The Cesare Lab@TheCesareLab

We study the mechanisms that maintain genome integrity in human cells. This account is no longer used. Find us on Blue Sky: @thecesarelab.bsky.social

 Sydney, Australia
cmrijeansforgenes.org.au/res…
Joined August 2013
191 Photos and videos
Hello friends - we are now on Blue Sky: @thecesarelab.bsky.social We will continue to post here for the immediate future but expect a complete migration to Blue Sky in coming months. Please do reach out and connect with us there.
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1/Today in @NatureComms “A CPC-shelterin-BTR axis regulates mitotic telomere deprotection”. Here we identify the mechanism that unwinds telomere-loops (t-loops) during mitotic arrest to activate the DNA damage response and signal mitotic stress. nature.com/articles/s41467-0….
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25/We predict this represents non-canonical telomere-dependent tumour suppression activity outside the canonical ageing-dependent proliferative barriers imposed by telomere erosion. Also, we now know the protective functions of the TRF2 basic domain are mitosis specific.
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26/Finally, the data are consistent with t-loops suppressing ATM activation by the chromosome end. We show for the first time that t-loops are opened in a shelterin-dependent manner to signal cellular stress, suggestive of a broader role for these structures in cell biology.
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