Applications are open! We have an *incredible* lineup of speakers at the 2027 GRC/GRS on Consciousness, Anesthesia and Evolutionary Biology - January 17-22, 2027 SoCal. Keynotes by Christof Koch, @doristsao (GRC) and @mattlark (GRS). see link below for the prelim program -

This has @TheBorisLab written all over it 😂

📝 Viewpoint: High-dose #psychedelic #clinicaltrials remain poorly masked, which limits isolation of pharmacological effects from expectancy effects. More aggressive active comparators and reduced disclosure may strengthen causal inference. ja.ma/4y5fFlG

Thought-provoking approach to address the massive unblinding and expectation effects that render psychedelic trials impossible to interpret from an efficacy perspective.

@stanfordanes is hiring and we are looking for neuroanesthesiologists in particular! Please see facultypositions.stanford.ed… Competitive pay, great location in the Bay Area (tons of sun and outdoor activities), generous housing assistance programs, & collegial work environment!

Launching scienceofplacebo.org: a living bibliography of placebo and nocebo research. New papers screened & tagged daily by design, population, outcome and findings, with a searchable database (currently about 5,000 papers), an interactive researcher map, events, news and discussion.

Can consciousness be studied in the operating room?

More positive news on psychedelics: psilocybin doses before cancer chemotherapy protects neurons and helps prevent peripheral neuropathy in the experimental model @ScienceMagazine science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…

Psilocybin is already being studied to treat mental health conditions such as anxiety, addiction and PTSD. But can it also prevent nerve pain? A new study offers a tantalizing clue. spklr.io/6017ErWg7

New paper from our @TrPR_Program at @UCSF_BCHSI We compared the effects of psilocin vs. psilocybin. People often don't know, but psilocybin is actually not what makes you trip, it is psilocin, psilocybin's metabolite! Here we found that ... well, they are pretty much the same as one would expect :) Great breakdown below by co-author👇

See our RCT published today @JAMAPsych Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression (TRBD) In TRBD, adjunctive IV ketamine was well tolerated and associated with significant antidepressant effects. @UofTPsych @KBI_UHN @UHN jamanetwork.com/journals/jam…

We have 15 open positions at Astera Neuro! We're hiring experimental and computational neuroscientists and engineers to build a large-scale research effort aimed at understanding consciousness = the brain's internal model of world and self. astera.org/careers/#box=neur… We're looking for: • Experimental Neuroscientists • Computational Neuroscientists • Optical Engineers • Hardware Engineers • Software Engineers • Probe Engineers • and more! I'll share much more about our scientific vision soon. For now: I know we could never have built this in academia. The confluence of talent across different domains, the purposive design of the org structure and open science approach, and the deep, long-term support, all aimed at cracking the brain's internal model, is unprecedented. If you want to understand consciousness, if you sense a huge gap between our internal experience of the world and our scientific understanding of it, if you believe systems neuroscience needs a fundamentally different, collaborative, and scaled up approach, we are building the ideal research environment for you. I've never been more excited in my life. Across Astera Neuro, Astera AI, and Astera Simplex, we're creating a whole new discipline around one question: how does the brain build a world model: a symbolic system that perceives the real world from flickering sensory input streams and can think, plan, and experience? Everyone here is converging on this question from a different direction. The degree of conceptual focus combined with tactical breadth is thrilling. If this sounds like you, come join us. astera.org/careers/#box=neur…

same set and setting for thc and psilocybin. finally someone controlling the variables

ついに。🐹 ハムスターの研究から、冬眠を制御する脳回路をついに特定。自然に冬眠しない哺乳類にも冬眠を誘導できる可能性が浮上。人工冬眠が実現すれば、長期手術・宇宙医療・臓器保存など医療応用の地平が大きく広がる。 science.org/content/article/… #ニューロサイエンス #創薬 #医療イノベーション @ScienceMagazine

Excited to share our new paper in Psychopharmacology: A pilot study comparing high-dose oral Δ9-THC, psilocybin, and placebo under the same set and setting used in psychedelic clinical trials. @JHPsychedelics 🧵 link.springer.com/article/10… 1/14

27 deaths in one toxicology review. QT prolongation averaging 95 msec. Patients are asking about ibogaine — here's the evidence. Free to read: thecarlatreport.com/articles…

We tend to put cannabis and psychedelics into separate boxes, but neurobiology rarely respects our rigid labels. A new pilot study shows that high-dose THC can produce subjective effects that closely mimic psilocybin. If cannabinoid pathways can mirror classic psychedelic responses under specific conditions, the clinical boundaries we have assumed for years need a serious rethink. Read the breakdown: cedclinic.com/high-dose-thc-… #CannabisScience #PsychedelicResearch

A new review suggests that MDMA may help people feel safer, more connected, and more open during psychotherapy. These effects may make it easier to explore difficult experiences and emotions that are often part of trauma recovery. Source: bit.ly/4cwMwaj