I had to recover my X login to share our preprint! Watch this space - exciting other papers to soon follow! biorxiv.org/content/10.1101/… we have been working very hard to "crack the CIA code"

The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal...

The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental proces...

biorxiv.org
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In this paper, we determine that the Targeting Complex Recognition (TCR) motif recently identified through a collaboration with my lab and @AJPierik's lab binds at the interface of Cia1-Cia2 complex in the cytosolic iron-sulfur cluster targeting complex (CTC)
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It was a surprise to us that the Cia2 subunit of the targeting complex makes key interactions, as the current working model of CTC function delegates Cia2 to a Fe-S binding module. This discovery has 3 major implications for understanding this complex system.
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1) the Cia2a paralog of Cia2 found in animals is possibly not a specific assembly factor for IRP1 but likely binds to and facilitates maturation of additional clients
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2) we determine that a disease causing mutation in Cia1 results in disruption of the Cia1-Cia2 complex, and as a result, client recruitment and maturation

Mar 29, 2025 · 7:30 PM UTC

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3) we find some of the first, direct biochemical evidence for role of the CIOA3/Nar1 protein in cluster trafficking. I hope you enjoy the paper! we are very excited to have this out there, if only in preprint form for now
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Replying to @Prof_Perlstein
So nice ..thank you
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