📄 Our paper, developed from my internal medicine residency thesis at Akdeniz University (
@Akdenizun), is now published in
@Cancers_MDPI .
🧠 We studied 166 patients with recurrent glioblastoma, IDH-wildtype. At first recurrence, 114 received a bevacizumab-containing strategy and 52 a non-bevacizumab strategy.
🔎 After propensity-score overlap weighting with multiple imputation, bevacizumab-containing treatment was not associated with improved post-recurrence overall survival (HR 1.40, 95% CI 0.93 to 2.10) or prPFS (HR 0.81, 95% CI 0.55 to 1.18).
⚠️ Yet documented second progression was much less frequent with bevacizumab (cause-specific HR 0.29, 95% CI 0.16 to 0.53), while death before documented progression was more frequent (HR 1.65, 95% CI 0.93 to 2.93).
At 24 months, documented second progression was 20.2% vs 55.3%, while death before documented progression was 65.5% vs 34.7%.
⚖️ This is important because prPFS combines events moving in opposite directions. In the antiangiogenic setting, less radiographic progression does not necessarily translate into better disease control or longer survival.
🙏 Grateful to Prof. Dr. Sema Sezgin Göksu, Dr. Galip Can Uyar (
@uyargalip), and my mentor Assoc. Prof. Dr. Osman Sütcüoğlu (
@osutcuoglu) for their support throughout this project.
🔗
mdpi.com/2072-6694/18/16/266…
@EANOassociation
#Glioblastoma #NeuroOncology #MedicalOncology #Bevacizumab #CancerResearch #EANO