The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.
Boston, MA
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New TYP lab publication is out today! A phenomenal review by @Heuerwego, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!
Human cellular models of the brain to study #lipid homeostasis in #AlzheimersDisease and related dementias
Sarah E. Heuer @Heuerwego, Fasih M. Ahsan, Tracy L. Young-Pearse @YoungPearseLab @BrighamWomens #ipscs
link.springer.com/article/10…
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Congratulations to TYP lab postdoc @Heuerwego on being awarded a F32 NRSA Postdoctoral Fellowship through the NIA, titled "Identifying the cellular consequences of ABCA7 genetic risk in Alzheimer's disease." Looking forward to more amazing findings from Dr. Heuer's work!
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Congratulations to the Young-Pearse lab's newest doctor @GizemTerzioglu_ on her successful PhD defense!!! We are so proud of her!!
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We are excited to welcome Nalini Oliver to the lab! We are thrilled that she chose to join our lab for her thesis through Harvard's BBS program and look forward to working with her!
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We are happy to welcome Julia Choi to the lab as our newest undergrad! We are also excited to have Arnab Misra and Cecilia Riordan-Bourges continuing their studies in our lab this summer as well!
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TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @FogoGarrett and PhD student Olivia Pembridge all gave great talks! @rushalzheimers #ROSMAP
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Shoutout graduate student Olivia Pembridge who gave a fantastic talk on her work studying the role of VGF in excitatory neurons at the Annual ROSMAP conference and won the Martha Ondrey Jr. Investigator Award 🏆 @rushalzheimers #rosmap
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We had the opportunity to present our work using iPSC models to study vascular dysfunction in AD at the Vascular Contributions to Cognitive Impairment (VCID) workshop at WashU! Great conversations and new connections. Grateful to be part of such an impactful meeting! #VCID2026
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Shout out to our fabulous postdoc @Heuerwego who gave a great talk on her work investigating genetic risk factors influencing dysfunction in microglia in AD at the ACT Research Symposium hosted by @kpwashington ! #ACT2026
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Exciting science from our own Dr. Benoit at the Harvard Bipolar Symposium! Her poster on a population-scale single-cell atlas of peripheral immune cells in bipolar disorder highlights the growing importance of immune mechanisms in psychiatric disease. 🔬
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Young-Pearse Lab retweeted
Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @YoungPearseLab that I've been working on over the past few years!
alzforum.org/news/conference…
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We had inspiring discussions, established new collaborations, and the had the opportunity to share our work at the BD² Funded Investigators Meeting in Fort Lauderdale. We are grateful to be a part of a community working to help individuals with bipolar disorder thrive.
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Excited to share our latest review!!🧠
“Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin”
Check it out here: authors.elsevier.com/sd/arti…
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We are excited to share our latest publication “POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" in Brain, which we discuss in the recent Brain Podcast episode check it out here:
open.spotify.com/episode/1sf…
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Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!
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Thank you to Paul Tesar and Raeka Aiyar for including us in the inaugural Translational Glial Sciences Conference in the Institute for Glial Sciences at Case Western Reserve University School of Medicine. It was a great event!
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We're excited to share our new pre-print, where @GizemTerzioglu_ et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia.
biorxiv.org/content/10.1101/…
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Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!
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We are excited to share our latest publication “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" in Acta Neuropathologica this week! Congratulations Zack Augur!!
link.springer.com/epdf/10.10…
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