Genetics; Computing; Viruses; RNA | The Laboratory for RNA-Based Lifeforms | Molecular Genetics / Donnelly Centre @ UofT 🇨🇦
Toronto
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This is the most consciousness-expanding project I've had the pleasure to contribute to:
🧬 We assembled all 27 million sequencing datasets / 44 petabases, and can search it in hours 🤯 🌎🧬
Next goal: SRA-scale BLAST search in sub 60 seconds
Today we’re excited to freely share an early-version of, perhaps, the world’s most expansive genetics dataset: Logan.
#bioinformatics #petabase #genetics #genomics #openscience
biorxiv.org/content/10.1101/…
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📣 Applications are open for the CIFAR Global Scholars program!
Develop and lead highly interdisciplinary research, expand your network and gain valuable leadership training.
🔗 Learn more and apply by November 4: cifar.ca/next-generation/glo…
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Spanning eight years and over 4,800 experiments, a Hughes Lab global collaboration has concluded with the creation of the Codebook: an enormous database that has illuminated how transcription factors influence human gene regulation:
thedonnellycentre.utoronto.c…
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A history of viral encephalitis is one of the strongest risk factors for developing dementia. With @JacobJacobog02, Yifan Chen, @RNA_Life, and @RyanDhindsa, we refine this link by describing a neuronal cell type that can reactivate HSV-1 in humans 1/n
biorxiv.org/content/10.64898…
ALT https://www.biorxiv.org/content/10.64898/2026.04.29.721769v1
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🧬Ultra fast petabase-scale virus discovery is here! 🚀
In our lab’s newest preprint, Jess explores the biodiversity of Papillomaviruses (PVs) in record time
🧵1/5 👇
🔗: doi.org/10.64898/2026
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🧵4/5 Analyzing this as an 'in-silico ecosystem', we find PV biodiversity hotspots in East Africa and South America, and show that undersampl biomes like Tropical Forests or Mangroves disproportionately yield viral diversity.
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🧬5/5 #Genomics is our shared evolutionary heritage. We re-imagine public sequencing data not as an archive, but a living digital twin of Earth’s Genome.
Infrastructure like 🗻Logan🗻 will help unlock this frontier of genetic diversity 🌎🧬
Preprint🔗: doi.org/10.64898/2026.04.21.…
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Molecular Genetics @ University of Toronto 🇨🇦@UofT🦠 is recruiting an Assistant Professor in #Virology!!
Come build your dream lab!
🔗jobs.utoronto.ca/job/Toronto…
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We are looking for a postdoctoral fellow to work on induced proximity and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration.
nature.com/naturecareers/job…
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#UofT launches $24-million program to create 100 new postdoctoral positions, accelerate independent research ➡️ uoft.me/bZI
ALT An aerial view of King's College Cirlce
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Turn your #PostDoc into a Global Impact. 🌍 Join @UofT/#RNAlab to evolve plastic-degrading enzymes #SynBio. 🧬🔬
SYNTHETIC + MOLECULAR BIOLOGY on MICROPLASTICS - POSTDOCTORAL FELLOW @RNA_Life
University of Toronto
See the full job description on jobRxiv: jobrxiv.org/job/university-o…
#enzymology #microplastics #moleculargenetics #syntheticbiology #Yeastgenetics
#ScienceJobs
jobrxiv.org/job/university-o…
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MetaGraph: A Landmark paper in Petabase-scale Genomics is _finally_ out!
🚀🚀 Congrats Andre + Co. making the world's sequencing data🧬 available in a major achievement for the field. 🚀🚀
After years of research and continuous refinement, we’re thrilled to share that our paper on the MetaGraph framework — enabling Petabase-scale search across sequencing data — has been published today in Nature (nature.com/articles/s41586-0…).
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After years of research and continuous refinement, we’re thrilled to share that our paper on the MetaGraph framework — enabling Petabase-scale search across sequencing data — has been published today in Nature (nature.com/articles/s41586-0…).
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Now online, our work in nucleorhabdoviruses
our latest manuscript with
@humbertodebat
and Ralf Dietzgen is just out in Virology! We identified 47 novel nucleorhabdoviruses in our final chapter of a trilogy exploring the hidden diversity of plant-associated rhabdoviruses sciencedirect.com/science/ar…
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A warm welcome to Donnelly's newest Faculty member, Dr. Khalid Al-Zahrani! Our next news story will talk about his research and his journey; from elementary school trips to Canada Science and Technology Museum, to the first time he did bench work.
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Have you ever wanted to peek behind the curtain of a hackathon? Our most recent article covers everything, from the creation of the winning projects to the private judging deliberations.
Read it here: thedonnellycentre.utoronto.c…
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One year after our initial preprint, we're excited to post a major update to Logan.
At its heart, Logan is the assembly of 27 million samples (50 Pbp) using a 6-day cloud-compute peaking at 2.2M vCPUs. This compresses the SRA 140x compared to raw FASTQs.
github.com/IndexThePlanet/Lo…
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🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵
Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.
doi.org/10.1101/2024.07.30.6…
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🤯 One of the coolest stories I've ever come across showcasing virus-host-superhost interactions. This is a major paradigm in virus pathology that is woefully under-explored. 🍄 #virology #microbiology #fungi
🚨 Fungi + viruses + mammalian lungs? Buckle up! Our new paper in
@natmicrobiol.nature.com
uncovers the story of a deadly fungus and its gnarly viral hitchhiker — and how this duo may change how we diagnose & treat fungal disease 🍄🫁🚨 doi.org/10.1038/s41564-025-0… ⬇️
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