SCIENTIFIC JOURNAL group by @SpringerNature Cell Death & Differentiation, Death & Disease, Cell Death Discovery bsky.app/profile/cddpress.bs…
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“Hepatitis B virus protein X promotes survival and loss of hepatocyte identity in a differentiated human liver organoid system”
This physiologically relevant organoid model clarifies longstanding questions about the pathogenesis of #HBV-associated #HCC ⤵️
nature.com/articles/s41418-0…
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🌏International Cell Death Seminar Series - Edition #2🌏
Details:
📅Date: Wednesday 14th October
🕰️Time: 4:30pm AEDT / 8:30am CEST
💻Webinar link: lnkd.in/erx2zZAN
See the flyer below for more information ⤵️
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“The expanding MDM2 universe”
Fresh off the press: an editorial by Prof. Engeland about the recently uncovered connection between MDM2 and #InnateImmunity ⤵️
nature.com/articles/s41418-0…
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"MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA"
nature.com/articles/s41418-0…
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“Immunoregulatory role of quercetin in lung cancer”
Quercetin exerts potent #Antioxidant, #AntiProliferative, and #Immunomodulatory effects ⤵️
nature.com/articles/s41420-0…
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“Cuproptosis in iron overload hepatocytes”
Copper as a potent and previously underappreciated modifier of iron-induced cellular injury ⤵️
nature.com/articles/s41419-0…
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“PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression”
PGC1 represses HIF signaling via ERR-driven EGLN1 transcriptional induction, expanding its #TumorSuppressive role in #PCa ⤵️
nature.com/articles/s41418-0…
@fagomaider
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“MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease”
An #iPSC-derived hepatocyte model to investigate MIC13-associated mitochondrial #hepatopathy ⤵️
nature.com/articles/s41419-0…
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Blocking cancer lipid synthesis can trigger a distinct #Senescence program ⤵️
Fatty acid synthesis therapy-induced senescence (FASTIS) exhibits a molecular signature distinct from the TIS programs triggered by DNA-damaging agents or CDK4/6 inhibition including a poorly inflammatory but highly immunomodulatory #SASP
nature.com/articles/s41419-0…
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“SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an m5C modification”
Potential genetic markers and therapeutic targets for #NOA ⤵️
nature.com/articles/s41418-0…
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"ATP synthase subunits e and g are essential for Ca2+ homeostasis and development in Drosophila melanogaster independent of oxidative phosphorylation"
Researchers at @dsb_unipd uncovered a novel role for ATP Synthase in #Ca2+ homeostasis in #Drosophila ⤵️
nature.com/articles/s41418-0…
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“Recognition and management of acute relapse of multiple sclerosis, neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease”
Check out this recent review in CDD ⤵️
nature.com/articles/s41418-0…
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“SUMOylated Reptin maintains low intracellular ROS levels by activating mitophagy to drive gemcitabine resistance in gallbladder cancer”
A self-reinforcing mitophagy/ROS/SENP3/Reptin loop emerges as a potential core resistance mechanism in #GBC ⤵️
nature.com/articles/s41419-0…
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“The skin-specific long non-coding RNA TEDAR orchestrates late epidermal differentiation via an ERK-KLF4 cytoplasmic regulatory axis”
A novel lncRNA-mediated regulatory axis essential for proper skin barrier formation ⤵️
nature.com/articles/s41419-0…
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“Canonical lymphocyte chemokine receptors CXCR3 and CXCR5 modulate neuronal autophagy”
This work from Rubinsztein’s lab @TheCIMR describes unforseen roles of chemokines as #Autophagy stimulators ⤵️
nature.com/articles/s41418-0…
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🎗️🎗️ September is a busy month for #CancerAwareness
Explore our comprehensive collection of research in the threads below ⤵️
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🎗️Urological Cancer
Cell Death & Disease
nature.com/subjects/urologic…
Cell Death Discovery
nature.com/subjects/urologic…
#UrologicalCancer #CancerResearch #Urology
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🎗️Gynaecological Cancer
Cell Death & Disease
nature.com/subjects/gynaecol…
Cell Death Discovery
nature.com/subjects/gynaecol…
#GynaecologicalCancerAwarenessMonth #GynaecologicalCancer
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“The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism via mitochondrial transporter activity and lipid alterations”
Read how IGF2BP2 affects the overall metabolism of #ColorectalCancer cells ⤵️
nature.com/articles/s41420-0…
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