co-founder, Merge Labs co-founder, Forest Neurotech thinking about human + machine intelligence

California, USA
Implanted Brain-Computer Interfaces are getting fast! They're approaching speeds that match unimpaired people typing. But... more electrodes won't be enough to break through the "motor barrier."
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🚀
Today, Pioneer Labs is announcing our first step towards terraforming Mars. 🚀🌼 With equipment that fits in just a single rocket launch, we can convert Martian dirt, water, and air into enough building materials to construct a small city on Mars. To do it, we made the first microbe for Mars. We found the best microbe on Earth and used evolution to teach it how to source all of its nutrients directly from Martian materials. The first astronauts will be greeted with safe shelter already filled with water, oxygen, and rocket fuel for the return journey. This is the first step toward using biology to make Mars a friendly place for life. It lets us live off the land and helps us build the next great frontier. It's the first of five organisms we need to green Mars ⬇️
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Wouldn’t it be nice if we had Ozempic for attention / ADHD?
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🧠🗣️🧠🗣️🧠🗣️
Through the VOICE trial, Terry is using his Neuralink implant to help fine-tune a brain-to-voice interface for himself and others who can’t speak. He trained the algorithm first by miming speech as best he could, then by simply thinking the words and hearing them come out in his own natural voice. Powered by Grok Voice from @SpaceXAI
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Don't miss it!
Whole brain emulation in practice. Transcending biological limits. Implications of brain-computer interfaces and AGI for humanity and consciousness. Our Neuro AI track at upcoming Vision Weekend brings together the people working closest to where mind and machine meet. • @SumnerLN, @merge • Matt Angle, @paradromics • @maxhodak_ , @ScienceCorp_ • Matthew MacDougall, @neuralink • @JoanneZPeng, Amaranth Foundation • @AdamMarblestone @Convergent_FROs Nov 13-15 in San Francisco. Tickets in first reply. Powered by @protocollabs @paradromics @eigenlabs @RetroBio_ FUTO and @d_model_ai
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Sumner L Norman retweeted
We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so. Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training. You can read the full post here: darioamodei.com/post/we-must…
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Sumner L Norman retweeted
Congrats to @mu_anand on Melody, a nonprofit research organization building open-source biosensing tools at the intersection of protein engineering, bioelectronics, and control theory. Explore it here: melodyfro.org/
Hello world! We’re @MelodyFRO. Most wearables don’t go far beyond heart rate and activity. Lab diagnostics paint a deeper picture but don’t read continuously. Melody is building biosensors, devices, and standards to bridge this gap. Hear our story at melodyfro.org
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Wake up babe! New FRO just dropped!
Hello world! We’re @MelodyFRO. Most wearables don’t go far beyond heart rate and activity. Lab diagnostics paint a deeper picture but don’t read continuously. Melody is building biosensors, devices, and standards to bridge this gap. Hear our story at melodyfro.org
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The Nat'l Security Commission on Emerging Biotech (@biotech_gov) just put out a report on US leadership in BCIs. Some of the bottlenecks are very real and in need of centralized/national efforts, e.g. lack of US strategy & coordination, outdated/slow regulation & reimbursement systems. Others like the technical challenges section overfit to a narrow set of problems facing MEAs/DBS/etc. and don't provide vision on the myriad directions that will/are disrupting the field, (some of which are present in the China 5 year plan).
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Forest Neurotech is now Arbor Neuroscience! I couldn't imagine a better scientist and leader than Flip Sabes (CEO, @PhilipSabes) to unlock the mysteries of brain stimulation with Arbor behind him. Congrats to Flip and @WhitneySGriggs. Massive props also to @Convergent_FROs (s/o @AGamick and @AdamMarblestone) for continuing to support the Arbor team as a Focused Research Organization/FRO!
Brain stimulation can work remarkably well for treating brain disease. But we can't predict who it helps, or say why it fails for everyone else. We're building the instruments, data, and models to make neuromodulation predictable. arborneuroscience.org/introd…
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Sumner L Norman retweeted
If we're doing lists of SF people, I prefer heroesofsf.org
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Sumner L Norman retweeted
Until is a very important company. I strongly believe we nearing a significant nonlinearity in lifespan and thriving, but we can't know exactly when it will arrive and people now are sick beyond humanity's ability to help them and will miss it. Being able to gap even just a few years could be the difference between nothing and getting to participate in a future beyond the wildest dreams of human sci-fi. Until isn't The Infinite Party, but, if they are successful, it could be the reason your loved ones make it there.
We’re making progress on one of cryobiology's biggest challenges: finding biocompatible cryoprotectants. Our latest blog post dives into how we built our cryoprotectant discovery engine that scaled up the search from a few dozen candidate molecules to over 250,000, and is already producing hits.
