Katherine King MDPhD@TheKingLab

Pediatric Infectious Disease physician researching effects of inflammation on hematopoietic stem cells; Advisory Board, Doctors for Change

 Houston, TX
bcm.edu/research/labs/kather…
Joined June 2014
169 Photos and videos
Saying goodbye to Twitter! Follow me to Bluesky!
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Microbes support normal blood production! Authors in this recently published article report on the microbes and microbial metabolites missing from pediatric patients with antibiotic-associated neutropenia. @TheKingLab 👉bit.ly/4fUXyWe
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Katherine King MDPhD retweeted
Mick Milsom@MilsomMick
4 Dec 2024
Confused about possible biomarkers for blood cell aging? Check out this review by Wolfgang Wagner, including exploration of how transferable such markers are between mice and humans - Experimental Hematology exphem.org/article/S0301-472… @ISEHSociety @ELShematology

Biomarkers for aging of blood – how transferable are they between mice and humans?

Mouse models have provided invaluable insights into the aging process due to their genetic similarity to humans, sharing approximately 99% of genes and many comparable gene expression patterns [1,2]....

exphem.org
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Find out what this is about— find me at BlueSky social: @TheKingLab !
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It’s here! Our first actual clinical study re: #microbiota changes in antibiotic-associated neutropenia. onlinelibrary.wiley.com/doi/… @TCHResearchNews @CAGTHouston @BCMFromtheLabs @BCMPedIDFellows

Antibiotic‐associated neutropenia is marked by the depletion of intestinal Lachnospiraceae and...

Prolonged antibiotic exposure causes dangerous hematologic side effects, including neutropenia, in up to 34% of patients. Murine studies established a link between the intestinal microbiota and...

onlinelibrary.wiley.com
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In future work we hope that we can use some of these metabolites to rescue antibiotic- associated neutropenia, making antibiotics safer to use.
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A great collaboration with @baldridge_lab @WUSTL and Ritu Banerjee @VUMCchildren. Congrats to Josie Fernandez Sanchez who spearheaded this work and @ArushanaMak03 HannahYan Jeremy Schraw Rachel Rodgers and many more who contributed to this work @Hemasphere_EHA
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Happy Halloween!!! Reasons to work at a children’s hospital…@CAGTHouston @BCMFromtheLabs
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Also, thanks photo credit Philip Burkhardt
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Thank you @majetilab for visiting us @CAGTHouston @bcmhouston ! You blew us away with your cool technology and insights into AML pathogenesis and future therapies. I neglected to take pictures so sharing some seasonal fun instead.
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Happy to share our work: BST2 facilitates activation of hematopoietic stem cells through ERK signaling - Experimental Hematology exphem.org/article/S0301-472…

BST2 facilitates activation of hematopoietic stem cells through ERK signaling

It is estimated that 400 billion blood and immune cells are made each day in a healthy adult, with these numbers increasing 10-fold in times of stress [1]. Long-term homeostasis of the blood is...

exphem.org
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Another piece of the puzzle in our quest to discover how interferons disrupt HSC quiescence and promote differentiation.
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Thanks to @A_Thatavarty for seeing this story through. @ISEHSociety
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