Cell Host & Microbe@cellhostmicrobe

The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.

 Cambridge, MA
cell.com/cell-host-microbe
Joined November 2014
2,573 Photos and videos
September issue is now live! Take a journey through our latest issue with insights into MTb susceptibility & containment, probiotics improving endometrial receptivity, oral commensal nanovaccines stimulating anti-tumor immunity & more…… cell.com/cell-host-microbe/c…
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Weekend read! Female urogenital microbiome Sarah Lebeer & Co In urogenital tract, dominant lactobacilli shape vaginal immunity & community stability. Review examines molecular strategies & rational design of next-generation microbiome-based therapies cell.com/cell-host-microbe/a…

The female urogenital microbiome: Ecological insights, therapeutic strategies, and molecular...

In the urogenital tract, dominant lactobacilli shape vaginal immunity and community stability. In this review, Dillen and Dricot et al. integrate clinical and mechanistic evidence on their molecular...

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Cell Host & Microbe retweeted
Duke Microbiome Center@DukeMicrobiome
Sep 24
Could a sugar molecule produced by a gut bacterium offer a viable alternative to GLP-1s? A new paper in @cellhostmicrobe sheds light on a previously unknown link between the gut microbiome and metabolism.
Duke University School of Medicine@DukeMedSchool
Sep 24
Neeraj Surana, MD, PhD, and colleagues identified a previously unknown connection between the gut microbiome and metabolism. Their findings suggest a naturally occurring gut bacterium may help regulate energy expenditure and visceral fat. medschool.duke.edu/news/swee…
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One year ago--Veillonella promotes C. diff Oral commensal Veillonella promotes C. difficile germination by disrupting bile acid recycling. Veillonella LPS activates signaling to suppress BA transporter, preventing bile acid reabsorption cell.com/cell-host-microbe/f…

Veillonella intestinal colonization promotes C. difficile infection in Crohn’s disease

Yang et al. identify the oral commensal Veillonella as a key driver of Clostridioides difficile infection in Crohn’s disease. Veillonella promotes pathogen germination by disrupting bile acid...

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Commensal-derived sugar protects against obesity Clostridium immunis & its bioactive phosphocholine-modified exopolysaccharide (EPS) reduces visceral adiposity & weight gain. By decreasing IL-22 levels, EPS increases metabolic activity in visceral fat cell.com/cell-host-microbe/f…

A commensal-derived sugar protects against obesity by regulating immunometabolism

Tan et al. identify a human commensal bacterium, Clostridium immunis—and its bioactive phosphocholine-modified exopolysaccharide (EPS)—that reduces visceral adiposity and weight gain in mice. By...

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Cell Host & Microbe retweeted
Cell Press@CellPressNews
Sep 23
A commensal-derived sugar protects against obesity by regulating immunometabolism. Learn more in Cell Host & Microbe: cell.com/cell-host-microbe/f… Neeraj K. Surana & colleagues @cellhostmicrobe
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Weekend revisit! E. faecalis lactic acid suppresses macrophages E. faecalis-derived lactic acid suppresses macrophage NF-κB activation via MCT-1 & GPR81. This lactic-acid-driven immunosuppression promotes bacterial persistence & polymicrobial infection cell.com/cell-host-microbe/f…

Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent...

da Silva et al. show that Enterococcus faecalis-derived lactic acid suppresses macrophage NF-κB activation via MCT-1 and GPR81 signaling. This lactic-acid-driven immunosuppression promotes bacterial...

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Diet drives Bacteroides remodeling to promote IgA binding Pectin drives B. uniformis remodeling to enrich surface glycosphingolipid HexCer. Neutrophils sense signal to promote IgA production, which helps bacterium colonize gut & protects against colitis cell.com/cell-host-microbe/a…

Dietary pectin remodels commensal bacterial surfaces to promote IgA-mediated protection from...

Tang et al. reveal that dietary pectin drives Bacteroides uniformis surface remodeling to enrich the surface glycosphingolipid HexCer. Neutrophils sense this signal via CLEC4E to promote IgA produc...

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Timely revisit! Abs power MMR efficacy against measles Measles-specific mAbs isolated from MMR vaccinee potently & broadly neutralize, target conserved sites & protect animals post exposure, opening means to prevent/treat measles as outbreaks re-emerge cell.com/cell-host-microbe/f…

Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins

Acciani, Zyla et al. identify a panel of human monoclonal antibodies against measles virus surface proteins. These antibodies neutralize with picomolar potency, target conserved sites, broadly...

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Microbial IAM alleviates PCOS C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model cell.com/cell-host-microbe/a…
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Rice circadian clock coordinates rhizosphere to optimize N acquisition Clock component Nhd1 drives rhythmic root exudation to regulate microbial Nitrogen turnover. SynC microbes matching rice Nhd1 rhythm enhance grain yield & N use efficacy cell.com/cell-host-microbe/a…
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Bacteria promote CaOx stones C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization cell.com/cell-host-microbe/a…

Hippuric acid metabolism by Corynebacterium glucuronolyticum-like bacteria promotes calcium oxalate...

