We study metabolism and everything secreted! Katrin J. Svensson Assistant Professor @StanfordPath Metabolic Core Director @StanfordDRC@svenssonlab.bsky.social
Reporting out today- Phase 1 clinical data, oral Lac-Phe mimetic ENV-308 from @enveda. No safety signals (good) and some changes in other biomarkers including leptin (!)… Phase 2 trials planned in for weight maintenance. @statnewsstatnews.com/2026/08/18/enve…
For decades, we’ve known that the ENPP1 K173Q variant raises type 2 diabetes risk, but not why.
New work from @SongnanW in @li_lingyin's lab, in collaboration with @SvenssonLab, shows that this variant may promote metabolic dysfunction in brown adipose tissue.
Instead of starting with a disease and searching for a drug…we started with a therapy (individual vitamin) and asked: which genetic diseases might they rescue? Essentially a new flavor of nutrigenomics.
Today we share a technical report demonstrating how our drug design engine achieves a step-change in accuracy for predicting biomolecular structures, more than doubling the performance of AlphaFold 3 on key benchmarks and unlocking rational drug design even for examples it has never seen before.
Head to the comments to read our blog.
Congratulations to the 2026 Laureate Award Recipients | We celebrate the highest achievements in endocrinology across research, clinical care, leadership, mentorship, innovation, and service. View the winners: bit.ly/4876pTF#ENDO2026#endocrinology