Join us in Washington, DC on Saturday, October 10 for #DCLung26 - a one-day, comprehensive, multidisciplinary, discussion-based lung cancer CME update! Dr. Misty Shields @drshieldsmd returns to shed light on the increasingly complex SCLC options! medstarhealth.org/dclung

Pray for Indiana. I was literally driving on this street last night. #flood #indianastrong #hoosiers

To say I’m proud of my research assistant Anthony Cuadros in all that he has accomplished in two years in @TheShieldsLab at @IUCancerCenter - is TRULY an understatement. Anthony is a brilliant, thoughtful, kind, collaborative, ambitious, curious, hardworking, and an incredibly effective young man (& avid competitive swimmer) with such a bright future ahead of him. He aspires to be an oncologist and is already an accomplished cancer researcher and advocate, who just graduated high school. He began working in my lab at 16! He has been an author on numerous publications, presented at international conferences, and recently wrote an @ASCO connections article “One More Lap” highlighting his perspective as a young advocate champion, aspiring physician, and researcher for lung cancer. We are SO excited for him as he begins undergrad at @IndianaUniv! We will certainly miss him! #lcsm #sclc #research #thefutureisbright @SclcSMASHERS @SCLCYIForum

Two signs sit prominently on the walls of @theshieldslab as a daily reminder for my team and myself. 1️⃣, for our lab’s culture: to stay humble, to work hard, and to be kind. Translational science is a team sport, and no one person can do it alone. We are better together, encouraging each other along this challenging journey. 2️⃣, for lung cancer awareness: to remember those we have lost, those fighting right now who are SMASHING small cell, their families, and those who may face this disease in the future. These signs 🪧 serve as a daily reminder for our team to never stop searching for much needed answers, to be curious & determined to find truths, to never give up hope, to identify new biomarkers, to have a better understanding of why treatments fail, and to develop new drugs for our patients and their loved ones impacted by small cell lung cancer. To never give up fighting this battle and keep discovering to help find the cure for all. Together, we CAN and WILL do it. 💪 #lcsm #sclc #advocacy #science #researchcurescancer @OTtheScientist @PareshKumaaar @SclcSMASHERS @LUNGevity @IUCancerCenter

Deeply thankful for the mentorship, guidance, career development, and encouragement I have received from the legendary Dr. Larry Einhorn @IUCancerCenter. I am forever grateful & honored to receive his endorsement and critical support that helped to start my research laboratory @TheShieldsLab in 2023, that is focused on advancing biomarkers & novel therapeutic options for small cell lung cancer! For those who may not know, Dr. Einhorn discovered the cure for testicular cancer over 50 years ago at IU and conducted many of the pivotal studies establishing platinum/etoposide in SCLC! #mentorship #shouldersofgiants #cancer #legend @LUNGevity @SclcSMASHERS

Thank you @GO2forLungCancr for highlighting my personal journey and my life mission to help limit the lives changed, impacted, or lost due to small cell lung cancer. Together, we can help limit and ultimately end the suffering caused by #SCLC by: 🧬 Supporting 🔑 research by increasing funding for lung cancer 🫁 Screening all eligible patients with low dose CT chest & implement lung cancer screening programs worldwide 🩸Development of early detection strategies thru liquid biopsies (& more!) 🧪 Support of novel research (🔬 -> 🛌) ⭐️ Encouraging clinical trial participation 🛑 Ending stigma & nihilism 🫂 Spreading awareness & ⬆️support go2.org/blog/dr-misty-shield… @SclcSMASHERS @LUNGevity @SCLCYIForum @IUCancerCenter @TheShieldsLab @triparnasen @LauraAlderMD @ASridharMD @max_diehn @MikeShafiq @PareshKumaaar @OTtheScientist #LCSM

With p53 alterations nearly ubiquitous in SCLC, Dr. @drshieldsmd from @IUCancerCenter discussed how p53 reactivators and MCL-1 inhibitors may offer a rational combination approach. #DAVALung

Relapse in #SCLC is unfortunately too common. Historically, chemotherapy-free intervals (CTFI) following last platinum exposure to relapse have been utilized to help prognosticate outcomes for patients with ES-SCLC. Turns out, not all relapse in SCLC is the same... In this publication, led by Dr. Paresh Kumar, we demonstrate how radiographic patterns of progression impact outcomes for patients with ES-SCLC receiving chemoIO. Patients w/ oligoprogression (OP) after chemoIO: ⭐️Improved overall survival (17.5 vs 8.6 mo) ⭐️Survival post-progression (11.1 vs 2.3 mo) ⭐️More likely to be female (75% vs 25%) Patients w/ multi-focal POD (non-OP) after chemoIO: ❗️More likely to be hospitalized (66.7% vs 29.8%) ❗️Receive fewer subsequent therapies (58% vs 89%) ❗️Transition to hospice within 3 mo (50% vs 6.4%) 🚨 Importantly, CTFI failed to predict post-progression OS in our cohort (HR 1.62). Translational biomarker 🧬analysis from liquid biopsies highlighted that patients with non-OP are enriched in hypermethylation of CpGs in HOXA5, a key tumor suppressor and transcription factor that typically binds to the promoter of p53 to induce apoptosis.☠️ 📣Call to action: Progression patterns in SCLC matter. Patients with non-OP should be prioritized for trials, as they are at higher risk for fewer treatment options, hospitalization, and mortality. @ClinicalLung @PareshKumaaar @MyaPrecisionG @SclcSMASHERS @TheShieldsLab @YoungLungCancer @Lung_Cancers @OncoAlert @OncBrothers @oncodaily @StephenVLiu @lungoncdoc @LauraAlderMD @RManochakian @sitcancer @OncLive #LCSM

