Systems, scaling and architecture for general biological intelligence
San Francisco & Tokyo
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Welcoming Jacob Rinaldi, Head of Scientific Strategy at Radical Numerics.
I'm excited to announce that Jacob Rinaldi has joined @RadicalNumerics as Head of Scientific Strategy!
Jacob was most recently cofounder of Noetik, leading their ML efforts.
Previously he was at Recursion as Head of Oncology, and Genentech, working on cancer vaccines.
At @RadicalNumerics, he'll work to accelerate the application of our models to some of biology’s most important problems, from human genetics and rare disease to cancer vaccines, whole-genome design, and the next generation of AI-enabled therapeutics.
Check out our announcement here:
radicalnumerics.ai/blog/jaco…
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1/5 We pretrained Omnii, a multimodal language model on DNA. Then, we asked it to design a cancer vaccine
In new research, we show how Omnii learned to turn a tumor DNA sequence into a personalized mRNA vaccine design.
Read more here: radicalnumerics.ai/blog/omni…
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4/5 Omnii predicts both for MHC class I and class II, ranks the best targets, then designs an optimized mRNA cassette.
On public benchmarks, Omnii outperformed specialized models on both antigen presentation and immunogenicity prediction, requiring only minimal post-training and no architectural modifications:
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5/5 Moderna’s melanoma cancer vaccine just succeeded in Phase 3. Can we extend this to any cancer, any patient?
We are looking for researchers and partners who want to push this further.
Read the technical post:
radicalnumerics.ai/blog/omni…
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Radical Numerics retweeted
@RadicalNumerics is accelerating, new roles here!
MTS, Experimental Biology
Head of Business Development
Product Lead, Biodefense
Plus *16* AI roles across pre/post training, infra & systems. Come build the largest models in science.
Jobs:
jobs.ashbyhq.com/radical-num…
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Radical Numerics retweeted
Radical Numerics has 16 roles open, from MTS pre/post training, infra & systems, mech interp, to product leads in scientific discovery.
Our team is growing rapidly in SF, and so are the models. We’re pretraining the largest biological AI models ever. Science is the next frontier in AI.
Roles:
radicalnumerics.ai/join-us
- MTS Pretraining
- MTS Post-training
- MTS Infra & systems
- MTS Model interpretability
- MTS ML engineer
- MTS Inference
- MTS AI supercomputing
- Product lead - Discovery
- Product lead - Diagnostics
- Computation biology
- Protein design
- MTS Biosecurity
- Head of Data Acquisition
- MTS AI bio
- Applications engineer
- Marketing associate
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1/ Leaders of OpenAI, Anthropic, & GDM signed a letter urging Congress to mandate DNA synthesis screening.
But chatbots & agents can't read DNA.
So we built Omnii to defend against natural & AI-designed pathogens.
Blog: radicalnumerics.ai/blog/omni…
Letter: screendna.org
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11/ We’re now also pushing toward biodefense infrastructure: surveillance across time, space, and subsequence to map out human risks across metagenomic reads to whole viral genomes (early UI below).
Screening can move from "have we seen it?" to "what could this do?"
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12/ If models become function-aware, our defenses must too. To scale biodefense, we're scaling our team + partnerships.
🌉🌎🗼Join our mission in SF/Tokyo: radicalnumerics.ai/join-us
📝Sign up for early access: radicalnumerics.ai/waitlist?…
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