ITMAT@UPENN_ITMAT

ITMAT was launched formally in January 2005; the first Institute of Translational Medicine And Therapeutics in the world.

 Philadelphia, PA
Joined April 2024
145 Photos and videos
Establishing #Fruitfly model to discern #MolecularMechanisms of #Sleep & #CircadianClock related #MetabolicDysfunction for developing #TherapeuticOpportunities elifesciences.org/articles/1… @weljielab #Metabolomics #TranslationalScience

Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.

elifesciences.org
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#TherapeuticPotential of combining #IRE1α and #KRAS inhibition in #PancreaticDuctalAdenocarcinoma doi.org/10.1073/pnas.2612523… #PDAC #Hypoxia #Oncology #LiverCancer #SolidTumor #TranslationalScience

IRE1α–XBP1s signaling links lipid homeostasis to hypoxic maladaptation and KRAS inhibitor responses...

Pancreatic ductal adenocarcinoma (PDAC) is among the most hypoxic human tumors. Because fatty acid (FA) desaturation is oxygen-dependent, hypoxia c...

pnas.org
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Importance of a life course approach to #Prevention and intervention that addresses #RiskFactors for #FunctionalImpairment in younger individuals and those in early middle age doi.org/10.1371/journal.pone… #HealthyAging #PreventiveHealth #TranslationalScience

Trends in trajectories and incidence of functional impairment in middle-aged Americans

The prevalence of functional impairment (i.e., difficulty performing daily activities such as bathing and dressing) has increased among middle-aged Americans, but longitudinal data are lacking. The...

journals.plos.org
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Improving the safety and efficiency of adenine base-editing therapies nature.com/articles/s41551-0… @kiranmusunuru @AhrensNicklas #CRISPR #Phenylketonuria #PseudoxanthomaElasticum #HereditaryTyrosinemia #TranslationalScience

Improved specificity and efficiency of in vivo adenine base editing therapies with hybrid guide RNAs

Nature Biomedical Engineering - Hybrid gRNAs significantly increase targeted editing in the liver while simultaneously reducing unwanted bystander editing in humanized mouse models.

nature.com
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Characterizing #Inflammation induced #Metabolomics changes in mouse models of #ImmuneActivation and in tissue culture #Macrophages doi.org/10.1016/j.jbc.2026.1… @Caroline_Bartma @EJohnWherry #ImmuneResponse #TranslationalScience
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Building an understanding on the physical & chemical roles of membranes to bind #Coagulation proteins & to affect their function doi.org/10.1073/pnas.2622255… #FactorV #FactorVIII #StructuralBiology #MembraneBiology #CryoEM #TranslationalScience

Structural basis for membrane binding by coagulation factors V and VIII and their specificity for...

Phosphatidylserine on the surface of activated cells serves as a signal for coagulation factor binding and the membrane-dependent assembly of enzym...

pnas.org
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Single #lncRNA integrates #Inflammatory and #Metabolic signals to regulate #CardiovascularHomeostasis doi.org/10.1016/j.celrep.202… @FitzGerald__Lab #PACERR #GeneRegulation #Cyclooxygenase #TranslationalScience
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Elucidating pharmacological targets of Sodium-glucose cotransporter 2 inhibitors (SG LT2i) science.org/doi/10.1126/scie… @AranyLab #HeartFailure #SGLT2 #CardiacMetabolism #TranslationalScience

SGLT2 inhibitors activate pantothenate kinase in the human heart

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantot...

science.org
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#SpatialNT-Seq to spatially co-map newly synthesized and pre-existing #RNA in intact tissues nature.com/articles/s41593-0… @hao_wu_7

Spatial mapping of RNA turnover kinetics in the mouse brain

Nature Neuroscience - The authors developed spatial NT-seq to map the landscape of RNA turnover and stability regulation in the mouse brain, identifying the dentate gyrus as a turnover hotspot and...

nature.com
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Dissecting mechanistic leads to map #Craniofacial & #Cardiovascular defects in #CongenitalDisorders including #Kleefstra syndrome doi.org/10.1172/JCI205970 @JonEpsteinLab #RareDisease #TranslationalScience
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Novel #MouseModel allows study of #Senolytic mechanisms linked to specific cell types doi.org/10.1016/j.jcmgh.2026… @kaestner_klaus #LiverDisease #AgingResearch #CellularSenescence #TranslationalScience
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Defining therapeutic options to target advanced disease refractory to conventional #CARTCell therapy through nonactivated #CARTCell as distinct cell biological state doi.org/10.1182/blood.202603… @carlhjune #CARTcelltherapy #CellTherapy #TranslationalScience

Single-day nonactivated IL-18–armed CAR T cells establish a durable, stemlike state with enhanced...

Key PointsNonactivated CART19-IL-18 cells generated within 24 hours retain a naïve-like, exhaustion-resistant phenotype with enhanced potency.IL-18 enhance

ashpublications.org
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Characterizing #Immunoregulatory roles of #Itch inducing neurons in #Psoriasis doi.org/10.1016/j.jid.2026.0… #Pruritus #GammaDeltaTCells #Neuroimmunology #Immunology #SensoryNeurons #TranslationalScience
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Towards safer #Therapeutics: Structured semantic data enhances #ToxicityPrediction of molecule substructures doi.org/10.1016/j.isci.2026.… @JDRomano2 #MachineLearning #SemanticModel #TranslationalScience
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Magnitude of time-of-day differences in #GeneExpression vary considerably between individuals journals.sagepub.com/doi/10.… #Circadian #BiologicalRhythm #TranslationalScience

Defining and Detecting Global Transcriptional Amplitude in Circadian Gene Expression - Michael M....

Many genes exhibit circadian rhythms in expression. The amplitude of oscillation, both in core clock and circadian output genes, may differ from person to perso...

journals.sagepub.com
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#RetinalAge emerges as #Biomarker for #EarlyDetection of #CognitiveDecline doi.org/10.1016/j.xops.2026.… #BiologicalAge #DeepLearning #TranslationalScience
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Foundation to understand #BiologicalMechanism of #CentromereEvolution and its implications for #Chromosome segregation fidelity and #HumanDisease doi.org/10.1038/s41586-026-1… @glennis_logsdon #Centromere #TranslationalScience

A global view of human centromere variation and evolution

Nature - Complete sequencing of more than 2,000 centromeres from diverse humans reveals structures and elevated mutation rates that shape the evolution of these critically important regions.

nature.com
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Plasticity in #CellCellCommunication may be central for how cell fate is robustly established in complex patterned tissues doi.org/10.1038/s41588-026-0… @KSusztak #SingleCellRNASequencing #SpatialTranscriptomics #KidneyDevelopment #TranslationalScience

Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding...

Nature Genetics - The spatial organization of human kidney development is explored using single-cell RNA sequencing and spatial transcriptomics, highlighting the crucial role of microenvironmental...

nature.com
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Telomere length within normal human range represents critical determinant of hematopoietic reserve capacity under proliferative stress doi.org/10.1016/j.jbc.2026.1… #TelomereBiologyDisorders #DyskeratosisCongenita #HoyeraalHreidarssonSyndrome
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Uncovering new #TherapeuticOpportunities to reduce #Dyslipidemia and susceptibility to #LiverDisease by studying variants of glucokinase regulatory protein doi.org/10.1016/j.molmet.202… @PaulTitchenell #GKRP #CholesterolMetabolism #TranslationalScience
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