Engineering innate immunity // Host-pathogen interactions // Systems Biology // Tuberculosis @MIT @MITDeptOfBE
Boston, MA
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Anyone in my science network have experience with producing soluble TCRs? Better yet affinity maturation of TCRs?
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Anyone in the de novo minibinder design space using their binders as flow cytometry staining reagents? Would love to compare notes if so!
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Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: biorxiv.org/cgi/content/shor…
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/8…
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We're excited! This study supports the concept that there are multiple ways to transfer proteins from the phagosome to the cytosol, and that Mtb specifically takes advantage of this.
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Thanks to our many collaborators at the @ragoninstitute and across the broader community and our funders #tuberculosis
Congrats especially to Owen and Rachel, the two fearless graduate students who led this work -- y'all are the best <3
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Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): biorxiv.org/content/10.1101/…
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We think this work is important because:
1. It helps us think about species differences in new ways
2. It highlights a metabolic gate in Mtb-host interactions
3. It may help resolve long-standing challenges in translating concepts from mouse studies to humans
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