Protein Design and Synthetic Biology research lab in the School of Chemistry, University of Bristol and the Center for Protein Design, University of Copenhagen.
Bristol, UK & Copenhagen, DK
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🚀We’re excited to announce fully funded PhD positions in de novo protein design at the Novo Nordisk Foundation Center for Protein Design (CPD), University of Copenhagen.🧬✨
Start: September 2026
Apply by 4 March 2026
candidate.hr-manager.net/App…
Please share!
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From sequence–structure analysis of natural 3HBs, we derived polar layer packing rules + charge patterning to design 2x ABN heterotrimer peptides, seeding hyperstable, monomeric proteins in clockwise & anticlockwise topologies by precisely controlling helix–helix interfaces.
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New paper from our group combines rational and computational design to build antiparallel 3-helix bundle (3HB) assemblies and single-chain proteins with defined topology and tunable thermal stability. 🧩pubs.rsc.org/en/Content/Arti…
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As part of this new chapter, our research group will expand its activities to Copenhagen, forming a joint presence across both sites. We will continue to operate in Bristol, while establishing new lines of research and collaborations within the CPD.
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We are thrilled to announce that Professor Dek Woolfson has been appointed Director of the Novo Nordisk Foundation Centre for Protein Design (CPD) at the University of Copenhagen.
novonordiskfonden.dk/en/news…
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🚛🧬 New paper on rXiv! We reveal how cargo binding activates kinesin-1 by dislocating the TPR shoulder — a key structural switch that unlocks motor movement.
Happy reading!
🔗biorxiv.org/content/10.1101/…
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Another publication in collaboration with Tom Oliver's group in @BristolChem We harness de novo α-helical barrels as "molecular flasks" to bind and orient small molecules in aqueous solution. Using FRET and photodimerization, we showcase the potential for templating new chemistry
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Read more here: pubs.rsc.org/en/content/arti…
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🔬 New paper from our lab! We explored peptide exchange dynamics in de novo coiled-coil assemblies, from dimers to heptamers, revealing both faithful and promiscuous behaviours. Using a new fluorescence-based assay, we uncovered design strategies to enhance orthogonality.
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Exciting opportunity to join the University of Bristol as a BBSRC-funded Research Associate (4 years) working between us and @MarkDodding's lab. The post is on designing de novo peptides and proteins using both rational design and computational design and protein biochemistry.
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Excited to share our latest designed A3B3 α-helical barrels, revealing how subtle the heptad register shift impact helix orientation. Well done to @ChubbJoel @KIAlbanese and team @WakeChemistry @Macquarie_Uni Read more here biorxiv.org/content/10.1101/…
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Our new work with @ChrisWellsWood introduces the Protein Design Archive (PDA) – a comprehensive database of designed proteins. Explore 40 years of advances in design, with insights on trends, challenges, and new opportunities! 🧬💡
Freely available here: pragmaticproteindesign.bio.e…
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Last week we said (a very difficult) goodbye to Dr @KIAlbanese. 3 years has passed since she joined us, she’s been such an inspirational leader and mentor. As Katherine starts her independent career @WakeChemistry, we cheer her on every step of the way. Go shine, Katherine!!💖🌟
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New preprint out in bioRxiv, in collaboration with @MarkDodding . Check out Jess's work on engineering an allosteric switch into kinesin-1 motors through de novo protein design. Congrats to Jess and the team! biorxiv.org/content/10.1101/…
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We have a funded PhD position starting Sept 2024 on the
@SWBio_DTP
'Targeting subcellular protein and processes with designed peptides'. This project is co-supervised by
@MarkDodding
@PaulVerkade
at Bristol. Direct link below..
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Check out our latest collaborative work with the Hebrew University of Jerusalem, on understanding the molecular mechanism of oligomerisation of a peptide representing the STIL coiled-coil domain. @freddie__martin @HebrewU
mdpi.com/1422-0067/24/19/146…
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Last week Dek and Xiyue @SeraphimLeng presented at the 8th Foldamers symposium in Munich, engaged with great science and had lots of interesting discussions with the wider foldamer community! Many thanks to the organising committee @ak_huc and @LMU_Muenchen for the conference✈️
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📢 New paper out in @NatureChemistry, well done to Alex, Andrey and the team! Read more to see the de novo designed proteins that form membraneless organelles in E. coli nature.com/articles/s41557-0…
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Friday submission day - Katherine and Rokas enjoying their celebratory cold beers at Bristol’s iconic suspension bridge, kudos to them both for their hard work!! Check it out
biorxiv.org/content/10.1101/…
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