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心不全治療を「変異修復」から「シグナル制御」へ:CRISPR塩基編集による「精密シグナル修飾」戦略[Review] #CRISPR #ABE crisp-bio.blog.jp/archives/4…
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"p38 MAPK inhibition safeguards genome integrity during gene editing of hematopoietic stem and progenitor cells" Vacca R, Della Volpe L [..] Di Micco R. Mol Ther 2026-09-22. doi.org/10.1016/j.ymthe.2026… #CRISPR-Cas9
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"Precision modification of heart failure signaling by CRISPR-Cas9 base editing" (REVIEW) Tadokoro T, Liu N, Olson EN. J Mol Cell Cardiol. 2026-06-10/06-30. doi.org/10.1016/j.yjmcc.2026… #ABE
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"Coevolutionary mining of prokaryotic non-coding elements with a genome language model" David B. Li, Garyk Brixi [..] Michael A. Fischbach, Brian L. Hie. bioRxiv. 2026-09-24 (preprint). doi.org/10.64898/2026.09.22.… Minerva-MLM (Masked Language Modeling) ... In prophages within these genomes, we discover that Unknown Group 27 (UG27) reverse transcriptase systems encode arrays of structurally conserved yet sequence-diverse ncRNAs that template complementary DNA (cDNA) hairpin products.
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"Anthropic’s AI biolab finds ‘CRISPR-like’ DNA in viruses. What’s next?" Heidi Ledford. Nature 2026-09-25. doi.org/10.1038/d41586-026-0… ... The detection effort enlisted roughly 950 AI agents that spent more than 21 hours combing through DNA sequence databases.
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"A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo" Diepstraten ST, Deng Y, Potts MA, Heidersbach A [..] Kelly GL, Fortin JP, Haley B, La Marca JE, Herold MJ [+7]. Sci Adv. 2026-09-18. doi.org/10.1126/sciadv.aec07… ... Partita uses a high-density targeting strategy, deploying 10 sgRNAs per TSS, structured into five gene class-specific sublibraries to maximize transcriptional induction.
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【AI x バイオ】Anthropicの生命科学研究グループが、Claude AIエージェントを介してCRISPRに似た「反復配列を伴う新規酵素」を発見 ~ システムとしての機能解明は進行中 crisp-bio.blog.jp/archives/4… CRISPRの祖先とされるVIPR(Viral Interference Programmable Repeat)論文の筆頭著者も関与
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"PREPRINT: Autonomous AI Agents Discover Reverse Transcriptases with Tandem Repeat Arrays" Peter H. Yoon, Januka S. Athukoralage, Emmanuel Ameisen, Eric Kauderer-Abrams, Nicholas T. Perry, Matthew G. Durrant. alphaXiv. 2026-09-23. alphaxiv.org/abs/2609.ai-age…
Replying to @AnthropicAI
This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.
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CRISP_SCIENCE retweeted
This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists. We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.
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"Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants" Matoba N, McAfee JC [..] Won H, Stein JL [+8]. Nat Neurosci. 2026-09-23. doi.org/10.1038/s41593-026-0… … to test 9,092 non-coding DNA variants linked to human cortical structure in neural progenitor cells. … Regulatory activity was largely driven by Alu ("jumping gene") elements, with younger Alu insertions showing higher regulatory activity, … #CRISPRi
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"Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads" Höijer I [..] Ameur A [+6]. Genome Med. 2026-09-15. doi.org/10.1186/s13073-026-0… PureTarget enables efficient, accurate, and unbiased profiling of genetic mosaicism and DNA methylation at pre-defined genomic regions. Our results show that #CRISPR–Cas9–induced mosaicism is widespread and represents an important factor to consider in genome editing experiments. #zebrafish
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