PantheonOS Now Tackles Gene Panel Design Gene panel selection represents a critical bottleneck in spatial and single-cell genomics, where suboptimal choices compromise cell-type resolution and experimental validity. Pantheon automates this end-to-end via multi-agent workflow orchestration. A leader agent orchestrates the full pipeline, delegating to specialized analyzers that dynamically route tools and benchmark strategies in real time — enabling long-horizon, autonomous discovery. What can Pantheon do? 🧬 Multi-strategy gene selection — orchestrating parallel selection strategies to synthesize a single optimized panel. 📊 Clustering-aware optimization and biological grounding — directly maximizing ARI/NMI metrics while grounding decisions in domain knowledge, for panels that are both statistically and biologically meaningful. 📄 Self-documenting, reproducible runs — generating live notebooks, agent traces, and automated PDF reports with zero manual intervention. Unless you want to interact with it! Benchmarked on pan-cancer immuno-oncology with @Vizgen, PantheonOS achieves superior overlap with expert-curated panels while outperforming classical baselines on clustering metrics. Built on PantheonOS — the first evolvable, multi-agent operating system for biological discovery. Genomics is the beginning; the architecture goes beyond, and PantheonOS is fine-tunable for domain-specific scientific research. 📄 Preprint: biorxiv.org/content/10.64898… 🌐 Website: pantheonos.stanford.edu Thank you to Erwin and @Nanguage for this incredible opportunity, and to @JiangHe_PhD , Lorenz Rongioni and the entire Vizgen @vizgen_inc team for the amazing collaboration. More to come soon!