SWOG Cancer Research Network runs publicly funded clinical trials that have saved 3 million+ years of life. Founded by the National Cancer Institute in 1956.
United States
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SWOG researchers give #ASCO26 oral presentations on results of 2 GI trials, a testicular cancer study, work on vit D & neuropathy, big-picture results from S1609 DART rare cancers trial, & an AI prediction model in breast cancer! @SWOG ASCO calendar is at swog.org/media/26051.
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"@LungMAP is the most transformative & pivotal trial in the MET Crusaders right now."
Hear MET Crusaders Chair Marcia K. Horn, JD, on 3 current @LungMAP studies for patients with advanced #NSCLC with MET biomarkers. @metcrusaders #lcsm #ClinicalTrials
piped.video/watch?v=H1mxk7qM…
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The S2409 PRISM #ClinicalTrial asks if we can treat extensive stage small cell lung cancer more
effectively by targeting the vulnerabilities of specific molecular subtypes of the disease. #SCLC
#LCSM
PI: @AnneChiangMD @YaleCancer
swog.org/clinical-trials/S24…
@LaurenByersMD @BadiyanMD
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Blog post from SWOG chairs @DrDawnHershman & @PrimoLaraMD:
SWOG Establishes An APP & Nurse Scientist Cmte
Our new cmte recognizes the contributions of APPs & nurse scientists & will help empower more of them to contribute to their full scope of practice.
swog.org/news-events/news/20…
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Front Line post by @SWOG chairs @DrDawnHershman & @PrimoLaraMD:
The Next Era of SWOG Success
We see trials that are more streamlined & decentralized, that integrate community & advocate voices, that ask questions only public-powered research will answer.
swog.org/news-events/news/20…
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Our @SWOG Chairs' blog:
A Team Science Leadership Team
SWOG is all about interdisciplinary collaboration and team science. We think a leadership approach with dual principal investigators who bring complementary skillsets and expertise is a great fit.
swog.org/news-events/news/20…
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Saying Thank You:
@SWOGChair Dr. Charles Blanke's last Front Line post as chair of @SWOG:
"I have been honored to serve as chair of this research group over the last 13 years, and I could not be prouder of what you have accomplished in that time."
swog.org/news-events/news/20…
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15-year results from @SWOG S0016 trial suggest follicular lymphoma is curable. Cure modeling estimates a 42% cure rate among S0016 patients. Relapse rates drop markedly over time.
Study is in Feb 26 @JAMAOnc
@DrJFriedberg @mshadman @WilmotCancer @FredHutch
swog.org/news-events/news/20…
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Registration is open for SWOG's spring group meeting, April 30-May 2, in San Francisco!
Incoming Group Chairs Drs. Primo Lara, Jr., & Dawn Hershman invite SWOG members to bring questions, concerns, & ideas to an interactive Friday plenary.
Learn more at swog.org/news-events/swog-me…
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"Cancer statistics, 2026: Charting a course for a national cancer research agenda," commentary by @PrimoLaraMD & @DrDawnHershman publ w the annual portrait of U.S. #cancer stats in CA: A Cancer Journal for Clinicians, just out! #NCTN #NCORP @theNCI
doi.org/10.3322/caac.70061
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S2213 is a randomized ph 3 to definitively learn role of transplant in pts newly diagnosed w AL #amyloidosis.
@BMTCTN Champion: @adsouza_md
SWOG.org/clinical-trials/S22…
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Treated for muscle invasive bladder cancer and want to keep your bladder? Ask your doctor about #ClinicalTrial S2427 (BRIGHT).
SWOG.org/S2427. 1-800-4-CANCER. #KeepMyBladder #MIBC
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Extensive stage small cell lung cancer can be hard to treat — but study S2409 (the PRISM trial) is looking for better, personalized options. To learn more, visit SWOG.org/S2409 or call 1-800-4-CANCER. #LCSM #SCLC
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S2213 is an #ALamyloidosis #clinicaltrial to determine if Dara-VCD drug treatment or stem cell transplant is better for patients. The study may be an option if your treatment plan could safely include a stem cell transplant. SWOG.org/S2213. Or call 1-800-4- CANCER.
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For all @SWOG early career researchers in #genitourinary cancers:
The Nicholas Vogelzang GU Scholars Program
Includes mentorship and travel support - apply by January 15
thehopefoundation.org/vogelz…
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#ClinicalTrial S2409 (PRISM) asks if it’s possible to personalize treatment for extensive stage small cell lung cancer. It compares standard treatment alone to standard treatment plus a drug matched to the cancer subtype. Learn more: SWOG.org/S2409 or 1-800-4-CANCER.
