#ARTxSCIENCE2025
Discover the power of
#stemcells through artistic expression and ongoing research. Help up find a winner and vote for your favorite:
lnkd.in/eaQ6bFVU
Gold Standard: the impenetrable barrier of the bladder
The inside lining of the
#bladder, the
#urothelium, forms the tightest barrier in the body, protecting us from urine and bacteria. While the bladder expands and contracts, the urothelium must constantly reorganize itself to maintain the barrier. Our goal is to understand how the barrier is maintained, reorganized and repaired, as the loss of this barrier is a hallmark of
#bladderdiseases such as
#bladderpainsyndrome (BPS) and
#chronicurinarytractinfections (UTIs).
BPS and chronic UTIs cause debilitating bladder pain in a collective 3% of the population. There is no lasting
#cure, the cause is often unknown, and the effect of current treatment is highly variable. Using stem cells, we aim to create a model of the urothelium that fully recapitulates the properties in the native bladder, a “gold standard”. This model will allow us to better understand complex diseases such as BPS and chronic UTIs to pave the way for better treatments.
Led by Dr. Mariaceleste Aragona, our research team has already grown urothelium in a dish from human cells that closely reproduces the morphology of native bladder tissue. Using mice and stem cell models, we are now working on elucidating the complex mechanisms that allow the urothelium to regenerate and stretch to an extraordinary degree while maintaining its barrier. Knowing how the healthy urothelium works will allow us to understand what goes wrong in disease.
Credits:
Oscar Bay Axelsen, PhD Student, @AragonaLab, reNEW Copenhagen
@UCPH_Research @UCPH_health @novonordiskfond