Two flights in 8 hours cancelled by Air Canada for mechanical reasons. No more confidence in @AirCanada and yet I don’t have a fucking choice if I want to go to Montreal or Toronto bc @united is too lazy to go there. Missing time with my mother that I can’t get back

Don't miss out on this year's Weinstein Conference on Cardiovascular Development & Regeneration, in New York, May 6-8! weinstein-conference.com/ Apply for a travel award ($500-1,000) by April 10th by filling out the following form: forms.gle/kpvL3oR3sQFc5NMR9

Excited to share MaxToki, a temporal AI model that predicts the impact of perturbations on cell states over time along dynamic trajectories. We applied MaxToki to predict how cells age across the human lifespan & discovered new cardiac pro-aging drivers that we validated in vivo.

Hi @united UA1844 1/31/2026 does not have screen power and the rear restrooms (it’s a 757) are non-functional (only one now for the entire economy set). We’ve paid a lot including those of us in business. I’m returning from a family tragedy and was hoping for better.

“This is a court of law, not a court of morals,” he said” Oh what a terribly missed opportunity here!

How does heart failure rewire gene regulation? 🔍 Excited to share our single-cell, multimodal epigenomic resource on human heart failure🫀: doi.org/10.1101/2025.05.08.2….

Grateful & humbled to make the 2025 #TIME100HEALTH list with such inspiring global health leaders. This honor reflects my team, who are unrelenting in their efforts to advance new treatments for pancreatic cancer!

for #heart month, a nice piece on what we at @GladstoneInst are doing to understand heart disease better. Featuring @m_alexanian @TheodorisLab and Katie Pollard. for heart month, a nice little piece on what we do at Gladstone for the heart gladstone.org/news/matters-h…

The latest from @GladstoneInst of Cardiovascular Research and @ucsf: Isha Jain's lab, with an outstanding discovery of a small molecule that mimics hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, RA in Isha's lab, is first author! cell.com/cell/fulltext/S0092…

reupping this request to support my daughter's fundraising efforts for the @americanheart It's a worthy cause, and she is learning a lot from it. Thank you for considering. heart.org/site/TR?px=2899227…

Hey there! Please consider supporting my daughter Nika as she raises funds for the American Heart Association as a 2025 Teen of Impact nominee. More than ever we need support for cardiovascular research, and this is a noble way to help. Thank you! heart.org/site/TR?px=2899227…

Ten years. Together we built a warm, tight-knit, international community, shared new computational and experimental technologies around the the world, posted >400 preprints, and catalyzed understanding of the mechanisms and functions of chromatin in development and disease.

Hey friends. Come over to the blue skies. It’s warm and friendly and we’re all there.

Check out this wonderful Perspective piece in @ScienceMagazine by Christina Theodoris @UCSF @GladstoneInst: science.org/doi/10.1126/scie…

OMG attorney general wtf

Yes join us

Happy to share our new work describing DESynR genes! The evolution of new human protein-coding genes relies on repurposing protein domains from ancestral genes, rather than de novo sequence creation. New genes evolved from old parts, and while we have methods that enable high-throughput generation and screening of base-pair level sequence evolution (mutagenesis, directed evolution, CRISPR, etc), we lack similar scalable technologies for domain-level evolution. We developed a high-throughput combinatorial molecular assembly method to generate thousands of barcoded novel genes from the domain building blocks of natural genes, termed DESynR (Domain Engineered via Synthesis and Recombination) genes.

A little noise making @wbderry @TheLovelyLab @chrmosimann

Same

The 3rd edition of this comprehensive review on the genetics and biology of #PancreaticCancer is now published in @GenesDev genesdev.cshlp.org/content/e… Updated information with several useful illustrations and citations. Thanks @RonDePinho @HaoqiangY @rkalluriMDPhD Alec Kimmelman, Nabeel Bardeesy. Enjoy!