Qi et al. identify Corynebacterium glucuronolyticum-like (C. glucuronolyticum-like) bacteria enriched in the urine of calcium oxalate (CaOx) stone patients and show that they promote CaOx crystalli...

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Oral commensal nanovaccines for tumor control Bacteria-based oral biohybrid vaccine induces mucosal immunity & drives a mucosa-periphery-tumor immune cascade. Combined w/PD-1 blockade, enhances immune cell trafficking, remodels distal TME & tumor control cell.com/cell-host-microbe/a…

Engineering oral commensal nanovaccines to activate mucosal-systemic immune cascades against tumor

Dong et al. develop a bacteria-based oral biohybrid vaccine that induces mucosal immunity and drives a mucosa-periphery-tumor immune cascade. Combined with PD-1 blockade, this strategy enhances...

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Pulling the strings: Endobacteria manipulate fungal mycotoxin production Preview of work taking a comprehensive look at an endofungal bacterium, identifying a mechanism to change plant disease outcomes through antagonism of beneficial soil microbes. cell.com/cell-host-microbe/a…

Pulling the strings: Endobacteria manipulate fungal mycotoxin production

In an overlooked but common phenomenon, bacteria colonize fungi and change how the eukaryotic microbe inhabits niches. In this issue, Wei et al. present a comprehensive look at an endofungal bacter...

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Endosymbionts boost fungi by disrupting rhizobiome Bacterial endosymbionts stimulate Fusarium wilt to produce cyclic hexadepsipeptide beauvericin, which inhibits disease-suppressive rhizobacteria, thereby weakening microbiome-mediated suppression cell.com/cell-host-microbe/f…
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Plant cell-type-specific immune activation Plant immunity is organized across leaf tissues through specialized cell-type programs. While a shared core program is broadly activated, individual cell types deploy distinct defenses that restrict pathogens cell.com/cell-host-microbe/f…

Cell-type-specific activation of broadly perceived effector-triggered immunity restricts pathogen...

Chhillar et al. reveal that plant immunity is organized across leaf tissues through specialized cell-type programs. While a shared core immune program is broadly activated, individual cell types...

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Holding the granuloma together: Fibroblasts contain mycobacterial infection Preview of work identifying LTA4H-dependent fibroblasts at the granuloma periphery that regulate eicosanoid signaling, thereby limiting mycobacterial dissemination cell.com/cell-host-microbe/a…

Holding the granuloma together: Fibroblasts contain mycobacterial infection

Genetic variation in leukotriene A4 hydrolase (LTA4H) influences tuberculosis severity, but underlying mechanisms remain unclear. In this issue, Hughes et al. identify LTA4H-dependent fibroblasts at...

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Eicosanoids-Fibroblasts contain MTb TB susceptibility gene lta4h contributes to recruitment & differentiation of fibroblasts that populate periphery of mycobacterial granulomas. These eicosanoid-regulated fibroblasts help contain infection in granuloma cell.com/cell-host-microbe/f…

Host eicosanoid signals define a granuloma fibroblast population that coordinates mycobacterial...

Hughes et al. find that the TB susceptibility gene lta4h contributes to the recruitment and differentiation of a discrete set of fibroblasts that populate the periphery of mycobacterial granulomas in...

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Gabija restricts phage circularization & DNA replication Gabija prevents phage genome circularization & replication w/out impacting bacterial host. Exposed DNA ends & phage end-binding proteins license DNA targeting while RecBCD protects host from Gabija cell.com/cell-host-microbe/a…

Gabija restricts phage circularization and DNA replication

Gabija acts early during phage infection, preventing phage genome circularization and replication. Phage DNA end-binding proteins prevent RecBCD loading onto linear DNA, and the absence of RecBCD...

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Bacteroides PA alleviates metabolic syndrome Pantothenic acid (PA)⬇️in adults w/MetS. B. fragilis PA sustains KLF4-associated epithelial differentiation, strengthening gut barrier & alleviating MetS. Plant polysaccharide ⬆️Bacteroides to boost protection cell.com/cell-host-microbe/a…

Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome

Luo et al. show microbial pantothenic acid (PA) is reduced in metabolic syndrome. Bacteroides fragilis-derived PA, produced through panC, sustains KLF4-associated epithelial differentiation through...

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Interferon family feud determines immunity to mycobacteria Preview of work providing evidence for antagonism of type I interferons and interferon-γ as an important determinant of susceptibility against Mtb infection. cell.com/cell-host-microbe/a…

Interferon family feud determines immunity to mycobacteria

The immune response to Mycobacterium tuberculosis (Mtb) infection leverages the interferon system. In this issue of Cell Host & Microbe, Fattinger and colleagues provide compelling evidence for a...

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