Trends in Biotechnology@TrendsinBiotech

Trends in Biotechnology publishes reviews and original research in biobased technology. Published by @cellpressnews; tweets by the editor Matt Pavlovich.

 Cambridge, MA, USA
cell.com/trends/biotechnolog…
Joined June 2012
556 Photos and videos
Our September issue is online! cell.com/trends/biotechnolog… Read about gas-grown biomass, microbial cell factories, CAR-NK therapy, biosensors in liquid biopsy, genome editing in plants, light-inducible gene therapy, liver organoid biofabrication, base editor remodeling, and more.
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Online now: Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of indole-derived compounds dlvr.it/TVhmx7

Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of indole-derived compounds

Sun et al. engineer Saccharomyces cerevisiae to convert glucose into indole-3-acetonitrile and multiple downstream tryptophan-derived indole compounds. By combining cytochrome P450 engineering with...

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Online now: Advancing mRNA therapeutics from design to delivery dlvr.it/TVgxZv

Advancing mRNA therapeutics from design to delivery

mRNA therapeutics have emerged as a transformative platform for vaccines and protein replacement therapies, yet their broader clinical and commercial translation remains constrained by challenges in...

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Online now: Engineering Pseudomonas putida KT2440 for open-loop upcycling of mixed plastics dlvr.it/TVf4hx

Engineering Pseudomonas putida KT2440 for open-loop upcycling of mixed plastics

We report a single, fully genome-engineered Pseudomonas putida ETAB-HB V4 strain for valorizing complex plastic-derived feedstocks into (R)-3-hydroxybutyrate. The results support open-loop recycling...

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Online now: Nanozymes and the restoration of immune tolerance in autoimmune diseases dlvr.it/TVdFk5

Nanozymes and the restoration of immune tolerance in autoimmune diseases

Autoimmune diseases (ADs) are characterized by persistent immune dysregulation and oxidative imbalance, yet current therapies largely rely on broad immunosuppression that rarely restores durable...

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Online now: Plasmid copy number control offers a versatile tool in synthetic biology applications dlvr.it/TVcPqQ

Plasmid copy number control offers a versatile tool in synthetic biology applications

Plasmids are central tools in biotechnology, yet their copy number is often treated as fixed. This study shows that plasmid copy number can be dynamically controlled to tune gene expression, growth,...

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Online now: Asking pragmatic and RAD questions about organoid intelligence dlvr.it/TVbXyq

Asking pragmatic and RAD questions about organoid intelligence

Debates about whether organoid intelligence systems are conscious, or can suffer, often stall on the question of what these organoid entities and systems are. A reflexive, anticipatory, and deliber...

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Online now: Designing artificial cofactors and their enzymes together dlvr.it/TVZjMv

Designing artificial cofactors and their enzymes together

When replacing expensive redox cofactors, making biomimetic cofactors with desirable thermostability and redox properties is only half of the equation; enzymes must also be able to use them. Ji and...

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Online now: Why cell agriculture struggles with meat and opportunities for non-food tissues dlvr.it/TVZ0Rx

Why cell agriculture struggles with meat and opportunities for non-food tissues

Cellular agriculture uses cells to produce animal-derived products without raising whole animals. However, scaling cultivated meat into affordable, structured food remains difficult. In this opinion,...

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Online now: Liquid biopsy in glioblastoma: emerging technologies and translational opportunities dlvr.it/TVYSZx

Liquid biopsy in glioblastoma: emerging technologies and translational opportunities

Glioblastoma remains highly aggressive, with limited treatment response and poor prognosis. Tissue biopsy (TB) is invasive and fail to capture tumor heterogeneity or temporal dynamics. Liquid biopsy...

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We strongly agree: therapeutics are an important part of biotech, but so are chemical and materials synthesis, food, energy, resource conservation, and so much more.
Sebastian S. Cocioba🪄🌷@ATinyGreenCell
Sep 17
I absolutely love that when someone says life sciences whay they really mean is drug discovery. THERE IS MORE TO BIOTECH THAN PHARMA FFS.
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Online now: Enzyme evolution and metabolic engineering for 5-aminolevulinic acid production dlvr.it/TVXnwp

Enzyme evolution and metabolic engineering for 5-aminolevulinic acid production

5-Aminolevulinic acid (5-ALA), a nonproteinogenic amino acid, has emerged as a versatile metabolite for applications in health, agriculture, and sustainability. Advances in ALA synthase engineering...

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Trends in Biotechnology retweeted
Trends in Biochemical Sciences@TrendsBiochem
Sep 17
TIBS and @TrendsChemistry want to hear from you - we’re seeking Reviews for our joint special issue on #Biogeochemistry! Find more information and submit your proposal: cell.com/cp/special-issues/c… #Geochemistry #Biochemistry #Chemistry #CallForPapers
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Online now: Cross-target and cell-preferential CRISPR-Cas9 inhibition with carbohydrate-tagged oligonucleotides dlvr.it/TVWx7w
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Online now: DipTRANS: an improved method for in planta transformation and genome engineering in Nicotiana benthamiana dlvr.it/TVW3tn

DipTRANS: an improved method for in planta transformation and genome engineering in Nicotiana...

Qi et al. develop DipTRANS (Direct in planta Transformation), a soil-based transformation platform that entirely bypasses plant tissue culture. By integrating developmental regulator-induced regene...

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Online now: A combinatorial construct library enables an expanded expression range of secreted therapeutic proteins by probiotic yeast dlvr.it/TVV8rr
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Online now: Engineering biosensors to enhance monoterpene indole alkaloid production in yeast dlvr.it/TVTFn1

Engineering biosensors to enhance monoterpene indole alkaloid production in yeast

Holtz et al. repurpose RamR, a bacterial protein implicated in antibiotic resistance, into biosensors for plant-derived anticancer, antimalarial, and analgesic alkaloids. In yeast, these sensors...

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Online now: An electrified future with microbial electrochemical technologies: how to realize the dream? dlvr.it/TVSVCz

An electrified future with microbial electrochemical technologies: how to realize the dream?

Microbial electrochemical technologies (METs) are emerging with innovative applications in various fields by harnessing the combined action of electrodes and microbes. What if METs could be the key...

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Online now: Volumetric 3D printing of microalgae-based engineered living materials dlvr.it/TVRwDt

Volumetric 3D printing of microalgae-based engineered living materials

In their work, Windisch et al. demonstrate the successful adaptation of volumetric 3D printing to photosynthetically active green microalgae-based engineered living materials (ELMs), addressing key...

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Trends in Biotechnology retweeted
Wei Gao@WeiGaoLab
Sep 11
Excited to share our new work in @Device_CP @CellPressNews : a wearable sweat sensor for multiplex monitoring of female hormones estradiol + progesterone, using two redox-distinct aptamer systems on a single printed electrode. @Caltech cell.com/device/fulltext/S26… Cheers to the team!
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Online now: A logic-gated synthetic circuit coupled with microenvironmental reprogramming overcomes immune exclusion in antigen-poor chondrosarcoma dlvr.it/TVRCBP

A logic-gated synthetic circuit coupled with microenvironmental reprogramming overcomes immune...

Suh et al. program antigen-poor chondrosarcoma cells to become visible to T cells. Their genetic circuit switches on a T cell-recruiting surface protein only when two chondrosarcoma-selective...

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