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Have you had treatment for muscle invasive #BladderCancer? Are you expecting surgery next?
If your scans show no cancer, you may be able to join #ClinicalTrial S2427 (also called BRIGHT).
Visit SWOG.org/S2427 to learn more. Or call 1-800-4-CANCER. #BladderPreservation
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Just activated!
#NCTN S2433 trial is enrolling patients with locally advanced or metastatic #pancreatic ductal
adenocarcinoma without KRAS or BRAF V600E mutations. Randomized to physician’s choice
SOC w/wo panitumumab.
PI: Rachael A. Safyan, MD @fredhutch
swog.org/clinical-trials/S24…
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S2213 is a randomized ph 3 to definitively learn the role of transplant in pts newly diagnosed w AL #amyloidosis.
@Alliance_org Champion: Heather Landau, MD
SWOG.org/clinical-trials/S22…
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Bladder removal surgery can have a big impact on quality of life. Study S2427 (also called BRIGHT) is testing a possible #BladderSparing approach for people with muscle invasive #BladderCancer. To learn more, visit SWOG.org/S2427 or call 1-800-4-CANCER. #MIBC
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If you have extensive stage small cell lung cancer (ES-SCLC) and you haven’t started initial treatment, ask your doctor about study S2409 (PRISM). It tests the cancer for certain features to match patients with treatments. SWOG.org/S2409. 1-800-4-CANCER. #LCSM #SCLC
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Study S2213 asks if a drug combination known as Dara-VCD or stem cell transplant is better for treating AL #amyloidosis. It tests how well the treatments work, and how they affect quality of life. Learn more at SWOG.org/S2213. Or call 1-800-4-CANCER. #clinicaltrial
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Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD:
FDA–AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials
doi.org/10.1158/1078-0432.CC…
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#ClinicalTrial S2409 PRISM randomizes patients with extensive stage small cell lung cancer to durvalumab with or without a drug that’s targeted to their specific #SCLC subtype.
Co-PI: Nan Sethakorn, MD, PhD @LoyolaHealth
swog.org/clinical-trials/S24…
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S2427 BRIGHT trial tests IO + RT as bladder-preserving tx for patients with MIBC who respond to NAT.
PROs track QoL and treatment-related symptomatic toxicities.
Systematic biopsies needed at post-NAT TURBT.
Co-PI: James B. Yu, MD, MHS @DartmouthCancer
swog.org/clinical-trials/S24…
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If you have extensive stage small cell lung cancer (ES-SCLC) and you haven’t finished initial treatment, ask your doctor about study S2409 (PRISM). It tests the cancer for certain features to match patients with treatments. SWOG.org/S2409. 1-800-4-CANCER. #LCSM #SCLC
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Are you getting treatment for muscle invasive bladder cancer? Ask your doctor about S2427 (BRIGHT). It’s a #ClinicalTrial testing whether an immunotherapy drug plus radiation therapy can help patients keep their bladder. SWOG.org/S2427. 1-800-4-CANCER. #MIBC
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What’s the best consolidation tx for patients newly diagnosed with #ALamyloidosis: #StemCellTransplant w melphalan? Or daratumumab + VCD? Trial S2213 also compares minimal residual disease negativity rates.
TM Co-PI: Brian Walker, PhD @IUMedSchool
SWOG.org/clinical-trials/S22…
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Are you starting treatment for #ALAmyloidosis? Ask your doctor about #clinicaltrial S2213. It compares using a drug combination called Dara-VCD vs. stem cell transplant. Learn more at SWOG.org/S2213. Or call 1-800-4-CANCER. #raredisease
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The S2409 PRISM trial biomarker-tests patients with extensive stage small cell #LungCancer during induction treatment and assigns them to 1 of 3 maintenance therapy cohorts based on #SCLC subtype and SLFN11 status. #LCSM
Co-PI: So Yeon Kim, MD @YaleCancer
swog.org/clinical-trials/S24…
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S2427 BRIGHT tests IO + RT as bladder-preserving treatment for patients with #MIBC who respond to NAT.
Focal, non-diffuse carcinoma in situ (CIS) is allowed.
Systematic biopsies needed at post-NAT TURBT.
Co-PI: Daniel A. Hamstra, MD, PhD @BCMCancerCenter
swog.org/clinical-trials/S24…
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AL #amyloidosis trial S2213 compares autologous transplant to Dara-VCD consolidation. Also compares post-consolidation #PatientReportedOutcomes for physical function and other #HRQoL measures.
