Exciting to see recent work from the Rullo Lab highlighted in this @BritPharmSoc editorial on the re-emergence of covalent modulation in drug discovery! 🧪
Great to see covalent chemistry continuing to expand what’s possible in chemical biology and immunotherapy.
Very excited to share our group's latest research, published in @NatureComms, titled 'Mimicry of molecular glues using dual covalent chimeras'!
@LabRullo
Check out the full publication here: nature.com/articles/s41467-0…
Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase dlvr.it/T4YBjx
A beautifully written comprehensive review on the use of proximity induced chemistry to generate novel protein therapeutics by @Han_Xiao2016cell.com/cell-chemical-biolo…
Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and Membrane Proteins | ACS Synthetic Biology pubs.acs.org/doi/10.1021/acs…
Excited to return to beautiful Boston this Tuesday and see great colleagues working in covalent drug development and proximity inducing molecules!
covalent-drug-discovery.com/…