Partnering with Enterprise AI founders building Companies of Consequence

Menlo Park, CA
Congrats to @zainasgar & the @gimletlabs team on their $300M Series B! 🎉 Every AI product runs on infrastructure. As AI gets more powerful & adoption grows, demand grows exponentially. Gimlet's infrastructure gets more out of existing hardware, serving massive volumes of AI at a fraction of the cost. We're proud to partner with @zainasgar, Michelle Nguyen, @oazizi, @nserrino & James Bartlett. Watch @jai_das sit down with Zain to discuss Gimlet's journey. 🎥
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Robots have been "two years away" for 20 years. That's finally changing. For the first time, the ingredients for commercial-scale physical AI coexist: 🔹 AI models that can reason & act in the physical world 🔹 Hardware costs down an order of magnitude 🔹 Real demand from labor shortages in manufacturing, construction & healthcare @adamdliu, Adrian Kania, Lou Segall & Jake Randall mapped the entire Physical AI landscape across 6 layers. 🔗 sapphireventures.com/blog/ph…
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The gap between durable companies & short-lived hype is widening fast, & when every startup claims to be AI-native, telling the two apart gets a lot harder. @jai_das is heading to @HumanXCo Amsterdam to dig into exactly that. He'll be joined by @vidiborvc (@atomico) & @imthemusic (@RenegadePtnrs) for a panel, The AI Investment Reality Check, moderated by @romaindillet. 📅 Wed 9/23, Main Stage Panel: 15:40–16:00 CEST
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Building strong, meaningful relationships with founders has always been at the root of venture. It's something @aranum hasn't lost sight of in his 14 years at @SapphireVC. His take on AI, what it means to show up for founders, & advice for those building today: 🔗 Read the full feature by @GillianTan for Future Nexus: heyfuturenexus.com/posts/sca…
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The model layer is going plural. Intelligence is becoming cheaper, more abundant, & more interchangeable, & it's the throughline of our Summer 2026 Spotlight Newsletter. Here's what we've been up to this quarter… 🚀 New investments in @harvey, @gimletlabs, @baseten, & @chaidiscovery, + follow-ons in @BlockdaemonHQ, @clay, @cyera_io, @HuntressLabs, & @mercury. 🎉 Congrats to @BioCatch (joining Visa), @contentful (joining salesforce), @dremio (joining SAP), & @MirantisIT (joining IREN) on their next chapters. 💡 Fresh takes on AI x drug development, AI x design, & physical AI's breakthrough moment from @CGao, @rajeevdham & the team. 📢 @CGao on @BloombergTV, @Jai_Das on The Room Podcast, & @aranum in @crunchbase on the open-weight debate, agent trust, & what separates winning AI startups. 🎤 Our partners took the stage at Startup Grind, Web Summit, RAISE Summit, & Step SF. 📩 Read the full issue + subscribe here: linkedin.com/pulse/cheaper-i…
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A big congrats to @SamarAtTemporal & the @temporalio team on the $550M Series E! 👏 We partnered with Temporal at the Series D, when AI agents were becoming more capable, but the infrastructure to make them reliable in production didn't yet exist. Six months later, agents are running payments + customer operations, & Temporal's durable execution layer keeps that work running no matter what breaks. We are proud to continue our partnership with Temporal. Read more about why we first invested: sapphireventures.com/blog/th…
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Congratulations to @kareemamin, @vxanand, & the @clay_gtm team on the $115M funding round! 👏🎉 Over the past year, Clay has built out AI agents that can find ideal customers, monitor buying signals, & run outreach on their own, learning + improving with every use. We're proud to continue to partner with Kareem, Varun, and the entire Clay team as they build the next generation of agentic sales tools. 🔗 clay.com/blog/series-d
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Huge congratulations to @winstonweinberg, @gabepereyra, & the @harvey team on the $550M funding round at a $15.5B valuation! 👏👏👏 Legal is one of the industries where AI is already delivering real, measurable value - work that's language-intensive, expensive, & full of repeatable processes well suited to AI. With 75% of Am Law 100 law firms already using Harvey alongside many of the world’s leading in-house teams, we are thrilled to partner as the team transforms how legal & professional services operate with the power of AI. 🔗 harvey.ai/blog/harvey-raises…
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Why are some of the best, most interesting companies hiding in plain sight? The friction that makes them unattractive to most founders is exactly what makes them defensible. @cgao & @adityareddy97 dig into this discussing: 🔹 Why you should never size a vertical AI market by what companies spend on software. 🔹 Why the most operationally complex markets are actually the best ones to build in (this is your moat against competitors and the frontier labs). 🔹 How vertical AI companies that start with one narrow use case end up owning an entire customer's budget over time.
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When anyone can ship an AI product in a weekend, what actually makes a company defensible? @aranum is taking the stage at @stepconference for a panel on Moats in the Age of Infinite MVPs alongside @marianebekker of @youdotcom, @alysaaco of @BainCapVC, & @anuraggoel of @Render. They’ll cover where durable differentiation comes from - proprietary data, customer-embedded workflows, & security & compliance choices that are harder to replicate than product features. Attending STEP SF? Add it to your agenda: stepsf.com/
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91% of designers now use AI for creative tasks at least weekly, up from 54% just a year ago. @rajeevdham, Jasmine Yang, & Misty Liao spoke with founders, designers, & enterprise practitioners navigating this shift. Here are the 3 areas evolving fastest: 🎨 Graphic & Creative Design: Designs can stay connected to live data & update automatically. 🖼️ Product Design: AI tools are closing the gap between designers and engineers, allowing designs to move directly into code. 🖌️ Workflow Infrastructure: A new layer within the design stack is emerging that captures how a team creates, locking in brand context and process so work doesn’t skip a beat even when the AI models powering it change.
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After 2 decades of enterprise investing, @jai_das has seen enough platform shifts to know the difference between transformation & hype. In his latest FastForward piece, @ron_miller recaps his conversation with Jai from @HumanXCo. They cover how AI is changing the way investors evaluate companies, why big valuations show up in every major tech shift, & what history teaches about backing the winners.
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🧬🔬 It takes 15 years & $2B to bring a new therapy to patients. Clinical development is the longest & most failure-prone stage of that drug lifecycle. And trials are just one layer. Underneath the biology, pharma runs on a massive services industry that AI can now absorb. Over the past 18 months @cgao, @adityareddy97, Jasmine Yang & Misty Liao mapped the AI-native companies rebuilding the drug development stack.
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Public software multiples sit near decade lows on AI disruption fears, while private AI valuations keep hitting record highs. Navigating these realities is both the challenge & opportunity for investors today. @bayareawriter from @crunchbasenews connected with @aranum exploring how he & the Sapphire team are managing this disconnect. The conversation covers what makes enterprise software companies durable, how security & governance are shaping AI buying decisions, why the biggest near-term opportunity in industrial AI is making existing infrastructure intelligent & more.
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