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When I grow up I want to be like Joe. Thanks for the continued support. Great things to come! 🥂
Welcome, @merge ! This is a team of superstars I'm very fond of. @SumnerLN taught me everything I know so far in BCI and the breath of capabilities ultrasound has to communicate with the brain. It’s an honor to work with this group of founders to amplify their efforts. We're all in to do our part to help them reach their dreams. This is a major step for the world, and of course Butterfly. Ultrasound is becoming a key modality in the next wave of neural interfaces, and this team is destined to deliver meaningful advances in science and, in my view, great commercial success. Tonight, at Butterfly’s first BCI Innovation Summit, we’ll bring together Embedded™ partners, neurotech founders, researchers and others in the ecosystem to dive deeper into what’s ahead. Butterfly Embedded is about more than technology. It’s about building a network and a platform for the next wave of innovation. This Summit is a physical representation of that: bringing the community together, live and in one room. Tonight is sold out, but I look forward to sharing some reflections soon. Partnership and collaboration are the way forward. I can’t wait to see the progress we make together! #BCI #neurology #neurotech #semiconductors #ultrasound
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Gm. Congrats to the @merge and @ButterflyNetInc teams!
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Big news in BCIs 🧠 Butterfly Network and @merge are teaming up on a multi-year partnership, bringing Butterfly's Ultrasound-on-Chip™ technology to Merge's mission of building safer, less-invasive neural interfaces. Read the full release: bit.ly/46yoF6n
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Sumner L Norman retweeted
Convergent is one of the few places that can incubate organizations behind transformational science: - @E11BIO -- brain connectomics - @ForestNeurotech -- full brain API that became Merge Labs ($250M investment) - @leanprover -- formal mathematics Now it’s applying that model to AI resilience. Deeply needed.
We're hiring. Think: Sr partner at a venture incubator, but the outputs are Focused Research Organizations Form the thesis, find the founders, build the boards, launch the org AI resilience: bioresilience, cyber-physical systems, epistemic infrastructure, compute governance
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If I had half the qualifications I’d work with Anastasia in a heartbeat Go apply
We're hiring. Think: Sr partner at a venture incubator, but the outputs are Focused Research Organizations Form the thesis, find the founders, build the boards, launch the org AI resilience: bioresilience, cyber-physical systems, epistemic infrastructure, compute governance
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It's hard to overstate how carefully @AdamMarblestone thinks about the trajectory of Neuro and AI. If you're interested in either, check this out.
New episode with @AdamMarblestone, CEO and co-founder of @Convergent_FROs. Adam is an extraordinary catalyst and accelerant for science: he has influenced or routed billions in funding, he helped start significant companies and scientific subfields, and he is the world’s go-to person for neuroscience roadmapping. This year, the NSF launched a $1.5B X-Labs initiative inspired by the FRO model Adam pioneered. Though he started with neuroscience, today he helps organize scientific endeavors across many fields, including AI, math, biology, climate, astrophysics, and more. Adam proposes that fields like neurotech, whole-brain emulation, cryo, and nanotech are severely limited by capital and coordination — not ideas. Connectomics is a clear case. He argues that mapping the brain's full wiring diagram is the approach most poised-to-scale and still extremely neglected. Costs for a molecularly annotated mouse connectome have come down orders of magnitude, from an estimated $10B to $100M–200M, Adam suggests, with a human connectome perhaps costing around $1B–2B. The cost curve of connectomes is similar to transistors and gene sequencing: once it is low enough, we get extraordinary outcomes for humanity. Near-term applications could pay for it: new drug targets for brain disease, insights for AI development, emulations, and even “control knobs” for mood and focus we haven’t identified yet. In this episode, we go deep on many topics in neurotech and beyond: what the brain can do that computers still can't; what neuroscience could teach AI; how you'd actually map a whole mammal brain; how far today's fly-brain simulations really get toward an upload; what it would take to move mind uploading beyond the fringe or science; where brain-computer interfaces go next; nanotech, reversible cryonics, AI doing its own ML research, and even predictive, agent-based economics. I'm very excited to have Adam on the podcast. Hope you enjoy! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:40 What are the grand challenges of neurotech? 00:04:50 What the brain does that computers still can't (on a few bananas a day) 00:14:43 The neuroscience overhang: why brains learn from so little data 00:26:29 How to record and map the brain: DNA "ticker tape," ultrasound, and the unexplored map 00:40:29 Why connectomics is the area most poised to scale 00:47:54 How whole-brain connectomics works, end to end 00:55:27 Simulating the fly brain: how far does it actually get us? 00:57:51 What would it cost to map a mammal's brain? 00:59:55 What will be connectomics' ChatGPT moment? 01:04:35 What a connectome unlocks: disease, drug targets, and the brain's control knobs 01:14:20 Scaling up to the human brain — a faster timeline than expected 01:17:34 Mapping activity, and what the fly connectome has revealed 01:27:55 What you could build with today's connectome 01:35:29 Why uploading may be one of civilization's great cornerstones and transitions 01:42:43 Optimistic visions of a future with uploading 01:49:12 Beyond neurotech: virtual cells, nanotech, and AI-driven science 02:15:29 BCIs today: semi-invasive devices, ultrasound, and what's on the horizon 02:22:44 Why science is capital-and coordination-limited, not idea-limited
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