Structure@Structure_CP

Structure is a monthly publication of @CellPressNews dedicated to research at the cutting edge of #structuralbiology. Tweets are by the Editors.

 Cambridge, MA, USA
cell.com/structure/home
Joined August 2012
1,024 Photos and videos
Online now! Chaperoning by dynamic encasement: Structural basis of linker histone H1 nuclear import dlvr.it/TVf4qn

Chaperoning by dynamic encasement: Structural basis of linker histone H1 nuclear import

Combining cryo-EM and molecular dynamics, Fu et al. show how two importins form an acidic cage around the extremely basic linker histone H1 for nuclear import. Rapidly exchanging contacts shield the...

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Online now! Structures of distinct human acetylcholinesterase tetramer forms in complex with synaptic anchoring proteins dlvr.it/TVbgWl

Structures of distinct human acetylcholinesterase tetramer forms in complex with synaptic anchoring...

Cheung and Karasawa reveal structures of human acetylcholinesterase in different tetrameric forms bound to synaptic anchoring proteins ColQ and PRiMA, found in muscles and the brain, respectively....

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Online now! Molecular basis of metal transport by human ZnT10 dlvr.it/TVbY70

Molecular basis of metal transport by human ZnT10

Mu et al. present cryo-EM structures of human ZnT10 that reveal conformational rearrangements during transport. Mn2+ shifts between distinct binding pockets, whereas Zn2+ stays in one site and...

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Online now! Cryo-electron tomography of functionally validated synapses in human induced neurons dlvr.it/TVY02m

Cryo-electron tomography of functionally validated synapses in human induced neurons

Houcek et al. investigated the function and structure of synapses formed between induced human neurons using electrophysiology and cryo-ET. They compared synapse function between iNs off and on EM...

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Online now! Modulating pseudokinase conformation from the ATP-binding site dlvr.it/TVXwDs

Modulating pseudokinase conformation from the ATP-binding site

Pseudokinases are catalytically inactive but conformationally dynamic. Using hydrogen-deuterium exchange mass spectrometry, Sheetz et al. find that different kinase inhibitors can induce distinct...

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Online now! Structural basis of QX007N neutralizing interleukin-33 for asthma and COPD treatment dlvr.it/TVXp3w
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Online now! AlphaBridge: Tools for the analysis of predicted biomolecular complexes dlvr.it/TVW41D

AlphaBridge: Tools for the analysis of predicted biomolecular complexes

AI tools now predict how biomolecules assemble into complexes, but judging whether a prediction is trustworthy remains difficult. Álvarez-Salmoral et al. present AlphaBridge, a web server and...

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Online now! Structural insights into actin severing and capping by gelsolin dlvr.it/TVNTyG
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Online now! Structural basis of MRP2 interactions with substrate and inhibitor dlvr.it/TVMwWX
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Online now! Dissociation and reassembly of the trimeric ectodomain of a baculoviral fusion protein during low-pH treatment dlvr.it/TVMrM3
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MOSAIC: A flexible, software-agnostic workflow for montage cryo-ET dlvr.it/TVMmqn

MOSAIC: A flexible, software-agnostic workflow for montage cryo-ET

In this issue of Structure, Hylton et al. present MOSAIC, an accessible, acquisition-software-agnostic framework for montage cryo-electron tomography (cryo-ET). By streamlining acquisition and...

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Beyond the thiolate: Discovering natural variation in cytochrome P450 proximal ligation dlvr.it/TVMg30

Beyond the thiolate: Discovering natural variation in cytochrome P450 proximal ligation

In a recent issue of Nature Chemical Biology, Nguy et al. report the discovery of an array of cytochrome P450 enzymes that challenge the long-standing view that P450 hemes must be coordinated by a...

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Meet the author: Stefan Raunser dlvr.it/TVMWZd

Meet the author: Stefan Raunser

In this meet-the-author Q&A, we speak to Stefan Raunser from the Max Planck Institute of Molecular Physiology in Dortmund about his research group’s recent Structure paper entitled “Streamlined...

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Structural insight into sodium-dependent bile acid transport by members of the SLC10 family dlvr.it/TVKvVj

Structural insight into sodium-dependent bile acid transport by members of the SLC10 family

Essential recycling of bile acids is performed by SLC10 transporters ASBT and NTCP. Li et al. present structures of a bacterial SLC10 homolog in multiple conformations. They combine these structures...

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Structural, functional, and mechanistic studies of the bacterial divisome FtsWIQBL in complex with antibiotics dlvr.it/TVKpCK

Structural, functional, and mechanistic studies of the bacterial divisome FtsWIQBL in complex with...

Zhu et al. report cryo-EM structures of the Pseudomonas aeruginosa FtsQBLWI divisome complex. Mutagenesis and in vitro assays show that FtsW elongates glycan chains through distinct donor and...

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Matrix polyamines regulate bidirectional calcium flux through MCU dlvr.it/TVKk1B

Matrix polyamines regulate bidirectional calcium flux through MCU

MCU controls Ca2+ entry into mitochondria, regulating metabolism. Wang, Balderas, Ramos et al. show that polyamines in the mitochondrial matrix bind within the MCU pore. This inhibition is relieved...

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Streamlined montage cryo-electron tomography for exploring the ultrastructure of cells and tissues dlvr.it/TVKbF9

Streamlined montage cryo-electron tomography for exploring the ultrastructure of cells and tissues

Cryo-electron tomography reveals the architecture of cell interiors, but the small field of view of the resulting images limits the appreciable cellular context. Montage tomography solves this, but...

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Structural insight into the role of the periplasmic chaperone Skp in pathogenic Neisseria dlvr.it/TVKR4W

Structural insight into the role of the periplasmic chaperone Skp in pathogenic Neisseria

Dubey et al. report crystal and cryo-EM structures of Neisserial Skp, a periplasmic chaperone involved in outer-membrane protein and surface lipoprotein biogenesis. Unlike trimeric E. coli Skp, NmSkp...

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Last chance to register and save! Today is your final opportunity to secure the early registration discount for @CellPressEvents #CS3Dbiologicalfunction26 Register now and join leading researchers this November. hubs.li/Q04wv4Kc0
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Structural basis for oligoclonal T cell recognition of a shared NRAS cancer neoantigen dlvr.it/TVK0VQ

Structural basis for oligoclonal T cell recognition of a shared NRAS cancer neoantigen

A critical target of tumor-specific T cells is neoantigens arising from mutations in oncoproteins such as NRAS. Sharma et al. used X-ray crystallography and computational modeling to reveal how T...

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