QoL/PRO Co-PI: @Terri_ParkerMD @YaleCancer
SWOG.org/clinical-trials/S22…
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S2427 (BRIGHT) is a study for people who were treated for muscle invasive #BladderCancer — and the cancer shrunk or can’t be found after treatment. The study asks if a drug plus radiation can help prevent bladder removal. Visit SWOG.org/S2427. Or call 1-800-4-CANCER.
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S2409 (the PRISM trial) is a study for people with extensive stage small cell lung cancer (ES-SCLC). The goal is to match different #SCLC subtypes with the best treatment. Visit SWOG.org/S2409. Or call 1-800-4-CANCER. #LCSM
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Our @SWOGChair blog:
SWOG at SABCS: A Record of Success
The San Antonio Breast Cancer Symposium has been a prime venue for publishing important SWOG research results in breast cancer treatment, symptom management, and prevention. #SABCS25
swog.org/news-events/news/20…
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Enrolling: @SWOG S2213 in newly diagnosed #ALamyloidosis. Daratumumab + VCD induction, then randomization to autologous stem cell transplant or Dara-VCD consolidation. Patients on both arms get dara maintenance.
Co-PI: @SurbhiSidanaMD @StanfordMed
SWOG.org/clinical-trials/S22…
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#Clinicaltrial S2213 asks if a drug combination (called Dara-VCD) or stem cell transplant is better for people with AL #amyloidosis. The trial is for people who haven’t started treatment yet. Learn more at SWOG.org/S2213. Or call 1-800-4-CANCER.
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S2409 PRISM is testing whether it’s feasible to identify each patient’s small cell #LungCancer subtype and use that information to select the best therapy for that patient. #SCLC
Co-PI: Alberto Chiappori, MD @MoffittNews
swog.org/clinical-trials/S24…
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If patients w #MIBC have a clinically sig response to NAT, is cystectomy needed? S2427 BRIGHT trial tests whether pembro + RT can let patients keep their bladder. Systematic biopsies needed at post-NAT TURBT.
Co-PI: Abhishek Tripathi, MD @cityofhope
swog.org/clinical-trials/S24…
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The @theNCI myeloMATCH precision medicine trial portfolio in myeloid cancers is highlighted in numerous presentations at the upcoming #ASH25 meeting. Learn more:
dctd.cancer.gov/about/news-e…
@SWOG @eaonc @ALLIANCE_org @CDNCancerTrials #NCORP
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Our @SWOGChair's blog:
Thank You
Through a year that’s had more than its share of uncertainties, I’m thankful for you, SWOG’s members and supporters, for all you do to care for our patients and advance our research.
swog.org/news-events/news/20…
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Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD:
CAR-T Cells in Solid Tumors: Challenges and Breakthroughs
doi.org/10.1016/j.xcrm.2025.…
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Study S2213 is for people with newly diagnosed #ALAmyloidosis. It compares a combination of immunotherapy and chemo drugs (called Dara-VCD) to stem cell transplant. Learn more at SWOG.org/S2213. Or call 1-800-4-CANCER. Ask about S2213. #raredisease #mmsm
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S2427 BRIGHT trial: In patients with #MIBC, can immunoradiotherapy after response to neoadj therapy (cT0 or cT1) allow for bladder preservation?
Systematic biopsies needed at post-NAT TURBT pre-registration.
Co-PI: @siadaneshmand @uscnorris
swog.org/clinical-trials/S24…
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The S2409 PRISM #ClinicalTrial asks if we can treat extensive stage small cell lung cancer more effectively by targeting the vulnerabilities of specific molecular subtypes of the disease. #SCLC #LCSM
PI: @AnneChiangMD @YaleCancer
swog.org/clinical-trials/S24…
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Our @SWOGChair's blog:
SWOG Is All Over ASH 2025
#ASH25 will feature a sizeable group of posters and presentations reporting on (or responding to) @SWOG research. Here are some highlights.
swog.org/news-events/news/20…
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Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD:
Bispecific Antibodies and Nanotechnology: A Strategic Alliance in Cancer Immunotherapy
doi.org/10.1186/s12943-025-0…
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Our @SWOGChair blog:
This Thanksgiving, It's All About Hope
Thanksgiving is still a couple of weeks out, but high on my list of what I’m thankful for is having the strong support of The Hope Foundation for Cancer Research. @SupportingSWOG
swog.org/news-events/news/20…
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Our @SWOGChair's blog:
Stories of SWOG Accrual Stars
We have many inspiring stories of members and sites going above and beyond to enroll robustly to our trials.
swog.org/news-events/news/20…
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Our #TranslationalMedicine Link of the Week, chosen by @SWOG's @recnac1 & Jimmy Rae, PhD:
WNT Signaling in Cancer: Molecular Mechanisms and Potential Therapies
doi.org/10.1186/s43556-025-0…
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