Director Donnelly Centre for Cellular and Biomolecular Research, and Professor at the University of Toronto, Founder AntlerA Therapeutics,
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Stephane Angers retweeted
🔬Join our interdisciplinary research community and help advance discovery, medicine, and human health!
Recent PhD graduates have until Nov. 3 to apply for the Charles H. Best Postdoctoral Fellowship at #UofT's Donnelly Centre, offering $60K for one year: tinyurl.com/4rv5jdxt
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3/4 New mechanism: instead of blocking VEGF, it activates Wnt to repair the blood–retinal barrier. It traces back to our work at @UofT on engineering Wnt-activating antibodies (pubmed.ncbi.nlm.nih.gov/3145…) (pubmed.ncbi.nlm.nih.gov/3410…), then went through AntlerA, EyeBio and Merck.
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4/4 Full year-one results come at #AAO2026 on Oct 10, and the BAROLO (DME) and SUPER TUSCAN (nAMD/RVO) trials are ongoing. Grateful to the trainees, collaborators and patients behind this.
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2/4 Both doses were non-inferior to ranibizumab in best-corrected visual acuity at week 52. The randomized, double-masked trial enrolled 984 patients.
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1/4 Today Merck reported that remigromig (MK-3000, formerly EYE103), a tri-specific Wnt agonist antibody, met its primary endpoint in the pivotal ph. 3 BRUNELLO trial in diabetic macular edema merck.com/news/mercks-remigr…
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Stephane Angers retweeted
$MRK's WNT with positive Ph3 data in DME. This is significant as its the first non-VEGF MONOTHERAPY to show success in retina, after steroids. Nice readthrough for $SRZN as its next up with a VEGF/WNT bispecific.
merck.com/news/mercks-remigr…
Would $MRK be hiring a US sales leader if they knew that Brunello failed? Data is scheduled to be presented next month at AAO, seems very bullish for $SRZN
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Stephane Angers retweeted
As a part of our Summer Undergraduate Research Program, 3rd year U of T student Elizabeth Choi has written her first-ever science communications piece: a highlight of Cindi Morshead's career-long investigation into neural stem cells:
thedonnellycentre.utoronto.c…
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Stephane Angers retweeted
Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work.
We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets.
We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.
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Stephane Angers retweeted
Spanning eight years and over 4,800 experiments, a Hughes Lab global collaboration has concluded with the creation of the Codebook: an enormous database that has illuminated how transcription factors influence human gene regulation:
thedonnellycentre.utoronto.c…
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Stephane Angers retweeted
Over 2,000 pathogens engage with the human species in the ever-evolving battlefield of infection and immune defence. To better understand pathogens, the Taipale Lab has built the eORFeome, a scalable genomics screening platform.
thedonnellycentre.utoronto.c…
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Stephane Angers retweeted
We are proud to announce the nine graduate students being awarded the 2026 Cecil Yip Doctoral Research Awards!
thedonnellycentre.utoronto.c…
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Facinating new Wnt paper published in @PNASNews from the @ClaudioCantu81 group at @liu_universitet explaining how Wnt/β-catenin signaling produces diverse cellular outcomes through TCF7L2/LEF1 binding.
pnas.org/doi/10.1073/pnas.25…
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Stephane Angers retweeted
The Donnelly Centre is hiring a Research and Communications Officer! This role covers the external and internal communications of our community: from news stories and social media, to web page management and event support.
jobs.utoronto.ca/job/Toronto…
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Stephane Angers retweeted
Just amazing to watch deaths from cervical cancer plummet as HPV vaccination coverage increases
thelancet.com/journals/lance…
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Stephane Angers retweeted
When researchers published the full genome sequence of the budding yeast Saccharomyces cerevisiae in 1996, the Boone-Andrews Lab saw the finish line: a complete, global genetic interaction network map.
Read our research retrospective in Donnelly News!
thedonnellycentre.utoronto.c…
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Stephane Angers retweeted
CIHR has recognized Dr. Jack Greenblatt as an outstanding peer reviewer!
Join us in congratulating 19 researchers recognized as outstanding peer reviewers! They stand out for completing additional tasks and providing thoughtful, high-quality peer reviews that help ensure the integrity of health research in Canada.
Learn more: cihr-irsc.gc.ca/e/53994.html…
ALT Outstanding peer reviewers Spring 2026 - with tiled head shots of featured peer reviewers
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Stephane Angers retweeted
Sophie Jovanovic has become the first woman to get drafted in the OHL U18 priority selection to the Brantford Bulldogs — second woman to ever get in drafted in OHL history.
She’s a War For the Roses Champion and MVP. Played alongside Milani and Matt.
Congrats Soph!
#OHLDraft
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Stephane Angers retweeted
Genetic code similarity does not tell the full evolutionary story. A new study by Donnelly researchers in the Blencowe Lab has illuminated a potentially frequent mechanism that generates evolutionary divergence between primate species:
thedonnellycentre.utoronto.c…
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