Today in
@Nature, we report a new approach to studying human brain development and modeling disease in vivo.
Human neural
#assembloids and
#organoids have opened new ways to study development in vitro, but they also have important limitations. Transplantation can provide a more physiological environment, yet human cortical cells then develop within a rodent brain that matures much faster, constraining their growth and integration.
To address some of these limitations and obtain more advanced functional readouts relevant to disease biology, we generated
#apallial mice, in which ~98% of the cortex and hippocampus fail to form, creating space for transplanted human cortical organoids to grow and integrate extensively.
We call these
#xenocortical mice (XCX).
Nearly 7 years in the making. Congratulations to an extraordinary team and wonderful collaborators!
Link to the article below 👇