Systems neuroscientist, physicist, he|him|his
Fayetteville, AR, USA
Based in United States
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- Following 64
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Had a lively chat about brain criticality with Keith Hengen and Paul Middlebrooks (@pgmid ) on Paul's podcast
braininspired.co/podcast/216…
Explored territory beyond what Keith and I wrote in our recent Neuron review
doi.org/10.1016/j.neuron.202…
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Very proud of this systematic review of all the experimental evidence for criticality in the brain. Wrote it with Keith Hengen (hengenlab.org/). More than 300 papers in the past 2 decades!
cell.com/neuron/fulltext/S08…
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Is criticality a unified set-point of brain function? biorxiv.org/content/10.1101/…
We review the past 20 years of experiments that suggest "yes" and perform a meta-analysis that reconciles many studies that seemed to disagree.
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Q: Why did so many early tests of criticality in awake animals come up negative?
A: Insufficient temporal coarse-graining hides evidence for criticality.
Low-dimensional criticality embedded in high-dimensional awake brain dynamics science.org/doi/10.1126/scia…
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Many brain functions live on low-dimensional manifolds. Criticality optimizes some brain functions. Is criticality low-dimensional? Yes!
Low-dimensional criticality embedded in high-dimensional awake brain dynamics science.org/doi/10.1126/scia…
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There seems to be a paper per day reporting a neural subspace for encoding [fill in the blank with your favorite brain function]. Ever wonder how the brain might find these subspaces without an ideal observer? Our recent paper offers a solution: academic.oup.com/pnasnexus/a…
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We just published a related paper in eLife: elifesciences.org/articles/7…
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Ever wonder what neuronal avalanches and criticality have to do with behavior? We've got one answer to that question in our recent eLife paper:
Scale-free behavioral dynamics directly linked with scale-free cortical dynamics doi.org/10.7554/eLife.79950
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How do motor neural circuits and behavior falter with too much inhibition and with disrupted expression of MeCP2? link.growkudos.com/1gb2dctjb…
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Just wrapped up a super exciting visit to Wash U! Gave an in-person talk for the first time in a long while and had some great discussions of ongoing work on criticality. Thanks to @kbhengen, Larry Snyder, Ralf Wessel, and a bunch of bright students and post docs!
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Very proud of Jingwen's primary PhD work!
Collapse of complexity of brain and body activity due to excessive inhibition and MeCP2 disruption pnas.org/content/118/43/e210…
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Remember Churchland's paper on quenched variability at stimulus onset? Apparently the opposite happens in olfactory bulb. See our recent paper:
doi.org/10.1016/j.isci.2021.…
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NIH-funded postdoc position available in our lab! We really want someone who loves the computational AND experimental facets of very high-dimensional neural systems. APPLY NOW: uasys.wd5.myworkdayjobs.com/…
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Are glia responsible for critical dynamics in neural networks?
Phys. Rev. E 101, 022303 (2020) - Dynamic regulation of resource transport induces criticality in interdependent networks of excitable units journals.aps.org/pre/abstrac…
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Nice perspective paper! Fully agree that reconciling dynamics and function across scales is essential. The criticality hypothesis has much to offer in this effort. A few examples...
sciencedirect.com/science/ar…
jneurosci.org/content/34/50/…
sciencedirect.com/science/ar…
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Cool paper!
The topology of the world shapes the topology of population neural activity.
nature.com/articles/s41593-0…
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