Proud of my amazing team of dedicated residents, medical students, pharmacists, and fellows with four posters presented at @ASCO this year! A blessing to have such an incredibly hardworking, passionate, supportive, collegial, brilliant, and caring team who are all focused on changing outcomes for patients impacted by small cell lung cancer! @TheShieldsLab @IUCancerCenter @IUMedSchool @IUpulm @IUIntMed @IUHemOnc @PareshKumaaar @AAlfonsoMD @brookmarie99 @OncLive #SCLC #LCSM #teamwork #research

Honored to speak today with @IUAA at @LucasOilStadium sharing about my laboratory’s research @TheShieldsLab in small cell lung cancer as one of the 350+ cancer researchers at @IUCancerCenter #researchcurescancer @IUBloomington @IUMedSchool @IUIndianapolis @IUgradschool @IUHemOnc @IUIntMed

BLESSED BEYOND MEASURE for the opportunity of a LIFETIME to speak at the 2026 @ASCO lung orals session as the discussant on FOUR impactful abstracts focused on novel therapeutic strategies for small cell lung cancer! These trials represent HOPE through progress, dedicated research, discovery, curiosity, and serve as new/future options for our Small Cell SMASHERS & their loved ones. Deeply grateful for this opportunity to highlight the key aspects of each study and how we can use this knowledge to help change/improve the way we treat, care for, and support our patients all over the world impacted by small cell lung cancer. Thank you to every patient, SMASHER, and loved ones who dedicated their lives to be parts of these studies. Because of your courage, altruism, and selflessness, we are one more step closer to limiting loss from small cell lung cancer. #ASCO2026 #researchcurescancer #lcsm #trials #research @SclcSMASHERS @ConquerCancerFd @IUCancerCenter @LUNGevity @TheShieldsLab @LauraAlderMD @FordePatrick @LaurenByersMD @g_mountzios

What a wonderful moment!

“What does your cancer research lab @TheShieldsLab at @IUCancerCenter study?” We focus exclusively on identifying new biomarkers, targets, and drugs for small cell lung cancer. Our goal is to help patients impacted by lung cancer live longer, fuller, and happier lives, as a result of our research. #research #supportresearch #lcsm #MDPhD #science

Count down to #ASCO2026! ⏰ Looking forward to all the EXCITING updates ahead for our Small Cell SMASHERS and families impacted by small cell lung cancer. Every new discovery brings renewed hope, sharper science, and creates momentum toward better treatments and happier, healthier, and fuller lives. Grateful for all of the clinicians, researchers, nurses, pharmacists, students, companies, and advocates who push progress in SCLC forward every day. 🫁🥹❤️ @ASCO @ConquerCancerFd @ASCOPost @ASCOPres @LUNGevity @SclcSMASHERS @lungoncdoc @OncodailyLung @LungCAN @Lung_Cancers @OncBrothers @TheShieldsLab @TheWRP4LC @Cracking_Cancer @YoungLungCancer @OncogeneCancer @OncoAlert @FoundationGo2 @chrisdraft @StephenVLiu @Latinamd @LaurenByersMD @triparnasen @sands_jacob @LauraAlderMD @cancerGRACE @SCLCUnicorn @SCLCYIForum #ASCO26 #meded

Lung Cancer Voices of Hope is a new podcast from LUNGevity that brings together people living with #lungcancer and experts in lung cancer care to share insights, perspectives, and most of all, support. Start listening today! brnw.ch/21x1RW7 @drshieldsmd @sclcsmashers

@DrShieldsMD at #TexasLung26: "Dawn of a revolution in therapy for SCLC". This year's slide shows the progress we've made. Look forward to @TheShieldsLab moving the needle for this aggressive cancer! @TLCconference

I am deeply honored beyond words to be invited as a discussant for the oral abstracts in lung cancer at #ASCO26. It is a privilege to serve this wonderful community and to highlight progress that brings hope to our patients and their loved ones impacted by lung cancer. #goodnessofgod #blessedbeyondmeasure #LCSM @IUCancerCenter @SclcSMASHERS @TheShieldsLab @ASCO @ConquerCancerFd

Why do you want to study small cell lung cancer? For my Dad. For our patients to live longer. For one more lap. To help find cures. To spread hope. #lcsm #research #oncology #sclc @SclcSMASHERS @LUNGevity @TheShieldsLab @IUCancerCenter

Never underestimate the power of one. One patient can change everything. Discovery lies in the outliers. Ask why. Follow the science. 🧪🧬🔬 #research #medtwitter #sclc #lcsm #biomarkers #precisionmedicine @SclcSMASHERS @TheShieldsLab @IUCancerCenter @IUMedSchool @MoffittNews @ktgminton @hilalozakinci @OTtheScientist @PareshKumaaar @MyaPrecisionG @MCT_AACR @AACR aacrjournals.org/mct/article…

How are brain metastases managed in #smallcell #lungcancer? On 3/20 @LauraAlderMD (@DukeMedicine) will join @drshieldsmd (@TheShieldsLab) and Ann Fish-Steagall, RN, BSN (@LUNGevity) for the the monthly Small Cell SMASHERS YouTube Live. YouTube.com/lungevityfoundat… #SCLC #lcsm