Opinions are my own and not the views of my employer
Miami, FL
- Tweets 129
- Following 163
- Followers 135
- Likes 203
PrudencioLab retweeted
Our work on #Microglia and #TDP-43 in early #brain development is finally out @NatureNeuro! Congrats to the brilliant @AnneCompagnion and thanks to the many collaborators!!! Enjoy the read!! :) nature.com/articles/s41593-0…
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PrudencioLab retweeted
Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43 | Science Advances science.org/doi/10.1126/scia…
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A team of NIH-funded researchers shed new light on how short RNA molecules prevent abnormal clumping of the TDP-43 protein. These findings, in cell and animal models, suggest RNA-based therapies could one day be used to treat diseases like ALS and Alzheimer’s disease.
Learn more: bit.ly/43YLRtc
ALT A neural cell image with blue branching structures on a light blue background. Text overlay reads: "Tiny RNAs show promise for protecting brain cells. NIH-funded research finds short RNA molecules can stop harmful protein clumps, offering a potential new path to treat ALS and related dementias." NIH logo is at the bottom.
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TDP-43 subtypes shape transcriptomic signatures in Alzheimer's disease biorxiv.org/content/10.64898…
@PrudencioLab
Excited to share our new transcryptomics study in AD where we use quantiative measures of pathological pTDP-43 and pTau to discern changes resulting from each pathology.
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PrudencioLab retweeted
Dr. Timothy Miller, 2023 Rainwater Prize winner and Tau Consortium member, leads this @JAMANeuro article reporting long‑term Phase 3 and open‑label extension results in SOD1-ALS. Catch up on this example of bold, patient-focused science: jamanetwork.com/journals/jam…
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PrudencioLab retweeted
Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification: biorxiv.org/content/10.64898…
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Loss of progranulin drives the buildup of TMEM106B fibrils in lysosomes, causing their membranes to burst. Risk variants in TMEM106B accelerate this process. @UMich @univmiami @NIH @Stanford ow.ly/tW0b50YTw2W
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PrudencioLab retweeted
Dr. Leonard Petrucelli has joined the Miller School of Medicine as Founding Director of the Neuroscience Institute. Dr. Petrucelli is a visionary scientist and a global leader in neurodegeneration research. His seminal work has uncovered the molecular mechanisms underpinning Alzheimer’s disease, frontotemporal dementia and ALS. His research reveals novel biomarkers and therapeutic targets that will help shape the next generation of treatments, helping to improve the lives of patients facing these devastating diseases.
Welcome, Dr. Petrucelli! Read more: loom.ly/xQNlf4M
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PrudencioLab retweeted
The MBI community gathered today to honor longtime colleague Dr. David Borchelt.
Dr. Gopal Thinakaran, a close collaborator of Borchelt's, opened the First Annual David R. Borchelt Excellence in Neurodegeneration Research Seminar with a talk on BIN1’s role in Alzheimer’s.
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PrudencioLab retweeted
Tracking #ALS early could transform care. Target ALS-backed scientists are developing blood & CSF tests for #CrypticPeptides—potential early biomarkers. Learn more: bit.ly/45vb0wc #ALSResearch #EveryoneLives
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PrudencioLab retweeted
Dr. Leonard Petrucelli is a globally recognized leader in neurodegeneration and our longtime Scientific Advisor. He's been instrumental in shaping #ALSResearch and the very foundation of Target ALS. As he steps down from his role with us, we celebrate his partnership and vision.
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PrudencioLab retweeted
NEW PAPER is out! We measured plasma p-tau217 and Aβ42/40 in 509 patients with the cognitive concerns. Worth a read if you're thinking of using blood-based biomarkers in the outpatient clinic.
doi.org/10.1002/alz.70316
@PiuraYoav1 @MayoClinic @MayoClinicNeuro @mayocliniclabs
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PrudencioLab retweeted
C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7
actaneurocomms.biomedcentral…
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PrudencioLab retweeted
Join us in celebrating our 2024 Cozzarelli Prize Class IV: Biomedical Sciences winning paper, “Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis.” Read more: ow.ly/SyAL50VyXLV
ALT ALT/Caption: 2024 Cozzarelli Prize Winner. Class II Winner: “Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis” Authors: Jakob Theorell, Ruby Harrison, Robyn Williams, et al.
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PrudencioLab retweeted
When #DanDoctoroff was diagnosed with #ALS, he saw an opportunity to make change. See what inspired him to found Target ALS to accelerate the discovery, development, and path to effective treatments.
Take action today: targetals.org/take-action/
#ALSResearch #EveryoneLives
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