Husband. Parent. Dr sc @ETH. Bioinformagician. Father of @PacBio HiFi. C++ Purist. Geek. Digital Artist. Electronic music. Speaks in memes. Opinions are my own!

Germany
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After 12 years at @PacBio, I'm proud to announce that I've been promoted to Fellow - moving back to a full-time individual contributor role to work with the great folks across the company! I'm excited to finally have the space to explore the hard problems and even crazier ideas
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Armin Töpfer retweeted
how it feels to use unlimited opus 5.5 before anthropic nerfs it in 2 days
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There's no way you can exhaust Claude MAX with Opus 5.5 without doing really stupid things.
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Please don't nerf Opus 5.5!
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Just ran out of 67% weekly limit left in one hour. Something is broken. @thsottiaux 01a08708-e18f-74f0-8af0-258024bcd427
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I'll create the Half-Life 2 of bioinformatics.
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Been running Ox-Alpha on a task for more than 12 hours so far that every bioinformatician told me can't be done efficiently. We'll see, we'll see.
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Ox-Alpha, inferior GPU kernel developer compared to Fable.
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Two days ago, I wiped my ~/.claude dir and couldn't be happier with Fable's results @bcherny
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Fable 5 just made my CUDA kernels 5x faster
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Just installed DeepSeek4 flash 0731 on a dual RTX6000 Blackwell system. Had to jump through a couple hoops, but ended up with 170 token gen/a. Hooked up open code and go.
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Here we go, Opus 5 is live
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Thank you @claudeai for supporting open source bioinformatics <3
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GPT 5.6 is not following my C++ guidelines at all. Disappointed
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Hey @thsottiaux, this is too close together ;)
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Give me an open model that matches Opus 4.8 coding capabilities and I'll just keep using that
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No matter what I try and how much I'm trimming references, Fable 5 refuses to work on any of my bioinformatics, signal analysis, and data processing problems. Sucks.
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GPT-5.6 would accelerate genomics at an unprecedented pace. @sama we could use your help, thx
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Hey @bcherny, it would be great if we could /compact and /clear remote sessions from mobile.
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Opus down, back to manual coding
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