It's exciting to see how far
#CD40L innovation has progressed since I discovered and characterized CD40L more than 35 years ago at
@Columbia (
bit.ly/4dZJwmt)
Congratulations to the investigators whose Phase 3 data for dapirolizumab in treating systemic lupus erythematosus (
#SLE) was recently published in
@TheLancet. (
bit.ly/4ulFhHX)
Dapirolizumab is a second-generation anti-CD40L monoclonal antibody developed under a license to my Columbia technology. Seeing this pathway advance from my academic discovery to late-stage clinical development is deeply encouraging for patients. I’m grateful to Dr. Bob Glickman who recruited me to Columbia’s Dept of Medicine in 1988 as an assistant professor and to the
@NIH (Physician Scientist, 1985-1990),
@theNCI (RO-1 1992-1995) and the
@ArthritisFdn (Arthritis Investigator 1992-1994) for their support of my career development and lab.
At
@TonixPharma, we're advancing TNX-1500, an investigational third-generation anti-CD40L monoclonal antibody for organ transplant rejection and autoimmune diseases. (
bit.ly/3Qn9RTK)
In collaboration with
@MassGenBrigham, we plan to enroll an investigator-initiated study in kidney transplant in the 2nd half of 2026 pending clearance of the IND by the FDA.
Learn more:
bit.ly/4o7d0DE