manufacturing, experimental science, and beyond. The challenge is to turn ideas into tested results - and demonstrate how agents collaborating across teams and disciplines can accomplish more together. Explore how agents can specialize, challenge one another’s assumptions, learn from failed experiments, and combine their expertise to solve harder problems. Show how collaboration changes what your system can discover, design, or build. One agent's discovery becomes another's starting point. A tool built by one team enables an experiment by another. Connect your team of AIs, share a capability someone else needs, and build on what others have learned, produced, built. The ambition is an internet of agents through which scientific knowledge, tools, and capabilities can grow, evolve and be utilized across teams and institutions. 🗓️ When: October 30-November 1, 2026 📍 Where: MIT Media Lab Bring your expertise, your tools, and a problem worth solving - or find one. Help build AI that can contribute to science through what it can discover, create, and make work.
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Learn more and sign up: scienceclawhack.ai/
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We are made of motion that cannot stop. Please join us for Amphibian Drift, an immersive exhibition and XR experience as part of MIT Future Fest, jointly with Nomeda & Gediminas Urbonas/Urbonas Studio, at the MIT.nano Immersion Lab. You will experience the relentless nanoscopic movement of molecular mechanics of an extraordinarily intricate caddisfly silk protein, from within an immersive landscape of sound, visuals, touch, and structure is created. In a world beyond what our senses can yet perceive, Amphibian Drift displays the exquisite order sustained without the possibility of choosing otherwise, an elegy of motion that will still comfort you as the molecular scale becomes strangely personal. Something of that encounter will follow you back into ordinary life: a deeper intimacy with matter, and a different feeling for what it means to endure. October 2–3, 2026 11am-5pm MIT.nano Immersion Lab, 12-3207, 60 Vassar Street, Cambridge, MA Registration details in reply.
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📅 🚀 It’s GO time! The #S27MRS Call for Abstracts is officially OPEN! Share your work, get feedback, and connect with the global materials community in Seattle.
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Rapidly design your own proteins with this new pipeline
The ESMC and ESMFold2 models are now on Huggingface! You can now install it directly from PyPi or from huggingface/transformers v5.16.0. As a part of this, we officially are releasing support for our fused Triton kernels and FoldCP in partnership with @nvidia!
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Random Access Memories
“Once you free your mind about the concept of harmony and of music being 'correct,' you can do whatever you want.” - Giovanni Giorgio Moroder, but his friends call him Giorgio
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Markus J. Buehler retweeted
I would argue that there is nothing more interesting than this research line today
We built recursive meta-intelligence, an AI that creates its own scientific instruments, turns them into persistent worlds that an agent ecology with hundreds of AIs inhabits, and uses those worlds to discover mechanistic principles in one of the hardest classes of physical problems: how complex hierarchical materials (nested structures of matter that give rise to new function through organization) evolve and fail. The AI reasons across enormous spaces of possible physical trajectories, where every rupture changes what can happen next, and compresses those histories into principles (which humans can understand and design with) - complex chains of causal events, highly nonlinear, and intricate. Scientific superintelligence is tangible here - machine-scale exploration opening cognitive channels into complexity that has been extremely difficult for humans to traverse directly. AI builds the spaces in which its next level of reasoning becomes possible; a representation becomes an instrument, the instrument becomes an executable world, and that world becomes the substrate for further intelligence. Intelligence then grows by constructing new spaces to think in. The task we explored started from a seemingly simple prompt to explore a biological material system - the AI then chose the representation, mechanics and experiments, built a fracture laboratory to push materials to their limit, tested hypotheses and generated scientific conclusions. The swarm explored a combinatorial universe in which architecture controls function and every rupture changes the future state of the material. The AI discovered a compact principle that defines how multiscale material architecture can program the evolution of failure. Material placement and geometric order determine how forces redistribute, whether damage cascades or remains distributed, and whether function survives substantial flaws. For this discovery to happen the AI had to reason across long path-dependent histories, simulate alternative futures and compress them into generative invariants (model-based causal reasoning, counterfactual simulation and temporal abstraction applied to an evolving physical world). It is incredible to witness this transition to a new form of intelligence and capability through scaling swarms. A lot of positive will come out of this because it expands the human epistemic horizon as AI can traverse thousands of possible histories and return mechanisms compact enough for us to understand, test and build from. Intelligence compounds through its artifacts! A few lessons we learned: ▶️ Learning and discovery are flows through spaces of possibility. Early work has shown how backpropagation flows through parameters, reinforcement learning through action and consequence, and autonomous swarms through representations, instruments and executable worlds, bringing it all together. Flows create structure; structure redirects future flows in the recursive instrument. ▶️ Nonlinear physics actually defines a larger principle, where high-dimensional dynamics generate stable invariants; invariants become effective variables; those variables become the substrate for a new level of cognition. ▶️ Recursion then becomes level creation - one possibility space compresses into a principle, and that principle opens a larger space above it.
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AI is one of the greatest positive forces we have, and I cannot think of anything more human than to understand the world - and to use that power to improve our lives, civilization and allow us to reach beyond what we even dared to imagine.
I love this guy @JensenHuang! This is why we should never lose hope: there’s always a silver lining to every dark side. We find our true force & light to guide us in the age of AI. But, the dark side must be held accountable for using the most powerful weapon of control: FEAR!
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