A personalized mRNA cancer vaccine passed Phase 3, genuinely great news for melanoma patients!
What happens here? They sequence your tumor, find up to 34 mutations unique to it, and build a custom vaccine that trains your immune system to hunt those exact cells.
In a phase 2 trial earlier this year the vaccine with immunotherapy has shown ~49% lower risk of recurrence or death vs immunotherapy alone, which is the current standard of care. We are waiting now for the details of the phase 3.
After that that concept is now expanding to lung, kidney, bladder cancer and hopefully to many more to come.
Huge win for science!